Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-29T01:54:21.207Z Has data issue: false hasContentIssue false
  • English
  • Français

Interaction of dietary carbohydrate and fat in the regulation of hepatic and extrahepatic lipogenesis in the rat

Published online by Cambridge University Press:  09 March 2007

Gene R. Herzberg  and
Maria Rogerson
Gene R. Herzberg
Affiliation:
Biochemistry Department, Memorial University of Newfoundland, St John's, Newfoundland AIB 3X9, Canada
Maria Rogerson
Affiliation:
Biochemistry Department, Memorial University of Newfoundland, St John's, Newfoundland AIB 3X9, Canada
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. In order to examine the interaction of dietary fat and carbohydrate in the regulation of lipid metabolism, we have studied hepatic and extrahepatic lipogenesis, and adipose tissue lipoprotein lipase (EC 3.1.1.34) in rats fed on one of the following diets: a fructose-based diet containing 0 (F0) or 150 g maize oil (F15)/kg, or a glucose based diet containing 0 (G0) or 150 g maize oil (G15)/kg.

2. The rats were meal-fed on the diets for 2 weeks after which the activities of a number of hepatic ‘lipogenic’ enzymes were measured and the activity of epididymal-fat-pad lipoprotein lipase. The activities of the lipogenic enzymes were: F0 > G0 > G15 > F15. Lipoprotein lipase activity was F0 = G0 = F15 = G15. The percentage of total body fatty acid synthesis which occurred in the liver was F0 > G0 > F15 > G15.

3. We conclude that fructose-induced hypertriglyceridaemia is primarily a result of the increased hepatic synthesis rather than decreased adipose-tissue lipoprotein lipase activity.

Type
Other Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 59 , Issue 2 , March 1988 , pp. 233 - 241
Copyright
Copyright © The Nutrition Society 1988

References

Adelman, R. C., Spolter, P. D. & Weinhouse, S. (1966). Journal of Biological Chemistry 241, 5467–5472.CrossRefGoogle Scholar
Baker, N., Learn, D. B. & Bruckdorfer, K. R. (1978). Journal of Lipid Research 19, 879–893.CrossRefGoogle Scholar
Bar-On, H. & Stein, Y. (1968). Journal of Nutrition 94, 95–105.CrossRefGoogle Scholar
Bernt, E. & Bergmeyer, H. U. (1974). In Methods of Enzymatic Analysis, vol. 2, pp. 1304–1307. [Bergmeyer, H. U., editor]. New York: Academic Press.Google Scholar
Beynen, A. C., Haagsman, M.P., Van Golde, L. M. G. & Geelen, M. J. H. (1981). Biochimica et Biophysica Acta 665, 1–7.CrossRefGoogle Scholar
Bird, M., Williams, M. A. & Baker, N. (1984). Journal of Nutrition 114, 1978–1985.CrossRefGoogle Scholar
Bruckdorfer, K. R., Khan, I. H. & Yudkin, J. (1972). Biochemical Journal 129, 439–446.CrossRefGoogle Scholar
Chevalier, M. M., Wilsey, J. H. & Leveille, G. A. (1972). Journal of Nutrition 102, 337–342.CrossRefGoogle Scholar
Cohen, A. M. & Teitelbaum, A. (1968). Life Science 7, 23–29.Google Scholar
Cryer, A. (1981). International Journal of Biochemistry 13, 525–541.CrossRefGoogle Scholar
Cryer, A., Riley, S. E., Williams, E. R. & Robinson, D. S. (1974). Biochemical Journal 140, 561–563.CrossRefGoogle Scholar
Curry, D. L., Curry, K. P. & Gomez, M. (1972). Endocrinology 9, 1493–1498.Google Scholar
Fitch, W. W. & Chaikoff, I. L. (1960). Journal of Biological Chemistry 235, 544–557.Google Scholar
Gibson, D. M. & Hubbard, D. D. (1960). Biochemical and Biophysical Research Communications 3, 531–535.CrossRefGoogle Scholar
Goa, J. (1953). Scandanavian Journal of Clinical Laboratory Investigation 5, 218–222.CrossRefGoogle Scholar
Herzberg, G. R. (1983). Advances in Nutritional Research 5, 221–253.CrossRefGoogle Scholar
Herzberg, G. R. & Janmohamed, N. (1980). British Journal of Nutrition 43, 571–579.CrossRefGoogle Scholar
Herzberg, G. R. & Rogerson, M. (1980). Nutrition Research 1, 73–82.CrossRefGoogle Scholar
Herzberg, G. R. & Rogerson, M. (1982). Canadian Journal of Physiology and Pharmacology 60, 912–919.CrossRefGoogle Scholar
Hill, R. N., Baker, N. & Chaikoff, I. L. (1954). Journal of Biological Chemistry 209, 705–716.CrossRefGoogle Scholar
Kannan, R., Baker, N. & Bruckdorfer, K. R. (1981). Journal of Nutrition 111, 1216–1223.CrossRefGoogle Scholar
Kornackmer, M. S. & Lowenstein, J. M. (1965). Biochemical Journal 94, 209–215.CrossRefGoogle Scholar
Laurell, S. (1959). Acta Physiologica Scandanavica 47, 218–232.CrossRefGoogle Scholar
Lohr, G. W. & Waller, H. D. (1974). In Methods of Enzymatic Analysis, vol. 1, pp. 636–641 [Bergmeyer, H. U., editor]. New York: Academic Press.CrossRefGoogle Scholar
Lowenstein, J. M. (1970). Journal of Biological Chemistry 246, 629–632.CrossRefGoogle Scholar
MacDonald, I., Keyser, A. & Pacy, J. (1978). American Journal of Clinical Nutrition 31, 1305–1311.CrossRefGoogle Scholar
Maruhama, Y. & MacDonald, I. (1972). Metabolism 21, 835–842.CrossRefGoogle ScholarPubMed
Newgard, C. B., Hirsch, L. J., Foster, D. W. & McGarry, J. D. (1983). Journal of Biological Chemistry 258, 8046–8052.Google Scholar
Niewoehner, C. B., Gilboe, D. P., Nuttall, G. A. & Nuttall, F. Q. (1984). American Journal of Physiology 247, E505–E512.Google Scholar
Nijjar, M. S. & Perry, W. F. (1970). Diabetes 19, 155–160.Google Scholar
Nikilla, E. A. & Ojala, K. (1965). Life Science 4, 937–943.Google Scholar
Nilsson-Ehle, P., Tornqvist, H. & Belfrage, P. (1972). Clinica Chimica Acta 42, 383–390.Google Scholar
Romsos, D. R. & Leveille, G. A. (1974 a). Biochimica et Biophysica Acta 360, 1–11.CrossRefGoogle Scholar
Romsos, D. R. & Leveille, G. A. (1974 b). Advances in Lipid Research 12, 97–146.CrossRefGoogle Scholar
Sleder, J., Chen, Y.-D. I., Cully, M. D. & Reaven, G. M. (1980). Metabolism 29, 303–305.CrossRefGoogle Scholar
Srere, P. A. (1959). Journal of Biological Chemistry 234, 2544–2547.Google Scholar
Sullivan, A. C., Miller, O. N., Wittman, J. S. & Hamilton, J. G. (1971). Journal of Nutrition 101. 265–272.Google Scholar
Suzawa-Katayama, Y. & Morita, N. (1977). Journal of Nutrition 107, 534–538.Google Scholar
Triscari, J., Hamilton, J. G. & Sullivan, A. C. (1978). Journal of Nutrition 108, 815–825.CrossRefGoogle Scholar
Verschoor, L., Chen, Y.-D. I., Reaven, E. P. & Reaven, G. M. (1985). Metabolism 17, 285–288.Google Scholar
Volpe, J. J. & Vagelos, P. R. (1976). Physiological Reviews 58, 339–416.Google Scholar
Waddell, M. & Fallon, H. J. (1973). Journal of Clinical Investigation 52, 2725–2731.CrossRefGoogle Scholar
Wahlfield, A. W. (1974). In Methods of Enzymatic Analysis, vol. 2, pp. 1831–1835 [Bergmeyer, H. U., editor]. New York: Academic Press.Google Scholar
Weinhouse, S. (1976). Current Topics in Cellular Regulation 11, 1–50.CrossRefGoogle Scholar
Yeh, Y. Y., Leveille, G. A. & Wiley, J. H. (1979). Journal of Nutrition 104, 917–924.Google Scholar
Yudkin, J. & Krauss, R. (1967). Nature 215, 75.CrossRefGoogle Scholar
Zavaroni, I.Chen, Y.-D. I. & Reaven, G. M. (1982). Metabolism 31, 1077–1083.Google Scholar
Zavaroni, I., Sander, S., Scott, S. & Reaven, G. R. (1980). Metabolism 29, 970–973.Google Scholar