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Inhibition of haem-iron absorption in man by calcium

Published online by Cambridge University Press:  09 March 2007

Leif Hallberg ,
Lena Rossander-Hulthèn ,
Mats Brune  and
Ann Gleerup
Leif Hallberg
Affiliation:
Departnzents of Internal Medicine II and Clinical Nutrition, University of Goteborg, Sahlgren Hospital, S-413 45 Göteborg, Sweden
Lena Rossander-Hulthèn
Affiliation:
Departnzents of Internal Medicine II and Clinical Nutrition, University of Goteborg, Sahlgren Hospital, S-413 45 Göteborg, Sweden
Mats Brune
Affiliation:
Departnzents of Internal Medicine II and Clinical Nutrition, University of Goteborg, Sahlgren Hospital, S-413 45 Göteborg, Sweden
Ann Gleerup
Affiliation:
Departnzents of Internal Medicine II and Clinical Nutrition, University of Goteborg, Sahlgren Hospital, S-413 45 Göteborg, Sweden
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Abstract

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The inhibiting effect of Ca on non-haem-Fe absorption is well established. Presentstudies showed that Ca inhibited haem-Fe absorption to the same extent when the same amount of Ca (165 mg Ca as CaCl2) was added to a meal. Attempts were made to examine the mechanism for this inhibition in the present studies. Meat is the only known dietary factor influencing haem-Fe absorption. The present studies were designed to examine whether Ca interfered with the enhancing effect of meat on haem-Fe absorption. We found that the inhibition was the same whether biosynthetically radio-Fe-labelled haemoglobin wasgiven in meals with or without meat. The haem-Fe absorption ratio with: without added Cawas 0.59 (SE 0.07) when Ca was added to a hamburger meal, and 0.052 (se 0.03) when added to a wheat roll. These values were not significantly different (t 0.95; P = 0.35). The inhibition of haem-Fe absorption by Ca is, thus, a direct effect on theabsorption of haem-Fe and not an indirect counteracting effect of the well-known enhancing effect of meat on haem-Fe absorption. Control studies were conducted to ensure that haem-Fe had not been degraded to non-haem-Fe during preparation of the foods. Since Ca inhibits the absorption of haem- and non-haem-Fe to the same extent, the present results strongly suggest that Ca interferes with the transport of Fe through the mucosal cell, andata late stage, is common for haemand non-haem-Fe transport. The observations that Ca strongly interferes with the absorption of both haem- and non-haem-Fe have important nutritionalimplications.

Keywords

Iron absorptionCalciumManHaem-ironNon-haem-iron
Type
Calcium and Iron Interactions
Information
British Journal of Nutrition , Volume 69 , Issue 2 , March 1993 , pp. 533 - 540
Copyright
Copyright © The Nutrition Society 1993

References

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