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Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study

Published online by Cambridge University Press:  09 March 2007

Tiina H. Rissanen ,
Sari Voutilainen ,
Kristiina Nyyssönen ,
Timo A. Lakka ,
Juhani Sivenius ,
Riitta Salonen ,
George A. Kaplan  and
Jukka T. Salonen
Tiina H. Rissanen
Affiliation:
Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland
Sari Voutilainen
Affiliation:
Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland
Kristiina Nyyssönen
Affiliation:
Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland
Timo A. Lakka
Affiliation:
Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland
Juhani Sivenius
Affiliation:
Department of Neuroscience and Neurology, University of Kuopio and Brain Research and Rehabilitation Center Neuron, Kuopio, Finland
Riitta Salonen
Affiliation:
Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland
George A. Kaplan
Affiliation:
School of Public Health, University of Michigan, Ann Arbor, Michigan, 48109-2029 USA
Jukka T. Salonen*
Affiliation:
Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland Inner Savo Health Centre, Suonenjoki, Finland
*
*Corresponding author: Professor Jukka T. Salonen, fax +358 17 162 936, email [email protected]
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Abstract

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A number of epidemiological studies have shown an association between β-carotene and the risk of cardiovascular diseases, whereas only a few studies are available concerning the association of lycopene with the risk of coronary events, and no studies have been undertaken concerning lycopene and stroke. Thus, we tested the hypothesis that low serum levels of lycopene are associated with increased risk of acute coronary events and stroke in middle-aged men previously free of CHD and stroke. The subjects were 725 men aged 46–64 years examined in 1991–3 in the Kuopio Ischaemic Heart Disease Risk Factor Study. Forty-one men had either a fatal or a non-fatal acute coronary event or a stroke by December 1997. In a Cox' proportional hazard's model adjusting for examination years, age, systolic blood pressure and three nutritional factors (serum folate, β-carotene and plasma vitamin C), men in the lowest quarter of serum lycopene levels (≤0·07 μmol/l) had a 3·3-fold (95 % CI 1.7, 6.4, P < 0·001) risk of acute coronary events or stroke compared with the others. Our study suggests that a low serum level of lycopene is associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke.

Keywords

LycopeneCoronary eventStroke
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 6 , May 2001 , pp. 749 - 754
Copyright
Copyright © The Nutrition Society 2001

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