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Lesions produced by copper deficiency in neonate and older rats

Published online by Cambridge University Press:  24 July 2007

G. A. Hall  and
J. McC. Howell
G. A. Hall
Affiliation:
Department of Veterinary Pathology, University of Liverpool
J. McC. Howell
Affiliation:
Department of Veterinary Pathology, University of Liverpool
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Abstract

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1. Three groups of rats of different mean weights were given a diet of milk treated with hydrogen sulphide and supplemented with copper-free minerals and vitamins. Also divided into three groups of similar weights were rats given the same diet supplemented with 500 μg Cu/week and stock rats which were given a commercial diet.

2. In a second experiment eight adult female rats were given the Cu-deficient diet for 2 weeks before mating and during pregnancy, and in a third experiment were mated and immediately after mating were given the Cu-deficient diet or the Cu-supplemented diet.

3. Cu deficiency reduced the growth rate of younger rats but had a much less marked effect on the weight of more mature rats. Achromotrichia appeared at 5 weeks; diarrhoea, with the faeces frequently containing undigested blood, and subcutaneous oedema were terminal changes. Deaths occurred in the youngest group of rats after 9 weeks and later in heavier, older rats.

4. Histological changes were seen in livers, spleens, testes and epididymes but not in blood vessels or bones.

5. Pups were not born to mothers given the deficient diet before mating, and the pups from mothers given the deficient diet only during pregnancy were born dead or showed congenital abnormalities.

6. Foetal and liver Cu concentrations for the various groups of animals are given.

7. Maintenance of the foetus appears to be the biological process most susceptible to Cu deficiency in the rat.

Type
Research Article
Information
British Journal of Nutrition , Volume 29 , Issue 1 , January 1973 , pp. 95 - 104
Copyright
Copyright © The Nutrition Society 1973

References

REFERENCES

Carlton, W. W. & Kelly, W. A. (1969). J. Nutr. 97, 12.CrossRefGoogle Scholar
Cook, M. J. & Moore, D. F. (1967). Br. J. exp. Path. 48, 150.Google Scholar
Dreosti, I. E. & Quicke, G. V. (1966). S. Afr. J. agric. Sci. 9, 365.Google Scholar
Dutt, B. & Mills, C. F. (1960). J. comp. Path. 70, 120.CrossRefGoogle Scholar
Elvehjem, C. A. & Kemmerer, A. R. (1931). J. biol. Chem. 93, 189.CrossRefGoogle Scholar
Gallagher, C. H. (1955). Pathological and enzymological disturbances in copper and allied deficiencies. PhD Thesis, University of London.Google Scholar
Gallagher, C. H. (1957). Aust. vet. J. 33, 311.CrossRefGoogle Scholar
Hall, G. A. & Howell, J. McC. (1969). Br. J. Nutr. 23, 47.CrossRefGoogle Scholar
Hart, E. B., Steenbock, H., Waddell, J. & Elvehjem, C. A. (1928). J. biol. Chem. 77, 797.CrossRefGoogle Scholar
Hill, C. H., Starcher, B. & Kim, C. (1968). Fedn Proc. Fedn Am. Socs exp. Biol. 26, 129.Google Scholar
Howell, J. McC. & Hall, G. A. (1969). Br. J. Nutr. 23, 47.CrossRefGoogle Scholar
Keil, H. I. & Nelson, V. E. (1931). J. biol. Chem. 93, 49.CrossRefGoogle Scholar
McCosker, P. J. (1967). Br. J. Nutr. 21, 231.CrossRefGoogle Scholar
O'Dell, B. L., (1968). Fedn Proc. Fedn Am. Socs exp. Biol. 27, 199.Google Scholar
O'Dell, B.L., Hardwick, B. C. & Reynolds, G. (1961). J. Nutr. 73, 151.CrossRefGoogle Scholar
Rucker, R. B., Parker, H. E. & Rogler, J. C. (1969). J. Nutr. 98, 57.CrossRefGoogle Scholar
Staples, R. E. & Schnell, V. L. (1964). Stain Technol. 39, 61.Google Scholar
Underwood, E. J. (1971). Tract elements in Human and Animal Nutrition 3rd ed. New York and London: Academic Press Inc.Google Scholar
Waisman, J., Cancilla, P. A. & Coulson, W. F. (1969). Lab. Invest. 21, 548.Google Scholar
Warren, P. J. (1962). Br. J. Nutr. 16, 167.CrossRefGoogle Scholar