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Interaction between green tea and metformin and its effects on oxidative stress and inflammation in overweight women: a randomised clinical trial

Published online by Cambridge University Press:  04 November 2024

Carolina de Oliveira Vogado Open the ORCID record for Carolina de Oliveira Vogado [Opens in a new window] ,
Monalisa Alves Ferreira ,
Eduardo Yoshio Nakano ,
Sabrina Azevedo ,
Kelly Grace Magalhães Open the ORCID record for Kelly Grace Magalhães [Opens in a new window] ,
Sandra Fernandes Arruda  and
Patrícia Borges Botelho Open the ORCID record for Patrícia Borges Botelho [Opens in a new window]
Carolina de Oliveira Vogado
Affiliation:
Department of Nutrition, University of Brasília, Brasília, Brazil
Monalisa Alves Ferreira
Affiliation:
Laboratory of Research in Clinical Nutrition and Sports, Nutrition Faculty, Federal University of Goias, Goiania, Goias, Brazil
Eduardo Yoshio Nakano
Affiliation:
Department of Statistics, University of Brasília, Brasília, Brazil
Sabrina Azevedo
Affiliation:
Laboratory of Immunology and Inflammation, Department of Cellular Biology, University of Brasília, Brasília, Brazil
Kelly Grace Magalhães
Affiliation:
Laboratory of Immunology and Inflammation, Department of Cellular Biology, University of Brasília, Brasília, Brazil
Sandra Fernandes Arruda
Affiliation:
Department of Nutrition, University of Brasília, Brasília, Brazil
Patrícia Borges Botelho*
Affiliation:
Department of Nutrition, University of Brasília, Brasília, Brazil
*
*Corresponding author: Patrícia Borges Botelho; email [email protected]
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Abstract

This study evaluated the effect of green tea extract and metformin and its interaction on markers of oxidative stress and inflammation in overweight women with insulin resistance. After screening, 120 women were randomly allocated in 4 groups: Placebo (PC): 1g of microcrystalline cellulose/day; Green tea (GT): 1 g (558 mg polyphenols) of standardized dry extract of green tea/day and 1 g of placebo/day; Metformin (MF): 1 g of metformin/day and 1 g of placebo/day; Green Tea and Metformin (GTMF): 1 g (558 mg polyphenols) and 1 g of metformin/day. All groups were followed-up for 12 weeks with assessment of oxidative damage to lipids and proteins, specific activity of antioxidant enzymes and inflammatory cytokine serum levels. The association of green tea with metformin significantly reduced IL-6 (GTMF: –29.7((–62.6)–20.2))(p = 0.004). Green tea and metformin isolated reduced TNF-α (GT: –12.1((–18.0)–(–3.5)); MF: –24.5((–38.60)–(–4.4)) compared to placebo (PB: 13.8 (1.2–29.2))(P < 0.001). Also, isolated metformin reduced TGF-β (MF: –25.1((–64.4)–0.04)) in comparison to placebo (PB: 6.3((–1.0)–16.3))(p = 0.038). However, when combined, their effects were nullified either for TNF-α (GTMF: 6.0((–5.7)–23.9) and for TGF-β (GTMF: –1.8((–32.1)–8.5). This study showed that there is a drug-nutrient interaction between green tea and metformin that is dependent on the cytokine analyzed.

Keywords

Green teaMetforminInsulin resistanceOverweightInflammationOxidative stress
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 9 , 14 November 2024 , pp. 1173 - 1181
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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