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Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects

Published online by Cambridge University Press:  08 March 2007

Jacques Delarue ,
Chang-Hong Li ,
Richard Cohen ,
Charlotte Corporeau  and
Brigitte Simon
Jacques Delarue*
Affiliation:
Equipe d'Accueil 948 ‘Oxylipides’, Laboratoire Régional de Nutrition Humaine, Faculté de Médecine de Brest & CHU, F-29 200 Brest, France
Chang-Hong Li
Affiliation:
Jeune Equipe 313 ‘Lipides et Croissance’, Faculté de Médecine, F-37 000 ToursFrance
Richard Cohen
Affiliation:
Fédération de Biochimiebiologie spécialiséeimmunoanalyseHôpital Edouard HerriotF-69 000 LyonFrance
Charlotte Corporeau
Affiliation:
Equipe d'Accueil 948 ‘Oxylipides’, Laboratoire Régional de Nutrition Humaine, Faculté de Médecine de Brest & CHU, F-29 200 Brest, France
Brigitte Simon
Affiliation:
Equipe d'Accueil 948 ‘Oxylipides’Faculté de Médecine de BrestF-29 200 BrestFrance
*
*corresponding author: Professor Jacques Delarue, fax +33 2 98 34 78 82, email [email protected]
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Abstract

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Compared with saturated fat, n-3 long-chain PUFA-rich fish oil improves insulin sensitivity in rats. We studied whether n-3 long-chain PUFA could prevent insulin resistance induced by dexamethasone (a glucocorticoid) in healthy human volunteers. A group of eight subjects was studied twice after a 2d dexamethasone treatment, before and after a 3-week supplementation with fish oil (providing daily doses of 1·1g 20:5n-3 and 0·7g 22:6n-3). The subjects were studied during the basal state and over the 6h following an oral glucose load (1g/kg). Plasma glucose fluxes were traced with [6,6-2H2]glucose and [13C]glucose (naturally 13C-enriched corn glucose). Substrate oxidation was obtained from indirect calorimetry. Following fish oil supplementation, plasma glucose fluxes and substrate oxidation were maintained despite a 17% reduction (P<0·05) in the area under the curve of plasma insulin response, suggesting an insulin-sensitizing effect.

Keywords

Eicosapentaenoic acidDocosahexaenoic acidPolyunsaturated fatty acidsStable isotopesInsulin resistance
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 2 , February 2006 , pp. 267 - 272
Copyright
Copyright © The Nutrition Society 2006

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