Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-25T15:24:32.275Z Has data issue: false hasContentIssue false
  • English
  • Français

Jejunal absorption of an amino acid mixture simulating casein and an enzymic hydrolysate of casein prepared for oral administration to normal adults

Published online by Cambridge University Press:  25 March 2008

D. B. A. Silk ,
M. L. Clark ,
T. C. Marrs ,
Jill M. Addison ,
D. Burston ,
D. M. Matthews  and
K. Mary Clegg
D. B. A. Silk
Affiliation:
Department of Medicine and Gastroenterology, St Bartholomew's Hospital, London EC1A 7BE
M. L. Clark
Affiliation:
Department of Medicine and Gastroenterology, St Bartholomew's Hospital, London EC1A 7BE
T. C. Marrs
Affiliation:
Department of Experimental Chemical Pathology, Westminster Medical School, London
Jill M. Addison
Affiliation:
Department of Experimental Chemical Pathology, Westminster Medical School, London
D. Burston
Affiliation:
Department of Experimental Chemical Pathology, Westminster Medical School, London
D. M. Matthews
Affiliation:
Department of Experimental Chemical Pathology, Westminster Medical School, London
K. Mary Clegg
Affiliation:
Department of Food Science and Nutrition, University of Strathclyde, Glasgow
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. An intestinal perfusion technique was used in six normal human subjects to study absorption of sixteen individual amino acids from an amino acid mixture simulating casein and from an enzymic hydrolysate of casein, prepared for oral administration to these subjects, which consisted of a mixture of oligopeptides and free amino acids.

2. Total absorption of α-amino nitrogen was greater from the casein hydrolysate than from the amino acid mixture, and the considerable variation in percentage absorption of individual amino acids from the amino acid mixture was much reduced when the enzymic hydrolysate solution was perfused, as a number of amino acids which were poorly absorbed from the amino acid mixture were absorbed to a greater extent from the casein hydrolysate.

3. These findings indicate that after extensive intestinal resections or in malabsorption there might be significant nutritional advantages in the administration of protein hydrolysates rather than amino acid mixtures.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 33 , Issue 1 , January 1975 , pp. 95 - 100
Copyright
Copyright © The Nutrition Society 1975

References

Adibi, S. A. & Mercer, D. W. (1973). J. clin. Invest. 52, 1586.CrossRefGoogle Scholar
Cannon, P. R., Steffee, C. H., Frazier, L. J., Rowley, D. A. & Stepto, R. C. (1947). Fedn Proc. Fedn Am. Socs exp. Biol. 6, 390.Google Scholar
Chen, M. L., Rogers, Q. R. & Harper, A. E. (1962). J. Nutr. 76, 235.CrossRefGoogle Scholar
Clegg, K. M. & McMillan, A. D. (1974). J. Fd Technol. (In the Press.)Google Scholar
Cook, G. C. (1973 a). Br. J. Nutr. 29, 377.CrossRefGoogle Scholar
Cook, G. C. (1973 b). Br. J. Nutr. 30, 13.CrossRefGoogle Scholar
Crampton, R. F., Gangolli, S. D., Simson, P. & Matthews, D. M. (1971). Clin. Sci. 41, 409.CrossRefGoogle Scholar
Gitler, C. (1964). In Mammalian Protein Metabolism Vol. 1 p. 66 [Munro, H. N., editor] New York and London: Academic Press.Google Scholar
Holdsworth, C. D. & Dawson, A. M. (1964). Clin. Sci. 27, 371.Google Scholar
Ling, E. R., Kon, S. K. & Porter, J. W. G. (1961). In Milk: The Mammary Gland and its Secretion Vol. 2, p. 195 [Kon, S. K. and Cowie, A. T., editors] New York and London: Academic Press.CrossRefGoogle Scholar
Matthews, D. M. (1971). J. clin. Path. 24, Suppl. 5, 29.CrossRefGoogle Scholar
Matthews, D. M. (1972). Ciba Fdn Symp. p. 71.Google Scholar
Mercier, J. C., Grosslande, F. & Dumas, B. R. (1972). Milchwissenschaft 27, 402.Google Scholar
Milne, M. D. (1972). Ciba Fdn Symp. p. 93.Google Scholar
Nixon, S. E. & Mawer, G. E. (1970). Br. J. Nutr. 24, 241.CrossRefGoogle Scholar
Rees, M. W. (1946). Biochem. J. 40, 632.CrossRefGoogle Scholar
Silk, D. B. A. (1974). Gut 15, 494.CrossRefGoogle Scholar
Silk, D. B. A., Marrs, T. C., Addison, J. M., Burston, D., Clark, M. L. & Matthews, D. M. (1973). Clin. Sci. mol. Med. 45, 715.Google Scholar
Silk, D. B. A., Perrett, D. & Clark, M. L. (1973). Clin. Sci. mol. Med. 45, 291.Google Scholar
Silk, D. B. A., Perrett, D., Webb, J. P. W. & Clark, M. L. (1974). Clin. Sci. mol. Med. 46, 393.Google Scholar
Snedecor, G. W. (1937). Statistical Methods. Ames, Iowa: Iowa State Medical College Press.Google Scholar
Wingate, D. L., Sandberg, R. J. & Phillips, S. F. (1972). Gut 13, 812.CrossRefGoogle Scholar