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Lead and iron absorption from rat small intestine: the effect of dietary Fe deficiency

Published online by Cambridge University Press:  09 March 2007

I. K. Robertson  and
M. Worwood
I. K. Robertson
Affiliation:
Department of Haematology, Welsh National School of Medicine, Cardiff CF4 4XN
M. Worwood
Affiliation:
Department of Haematology, Welsh National School of Medicine, Cardiff CF4 4XN
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Abstract

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1. When lead is administered in drinking-water iron-deficient rats retain more Pb than Fe-replete rats (Six & Goyer, 1972; Klauder & Petering, 1975). In the present study the relationship between the absorption of Pb and Fe was investigated.

2. Adult male rats were transferred to a milk-based diet fed with or without supplementary Fe (180 mg Fe/kg as ferrous sulphate). After 7–9 d the absorption of duodenally-administered 203Pb and 59Fe was measured as uptake of radioactivity from the gastrointestinal tract after 90 min. 59Fe absorption was increased in rats given the unsupplemented diet for 7 d and was further increased in rats kept on the diet for up to 7 weeks. 203Pb absorption was not consistently increased by either short- or long-term Fe deprivation.

3. Much of the 203Pb in homogenates of the upper small intestine was bound to soluble protein of which up to 85% was dialysable. In contrast little 59Fe was dialysable. Only a small proportion of the soluble musosal Pb was associated with ferritin during gel-filtration chromatography although 203Pb precipitated together with carrier rat-liver ferritin with an antibody to rat-liver ferritin.

4. There appeared to be no direct relationship between the transfer of Fe and Pb across the small intestine of the adult rat.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 40 , Issue 2 , September 1978 , pp. 253 - 260
Copyright
Copyright © The Nutrition Society 1978

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