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Level of nutrition and age at weaning: effects on humoral immunity in young calves

Published online by Cambridge University Press:  09 March 2007

J. M. Pollock ,
T. G. Rowan ,
J. B. Dixon  and
S. D. Carter
J. M. Pollock
Affiliation:
Departments of Animal Husbandry, university of liverpool, Liverpool L69 3BX Veterinary Pathology, university of liverpool, Liverpool L69 3BX
T. G. Rowan
Affiliation:
Departments of Animal Husbandry, university of liverpool, Liverpool L69 3BX
J. B. Dixon
Affiliation:
Veterinary Pathology, university of liverpool, Liverpool L69 3BX
S. D. Carter
Affiliation:
Veterinary Pathology, university of liverpool, Liverpool L69 3BX Veterinary Clinical Sciences, University of Liverpool, Liverpool L69 3BX
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Abstract

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Thirty-two calves were studied to determine the effects of level of nutrition (400 and 1000 g (air-dry matter) milk substitute per d) and age at weaning (5, 9 and 13 weeks) on humoral immune responses measured in serum and bronchoalveolar washings (BAW). All calves were immunized with Keyhole limpet haemocyanin (KLH) at 3 weeks of age, and with horse erythrocytes (HRBC) 1 d after weaning. Feeding the higher level of nutrition compared with the lower level decreased anti-HRBC titres and serum IgG2 and IgA responses to KLH (P < 0·05). Weaning at 5 compared with 9 weeks of age decreased serum anti-HRBC responses (P < 0·05), but weaning age had no effect on anti-KLH responses (P > 0·5). Feeding the higher level of nutrition increased total protein (P < 005) and IgG2 concentrations (P < 0·01) in BAW. The results showed that variation in husbandry conditions that is within conventional limits affects humoral immune responses in young, artificially-reared calves.

Keywords

Level of nutritionWeaningImmune functionCalves
Type
Diet and immunology
Information
British Journal of Nutrition , Volume 71 , Issue 2 , February 1994 , pp. 239 - 248
Copyright
Copyright © The Nutrition Society 1994

References

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