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Long-term supplementation with selenate and selenomethionine: urinary excretion by New Zealand women

Published online by Cambridge University Press:  24 July 2007

Marion F. Robinson ,
Christine D. Thomson ,
Christopher P. Jenkinson ,
Gu Luzhen  and
Philip D Whanger
Marion F. Robinson
Affiliation:
Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand
Christine D. Thomson
Affiliation:
Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand
Christopher P. Jenkinson
Affiliation:
Mental Retardation Research Center, Center for Health Science, 760 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90024-1759., USA
Gu Luzhen
Affiliation:
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, 29 Nan Wei Road, Beijing, People's Republic of China
Philip D Whanger
Affiliation:
4Department of Agricultural Chemistry, Oregon State University, Corvallis, Oregon 97331 -6502, USA
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Abstract

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Thirty-six New Zealand women aged between 18 and 23 years received daily for 32 weeks, 200 µg Se as Se-enriched yeast (selenomethionine, SeMet), or brewer's yeast mixed with selenate, or no added Se (placebo) in a double-blind trial. Mean daily Se excretion increased with both supplements; the selenate group excreted more than the SeMet group, 123 v. 66 µg/d respectively at week 2, equivalent to 57 v. 27 % of the dose. Thereafter Se output increased for the SeMet group reaching a plateau at about 100 µg/d at week 16, when plasma Se had also plateaued at 190 ng/ml. The selenate group had reached an earlier plateau of 110 ng Se/ml at week 7. There was a close relationship between 24 h urine and plasma Se for the SeMet group but not for the selenate group. Renal plasma clearances showed two distinctly different responses; the clearance of 0·4 ml/min reached by the SeMet group at week 2 plateaued as plasma Se increased almost 2-fold; whereas for the selenate group the clearance varied between 0·8 and 1·1 ml/min whilst plasma Se remained almost constant at 110 ng/ml. Previous studies, also of 200 µgSe/d as Se-rich bread, in New Zealand (NZ) and elsewhere showed similar responses to Se-yeast; the selenite response was intermediate between selenate and Se-yeast (SeMet). The full significance of these studies awaits identification of Se components in plasma, glomerular filtrate and urine; meanwhile renal clearances serve as a pointer to changes in the distribution of Se-containing fractions in the plasma. Trimethylselenonium was detected in basal urines, and was a minor component in urines of supplemented NZ subjects at about 1 % of the total Se.

Keywords

SeleniumUrinary excretionRenal plasma clearanceWomen
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 4 , April 1997 , pp. 551 - 563
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Alfthan, G., Aro, A., Arvilommi, H. & Huttunen, J. K. (1991). Selenium metabolism and platelet glutathione peroxidase activity in healthy Finnish men: effects of selenium yeast, selenite, and selenate. American Journal of Clinical Nutrition 53, 120–125.CrossRefGoogle ScholarPubMed
Alaejos, M. S. & Romero, C. D. (1993). Urinary selenium concentrations. Clinical Chemistry 39, 2040–2052.Google Scholar
Beilstein, M. A. & Whanger, P. D. (1986). Deposition of dietary organic and inorganic selenium in rat erythrocyte proteins. Journal of Nutrition 116, 1701–1710.Google Scholar
Bingham, S. A. & Cummings, J. H. (1985). The use of creatinine output as a check on the completeness of 24-hour urine collections. Human Nutrition: Clinical Nutrition 39C, 343–353.Google Scholar
Brown, M. W. & Watkinson, J. H. (1977). An automated fluorimetric method for the determination of nanogram quantities of selenium. Analytica Chimica Acta 89, 29–35.Google Scholar
Burk, R. F. (1974). In vivo 75Se binding to human plasma proteins after administration of 75SeO⅔-. Biochimica et Biophysica Acta 372, 255–265.CrossRefGoogle Scholar
Burk, R. F. (1976). Selenium in man. In Trace Elements in Human Health and Disease, vol. 2, pp. 105–133. London: Academic Press.Google Scholar
Burk, R. F. (1986). Selenium and cancer: meaning of serum selenium levels. Journal of Nutrition 116, 1584–1586.CrossRefGoogle ScholarPubMed
Butler, J. A., Thomson, C. D., Whanger, P. D. & Robinson, M. F. (1991). Selenium distribution in blood fractions of New Zealand women taking organic or inorganic selenium. American Journal of Clinical Nutrition 53, 748–754.Google Scholar
Clarke, J. T. (1961). Colorimetric determination and distribution of urinary creatinine and creatine. Clinical Chemistry 7, 271–283.CrossRefGoogle Scholar
Janghorbani, M., Martin, R. F., Kasper, L. J., Sun, X. F. & Young, V. R. (1990). The selenite-exchangeable metabolic pool in humans: a new concept for the assessment of selenium status. American Journal of Clinical Nutrition 51, 670–677.Google Scholar
Koushanpour, E. & Kriz, W. (1986). Renal Physiology, 2nd ed. New York: Springer-Verlag.Google Scholar
Kraus, R. J., Foster, S. J. & Ganther, H. E. (1985). Analysis of trimethylselenonium in urine by high performance liquid chromatography. Analytical Biochemistry 147, 432–436.Google Scholar
Levander, O. A., Alfthan, G., Arvilommi, H., Gref, G. C., Huttunen, J. K., Kataja, M. K., Koivistoinen, P. & Pikkarainen, J. (1983). Bioavailability of selenium to Finnish men as assessed by platelet glutathione peroxidase activity and other blood parameters. American Journal of Clinical Nutrition 37, 887–897.CrossRefGoogle ScholarPubMed
Levander, O. A. & Burk, R. F. (1990). Selenium. In Present Knowledge of Nutrition, 6th ed., pp. 268–273 [Brown, M. L. editor]. Washington DC: ILSI, Nutrition Foundation.Google Scholar
Luo, X., Wei, H., Yang, C., Xing, J., Qiao, C., Feng, Y., Liu, J., Liu, Z., Wu, Q., Liu, Y., Stoecker, B. J., Spallholz, J. E. & Yang, S. P. (1985). Selenium intake and metabolic balance of 10 men from a low selenium area of China. American Journal of Clinical Nutrition 42, 31–37.Google Scholar
Meltzer, H. M., Norheim, G., Bibow, K., Myhre, K. & Holm, H. (1990). The form of selenium determines the response to supplementation in a selenium replete population. European Journal of Clinical Nutrition 44, 497–508.Google Scholar
Meltzer, H. M., Norheim, G., Loken, E. B. & Holm, H. (1992). Supplementation with wheat selenium induces a dose-dependent response in serum and urine of a Se-replete population. British Journal of Nutrition 67, 287–294.Google Scholar
Mills, G. & Hocken, A. G. (1986). Microalbuminuria in a diabetic population. New Zealand Medical Journal 99, 17–19.Google Scholar
Nahapetian, A. T., Young, V. R. & Janghorbani, M. (1984). Measurement of trimethylselenonium ion in human urine. Analytical Biochemistry 140, 56–62.Google Scholar
Oster, O. & Prellwitz, W. (1990). The renal excretion of selenium. Biological Trace Element Research 24, 119–146.CrossRefGoogle ScholarPubMed
Robberecht, H. J. & Deelstra, H. A. (1984). Selenium in human urine: determination, speciation and concentration levels. Talanta 31, 497–508.CrossRefGoogle ScholarPubMed
Robinson, J. R., Robinson, M. F., Levander, O. A. & Thomson, C. D. (1985). Urinary excretion of selenium by New Zealand and North American human subjects on differing intakes. American Journal of Clinical Nutrition 41, 1023–1031.Google Scholar
Robinson, M. F. (1988). The New Zealand selenium experience. American Journal of Clinical Nutrition 48, 521–534.Google Scholar
Robinson, M. F., Jenkinson, C. P., Luzhen, G., Thomson, C. D. & Whanger, P. D. (1989). Urinary excretion of selenium (Se) and trimethylselenonium (TMSe) by New Zealand women during long-term supplementation with selenate or selenomethionine (SeMet). In Selenium in Biology and Medicine, pp. 250–253 [Wendel, A. editor]. Heidelberg: Springer-Verlag.Google Scholar
Sandholm, M. (1973). The initial fate of a trace amount of intravenously administered selenite. Acta Pharmacologica et Toxicologica 33, 1–5.CrossRefGoogle ScholarPubMed
Sun, X. A., Ting, B. T. G. & Janghorbani, M. (1987). Excretion of trimethylselenonium ion in human urine. Analytical Biochemistry 167, 304–311.Google Scholar
Sunde, R. A. (1990). Molecular biology of selenoproteins. Annual Review of Nutrition 10, 451–474.Google Scholar
Thomson, C. D., Burton, C. E. & Robinson, M. F. (1978). On supplementing the selenium intake of New Zealanders: 1. Short experiments with large doses of selenite or selenomethionine. British Journal of Nutrition 39, 579–587.Google Scholar
Thomson, C. D., Ong, L. K. & Robinson, M. F. (1985). Effects of supplementation with high-selenium wheat bread on selenium, glutathione peroxidase and related enzymes on blood components of New Zealand residents. American Journal of Clinical Nutrition 41, 1015–1022.CrossRefGoogle ScholarPubMed
Thomson, C. D. & Robinson, M. F. (1986). Urinary and faecal excretions and absorption of a large supplement of selenium: superiority of selenate over selenite. American Journal of Clinical Nutrition 44, 659–663.CrossRefGoogle ScholarPubMed
Thomson, C. D., Robinson, M. F., Butler, J. A. & Whanger, P. D. (1993). Long-term supplementation with selenate and selenomethionine: selenium and glutathione peroxidasse (EC 1.11.1.9) in blood components of New Zealand women. British Journal of Nutrition 69, 577–588.Google Scholar
Thomson, C. D., Robinson, M. F., Campbell, D. R. & Rea, H. M. (1982). Effect of a prolonged supplementation with daily supplements of selenomethionine and sodium selenite on glutathione peroxidase activity on blood of New Zealand residents. American Journal of Clinical Nutrition 36, 24–31.Google Scholar
Thomson, C. D., Steven, S. M., Van Rij, A. M., Wade, C. R. & Robinson, M. F. (1988). Selenium and vitamin E supplementation: activities of glutathione peroxidase in human tissue. American Journal of Clinical Nutrition 48, 316–323.Google Scholar
Van Der Torre, H. W., Van Dokkum, W., Schaafsma, G., Wedel, M. & Ockhuizen, T. (1991). Effect of various levels of selenium in wheat and meat on blood Se status indices and on Se balance in Dutch men. British Journal of Nutrition 65, 69–80.Google Scholar
Varo, P., Alfthan, G., Ekholm, P., Aro, A. & Koivistoinen, P. (1988). Selenium intake and serum selenium in Finland: effects of soil fertilization with selenium. American Journal of Clinical Nutrition 48, 324–329.Google Scholar
Webster, J. & Garrow, J. S. (1985). Creatinine excretion over 24 hours as a measure of body composition or of completeness of urine collection. Human Nutrition: Clinical Nutrition 39C, 101–106.Google Scholar