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Inulin attenuates atherosclerosis in apolipoprotein E-deficient mice

Published online by Cambridge University Press:  08 March 2007

Marie-Hélène Rault-Nania ,
Elyett Gueux ,
Céline Demougeot ,
Christian Demigné ,
Edmond Rock  and
Andrzej Mazur
Marie-Hélène Rault-Nania
Affiliation:
Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR1019, INRA, Theix, Centre de Recherche en Nutrition Humaine d'Auvergne, 63122 Saint-Genès-Champanelle, France
Elyett Gueux
Affiliation:
Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR1019, INRA, Theix, Centre de Recherche en Nutrition Humaine d'Auvergne, 63122 Saint-Genès-Champanelle, France
Céline Demougeot
Affiliation:
Laboratoire de Physiologie et Pharmacologie – Nutrition Préventive Expérimentale, Faculté de Médecine et de Pharmacie, Besançon, France
Christian Demigné
Affiliation:
Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR1019, INRA, Theix, Centre de Recherche en Nutrition Humaine d'Auvergne, 63122 Saint-Genès-Champanelle, France
Edmond Rock
Affiliation:
Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR1019, INRA, Theix, Centre de Recherche en Nutrition Humaine d'Auvergne, 63122 Saint-Genès-Champanelle, France
Andrzej Mazur*
Affiliation:
Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR1019, INRA, Theix, Centre de Recherche en Nutrition Humaine d'Auvergne, 63122 Saint-Genès-Champanelle, France
*
*Corresponding author: Dr Andrzej Mazur, fax +33 4 73 62 4638, email [email protected]
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Abstract

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Effects of different inulin-type fructan fractions were studied on atherosclerotic plaque formation in male apo E-deficient mice. Thirty-two mice were randomly divided into four groups and received either a semi-purified sucrose-based diet (control group), or diets in which sucrose was replaced in part by various inulin-type fructans (10 g/100 g): long-chain inulin, oligofructose, or an oligofructose-enriched inulin for 16 weeks. The presence of atherosclerotic plaques was assessed by histomorphometry in the aortic sinus. The apo E-deficient mice fed long-chain inulin or an oligofructose-enriched inulin had about 35 % and 25 % less atherosclerotic lesion area compared with the control group, respectively. Feeding long-chain inulin significantly reduced plasma cholesterol concentrations (P<0·001), and the three inulin-type fructans reduced triacylglycerol (TAG) concentrations compared with the control group (P<0·001). Both the long-chain inulin and an oligofructose-enriched inulin significantly lowered hepatic cholesterol concentrations compared with the control diet (P<0·05). Hepatic TAG concentrations were significantly lower in all three groups fed the fructan-supplemented diets v. the control group (P<0·0001). The results of the present study suggest that inhibition of atherosclerotic plaque formation is more potent in the presence of long-chain inulin, either alone or in combination with oligofructose (an oligofructose-enriched inulin), and that this probably is related to changes in lipid metabolism.

Keywords

InulinOligofructoseApolipoprotein E-deficient miceAtherosclerosis
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 5 , November 2006 , pp. 840 - 844
Copyright
Copyright © The Nutrition Society 2006

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