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Long-term sucrose-drinking causes increased body weight and glucose intolerance in normal male rats

Published online by Cambridge University Press:  08 March 2007

Takahiro Kawasaki ,
Akiko Kashiwabara ,
Tadashi Sakai ,
Kanji Igarashi ,
Nobuyuki Ogata ,
Hiroyuki Watanabe ,
Kaoru Ichiyanagi  and
Toshikazu Yamanouchi
Takahiro Kawasaki*
Affiliation:
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan
Akiko Kashiwabara
Affiliation:
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan
Tadashi Sakai
Affiliation:
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan
Kanji Igarashi
Affiliation:
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan
Nobuyuki Ogata
Affiliation:
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan
Hiroyuki Watanabe
Affiliation:
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan
Kaoru Ichiyanagi
Affiliation:
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan
Toshikazu Yamanouchi
Affiliation:
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan
*
*Corresponding author: Dr Takahiro Kawasaki, fax +81 3 3964 1353, email [email protected]
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Abstract

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The current epidemic of diabetes likely reflects marked changes in environmental factors, although genetic susceptibility plays a powerful role in the occurrence of diabetes in certain populations. We investigated whether long-term sucrose-drinking causes hyperglycaemia in male Wistar-Imamichi littermates (n 32), which are not genetically susceptible to diabetes or obesity. Each litter was divided equivalently into two groups, the sucrose group and the control group. The sucrose group received 300 g/l sucrose water and the control group received regular water until 42 weeks of age. Rats were weighed every 1 or 2 weeks. Oral glucose tolerance tests were performed at 28 and 36 weeks of age. Plasma glucose and insulin concentrations were measured. Body weights were significantly greater in the sucrose group than in the control group in 18-week-old rats (P<0·05), and the difference between the two groups reached 163 g by the end of the study (P<0·01). The 120 min post-load plasma glucose concentration in the sucrose group was 11·4 (sd 2·8) mmol/l in 28-week-old rats and 12·7 (sd 2·2) mmol/l in 36-week-old rats, while that of the control group remained approximately 7·3–7·7 mmol/l. In the sucrose group, the plasma insulin peak occurred 30 min post-load at 28 weeks of age; but the peak disappeared and hyperinsulinaemia was prolonged at 36 weeks of age. In conclusion, long-term sucrose-drinking causes increased body weight and glucose intolerance in normal male rats.

Keywords

Dietary sucroseExperimental diabetes mellitusType 2 diabetes mellitusEnvironmentalLitter sizeWistar rats
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 5 , May 2005 , pp. 613 - 618
Copyright
Copyright © The Nutrition Society 2005

References

Blakely, SR, Hallfrisch, J, Reiser, S & Prather, ES (1981) Long-term effects of moderate fructose feeding on glucose tolerance parameters in rats. J Nutr 111, 307–314.CrossRefGoogle ScholarPubMed
Chicco, A, D'Alessandro, ME, Karabatas, L, Pastorale, C, Basabe, JC & Lombardo, YB (2003) Muscle lipid metabolism and insulin secretion are altered in insulin-resistant rats fed a high sucrose diet. J Nutr 133, 127–133.CrossRefGoogle ScholarPubMed
Edelstein, SL, Knowler, WC & Brain, RP (1997) Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes 46, 701–710.CrossRefGoogle ScholarPubMed
Gibney, MJ (1990) Dietary guidelines, a critical appraisal. J Hum Nutr Diet 3, 245–254.CrossRefGoogle Scholar
James, J, Thomas, P, Cavan, D & Kerr, D (2004) Preventing childhood obesity by reducing consumption of carbonated drinks: cluster randomised controlled trial. Br Med J 328, 1237.CrossRefGoogle ScholarPubMed
Janket, SJ, Manson, JE, Sesso, H, Buring, JE & Liu, S (2003) A prospective study of sugar intake and risk of type 2 diabetes in women. Diabetes Care 26, 1008–1015.CrossRefGoogle ScholarPubMed
Koyama, M, Wada, R, Sakuraba, H, Mizukami, H & Yagihashi, S (1988) Accelerated loss of islet β cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus. Am J Pathol 153, 537–545.CrossRefGoogle Scholar
Kuczmarski, RJ, Flegal, KM, Campbell, SM & Johnson, CL (1994) Increasing prevalence of overweight among US adults: the National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA 272, 205–211.CrossRefGoogle ScholarPubMed
Levi, B & Werman, MJ (1998) Long-term fructose consumption accelerates glycation and several age-related variables in male rats. J Nutr 128, 1442–1449.CrossRefGoogle ScholarPubMed
Ludwig, DS, Peterson, KE & Gortmaker, SL (2001) Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective observational analysis. Lancet 357, 505–508.CrossRefGoogle ScholarPubMed
Marshall, JA, Bessesen, DH & Hamman, RF (1997) High saturated fat and low starch and fiber are associated with hyperinsulinaemia in a non-diabetic population: the San Luis Valley Diabetes Study. Diabetologia 40, 430–438.CrossRefGoogle Scholar
Meyer, KA, Kushi, LH, Jacobs, Jr, DR, Slavin, J, Sellers, Folsom, TAAR (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 71, 921–930.CrossRefGoogle ScholarPubMed
Mokdad, AH, Bowman, BA, Ford, ES, Vinicor, F, Marks, JS & Koplan, JP (2001) The continuing epidemics of obesity and diabetes in the United States. JAMA 12, 1195–1200.CrossRefGoogle Scholar
Nelson, M & Bringham, S (1991) Assessment of food consumption and nutrient intake. In Design Concepts in Nutritional Epidemiology, pp. 153–191 [Margetts, BM, Nelson, M, editors]. New York: Oxford University Press.Google Scholar
Raben, A, Vasilaras, TH, Møller, AC & Astrup, A (2002) Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10wk of supplementation in overweight subjects. Am J Clin Nutr 76, 721–729.CrossRefGoogle Scholar
Reiser, S, Bohn, E, Hallfrisch, JG, Michaelis, OE, IV, Keeny M, Prather, ES (1981) Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose. Am J Clin Nutr 34, 2348–2358.CrossRefGoogle ScholarPubMed
Stark, AH, Timar, B & Madar, Z (2000) Adaptation of Sprague Dawley rats to long-term feeding of high fat or high fructose diets. Eur J Nutr 39, 229–234.CrossRefGoogle ScholarPubMed
Storlin, LH, Kraegen, EW, Jenskins, AB & Chisholm, DJ (1988) Effects of sucrose vs starch diets on in vivo insulin action, thermogenesis, and obesity in rats. Am J Clin Nutr 47, 420–427.CrossRefGoogle Scholar
Tsunehara, CH, Leonetti, DL & Fujimoto, WY (1990) Diet of second-generation Japanese-American men with and without non-insulin-dependent diabetes. Am J Clin Nutr 52, 731–738.CrossRefGoogle ScholarPubMed
Tulp, OL, Hansen, CT, McKee, K, Michaelis, OE IV (1991) Effects of diet and phenotype on adipose cellularity and 5'-deiodinase activity of liver and brown adipose tissue of diabetic SHR/N-cp rats. Comp Biochem Physiol 99, 457–462.CrossRefGoogle Scholar