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Influence of the diet on the composition of faecal bile acids in rats*

Published online by Cambridge University Press:  09 March 2007

B. E. Gustafsson
Affiliation:
Department of Germfree Research, Karolinska Institutet, Stockholm, Sweden
A. Norman
Affiliation:
Department of Clinical Chemistry, Danderyds Sjukhus, Danderyd, Sweden
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Abstract

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1. [24-14C]cholic acid was given orally to rats receiving three different diets, a semi-synthetic diet (D7) with and without 20% cellulose, and a commercial, pelleted diet. The labelled metabolites excreted in the faeces in the 8 days following administration of the labelled cholic acid were chromatographically separated, and tentatively identified by means of thin-layer chromatography.

2. In all three dietary groups the faecal bile acids mainly consisted of unconjugated and 7α-dehydroxylated metabolites. In rats receiving pellets or diet D7 with cellulcse, there was a higher percentage of monohydroxy-monoketo-cholanoic acids than in those receiving diet D7 alone. Dihydroxy-cholanoic acids, present in approximately the same ratio as were the 3α- and 3β-hydroxy isomers, were excreted by all the rats in the three dietary groups.

Type
Research Article
Copyright
Copyright © The Nutrition Society 1969

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