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Intradialytic parenteral nutrition: comparison of olive oil versus soybean oilbasedlipid emulsions

Published online by Cambridge University Press:  08 March 2007

Noël J. M. Cano ,
Yannick Saingra ,
Anne-Marie Dupuy ,
Anne-Marie Lorec-Penet ,
Henri Portugal ,
Denis Lairon ,
Jean-Paul Cristol ,
Adrien Come ,
Alexia Le Brun  and
Philippe Atlan
...Show all authors
Noël J. M. Cano*
Affiliation:
Service d'Hépatogastroent´rologie et Nutrition, Clinique Résidence du Parc, Rue Gaston Berger, 13362, Marseille cedex 10, France
Yannick Saingra
Affiliation:
Service d'Hépatogastroent´rologie et Nutrition, Clinique Résidence du Parc, Rue Gaston Berger, 13362, Marseille cedex 10, France
Anne-Marie Dupuy
Affiliation:
Laboratorie de Biochimie, Hopital hapeyronie, 371 Avenue Doyen Gaston Gvaud, 34295 Montpellier, France
Anne-Marie Lorec-Penet
Affiliation:
Laboratoire central, CHU Sainte-Marguerite, Boulerard Sainte-Marguerite, 13009 Marseilles, France
Henri Portugal
Affiliation:
Laboratoire central, CHU Sainte-Marguerite, Boulerard Sainte-Marguerite, 13009 Marseilles, France
Denis Lairon
Affiliation:
UMR 476-INSERM/1260-INRA, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
Jean-Paul Cristol
Affiliation:
Laboratorie de Biochimie, Hopital hapeyronie, 371 Avenue Doyen Gaston Gvaud, 34295 Montpellier, France
Adrien Come
Affiliation:
Baxter SAS, 6 Avenue Louis Pasteur, BP 56, 7811 Maurepas, Cedex France
Alexia Le Brun
Affiliation:
Baxter SAS, 6 Avenue Louis Pasteur, BP 56, 7811 Maurepas, Cedex France
Philippe Atlan
Affiliation:
Baxter SAS, 6 Avenue Louis Pasteur, BP 56, 7811 Maurepas, Cedex France
Xavier M. Leverve
Affiliation:
INSERM-E0221, Bioénergétique Fondamentale et Appliqueé, Université- BP 53XF Joseph Fourier, 38041 Grenoble, Cedex France
*
*Corresponding author:fax +33 4 91 83 88 38, email [email protected]
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Abstract

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Lipid, oxidative and inflammatory parameters are frequently altered in dialysis patients and may be worsened by intravenous lipid emulsions (ILE). We assessed the efficacy and tolerance of olive as compared with standard soybean oil-based ILE during intradialytic parenteral nutrition (IDPN). IDPN mixtures containing amino acids, glucose, and either olive oil (OO group, n 17) or soybean oil-based ILE (SO group, n 18) were administered in a 5-week randomized, double-blind study. On days 0 and 35, patients' nutritional status was assessed by BMI, normalized protein catabolic rate, predialytic creatinine, serum albumin and transthyretin; lipid metabolism by plasma LDL- and HDL-cholesterol, triacylglycerols, phospholipids, apo A-I, A-II, B, C-II, C-III, E and lipoprotein (a); oxidative status by α-tocopherol, retinol, selenium, glutathione peroxidase, malondialdehyde and advanced oxidized protein products; inflammatory status by serum C-reactive protein, orosomucoid, IL-2 and IL-6. No serious adverse event was observed. Significant changes were observed from day 0 to day 35 (P<0·05): nutritional criteria improved (albumin in OO; albumin, transthyretin and creatinine in SO); LDL-cholesterol, apo B, C-II, C-III and apo A-I/A-II ratio increased in both groups. HDL-cholesterol decreased in OO; apo E increased and lipoprotein (a) decreased in SO; α-tocopherol/cholesterol ratio increased in OO; malondialdehyde decreased in both groups; IL-2 increased in both groups. The between-group comparison only showed the following differences: α-tocopherol/cholesterol increased in OO; lipoprotein (a) decreased in SO. From these data, it was concluded that OO- and SO-based IDPNs similarly improved nutritional status and influenced plasma lipid, oxidative, inflammatory and immune parameters.

Keywords

HaemodialysisIntradialytic parenteral nutritionFat emulsionsOlive oil
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 1 , January 2006 , pp. 152 - 159
Copyright
Copyright © The Nutrition Society 2006

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