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Lactose intolerance and bone mass in postmenopausal Italian women

Published online by Cambridge University Press:  09 March 2007

Gino R. Corazza ,
Giuseppe Benati ,
Antonio Di Sario ,
Carlo Tarozzi ,
Alessandra Strocchi ,
Mario Passeri  and
Giovanni Gasbarrini
Gino R. Corazza
Affiliation:
Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy
Giuseppe Benati
Affiliation:
Department of Medical Pathology, University of Bologna, Bologna, Italy
Antonio Di Sario
Affiliation:
Department of Medical Pathology, University of Bologna, Bologna, Italy
Carlo Tarozzi
Affiliation:
Division of Nuclear Medicine, Ospedale Maggiore, Bologna, Italy
Alessandra Strocchi
Affiliation:
Department of Medical Pathology, University of Bologna, Bologna, Italy
Mario Passeri
Affiliation:
Department of Medicine, University of Parma, Parma, Italy
Giovanni Gasbarrini
Affiliation:
Department of Medical Pathology, University of Bologna, Bologna, Italy
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Abstract

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Previous studies on the role of lactose malabsorption in the pathogenesis of postmenopausal osteoporosis have yielded conflicting results and further information is needed. To date, all studies have been carried out on populations with a low prevalence of lactose malabsorption and the lactose intestinal absorptive capacity was tested using a non-physiological dose of lactose. In fifty-eight Italian postmenopausal women (mean age 57 (SD 7) years), bone mineral density (BMD) at lumbar spine, H2 breath response after ingestion of 20 g lactose, intensity of symptoms of intolerance after a lactose load and daily Ca intake were evaluated. No differences were found between women with or without a positive H2, breath test with regard to BMD (−1·2 (SD 0·9) ν −0·9 (SD 0·8)) and Ca intake (509 (SD 266) ν 511 (SD 313) mg/d). On the contrary, both BMD and Ca intake were significantly lower in women with lactose malabsorption and symptoms of intolerance (−1·5 (SD 0·7) and 378 (SD 220) mg/d) than in those with malabsorption without symptoms (−0·9 (SD 0·9) and 624 (SD 254) mg/d). Moreover, in lactose malabsorbers Ca intake was correlated inversely with symptom score (rs −0·31, P<0·05) and positively with BMD (rs 0·42, P<0·005). Our results show that in Italian postmenopausal women Ca intake and BMD are not influenced directly by lactose malabsorption; the appearance of symptoms of intolerance seems to influence BMD unfavourably through a reduced Ca intake.

Keywords

CalciumH2 breath testLactoseOsteoporosisPostmenopausal women
Type
Lactose intolerance and osteoporosis
Information
British Journal of Nutrition , Volume 73 , Issue 3 , March 1995 , pp. 479 - 487
Copyright
Copyright © The Nutrition Society 1995

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