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Is an antioxidant-rich or a pro-inflammatory diet during pregnancy associated with allergic and respiratory multimorbidity in children from the ELFE birth cohort?

Published online by Cambridge University Press:  04 November 2024

Rosalie Delvert Open the ORCID record for Rosalie Delvert [Opens in a new window] ,
Courtney Dow ,
Marie-Aline Charles ,
Karine Adel-Patient ,
Amandine Divaret-Chauveau ,
Marie-Noëlle Dufourg ,
Bénédicte Leynaert ,
Chantal Raherison ,
Raphaëlle Varraso  and
Blandine de Lauzon-Guillain Open the ORCID record for Blandine de Lauzon-Guillain [Opens in a new window]
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Rosalie Delvert*
Affiliation:
Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, Villejuif, France
Courtney Dow
Affiliation:
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France
Marie-Aline Charles
Affiliation:
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France Unité mixte Inserm-Ined-EFS ELFE, Ined, Aubervilliers, France
Karine Adel-Patient
Affiliation:
Université Paris-Saclay, CEA, INRAE, DMTS, SPI/Laboratoire d’Immuno-Allergie Alimentaire, Gif-sur-Yvette, France
Amandine Divaret-Chauveau
Affiliation:
Unité d’allergologie pédiatrique, Hôpital d’Enfants, CHRU de Nancy, UR3450 DevAH, Université de Lorraine, Vandoeuvre-lès-Nancy, France
Marie-Noëlle Dufourg
Affiliation:
Unité mixte Inserm-Ined-EFS ELFE, Ined, Aubervilliers, France
Bénédicte Leynaert
Affiliation:
Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, Villejuif, France
Chantal Raherison
Affiliation:
Bordeaux University, Inserm, Bordeaux Population Health Research Center, Team EPICENE, UMR 1219, Bordeaux, France Service de pneumologie, CHU de Guadeloupe, Pointe-à-Pitre, France
Raphaëlle Varraso
Affiliation:
Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, Villejuif, France
Blandine de Lauzon-Guillain
Affiliation:
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France
Annabelle Bédard
Affiliation:
Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, Villejuif, France
*
Corresponding author: Rosalie Delvert; Email: [email protected]
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Abstract

The antioxidant capacity and the inflammatory potential of diet during pregnancy may represent a prevention opportunity for allergic and respiratory diseases. We aimed to investigate the associations between the antioxidant and the inflammatory potential of maternal diet in the last 3 months of pregnancy with allergic and respiratory diseases in children. Analyses were performed on 9679 mother–child pairs from the ELFE birth cohort. The dietary total antioxidant capacity (DTAC), without coffee, was estimated with the Trolox equivalent antioxidant capacity (TEAC), the total radical trapping antioxidant parameter (TRAP) and the ferric reducing-antioxidant power (FRAP). The inflammatory potential of the maternal diet was assessed by the energy-adjusted dietary inflammatory index (E-DII). Allergic and respiratory diseases in children up to 5·5 years were considered jointly through five allergic and respiratory multimorbidity clusters (‘asymptomatic’ - reference, ‘early wheeze without asthma’, ‘asthma only’, ‘allergies without asthma’ and ‘multi-allergic’). Multinomial logistic regressions were performed and adjusted for main confounders. A diet with a higher antioxidant potential was associated with a lower risk of belonging to the ‘early wheeze without asthma’ cluster (aOR (95 % CI) = 0·95 (0·90, 0·99) per sd of TEAC score). A higher E-DII was associated with a higher risk of belonging to the ‘asthma only’ cluster (aOR (95 % CI) = 1·09 (1·00, 1·19) per sd). No association was found with the ‘allergies without asthma’ or ‘multi-allergic’ clusters. An antioxidant-rich diet during pregnancy was associated with better respiratory health, while a pro-inflammatory diet was associated with poorer respiratory health in children up to 5·5 years, though the associations were weak.

Keywords

Maternal dietAntioxidantInflammationPregnancyAllergyAsthmaPaediatricsEpidemiology
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 10 , 28 November 2024 , pp. 1356 - 1364
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

The authors contributed equally to this work

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