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The influence of α-linolenic acid (18: 3ω3) on the metabolism of γ-linolenic acid (18: 3ω6) in the rat

Published online by Cambridge University Press:  09 March 2007

A. G. Hassam
A. G. Hassam*
Affiliation:
Department of Biochemistry, Nuffield Institute of Comparative Medicine, The Zoological Society of London, Regent's Park, London NW1 4RY
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Abstract

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  1. 1. Essential fatty acid-deficient rats were fed γ-linolenic acid (18:3ω6) at 2 % dietary energy and α-linolenic acid (18:3ω3) at 0, 1.6, 2.8 and 4.0 % of the dietary energy.

  2. 2. 18:3ω3 at 1.6% apparently inhibits the synthesis of the C20 and C22 ω6 long-chain polyunsaturated fatty acids (ω6 LC-PUFA) metabolized from 18:3ω6.

  3. 3. However, increasing the dietary levels of 18:3ω3 from 1.6 to 4.0% has no further influence.

  4. 4. The results suggest that dietary 18:3ω6 is an efficient precursor for the ω6 LC-PUFA synthesis even in the presence of 18:3ω3.

Type
Short Papers
Information
British Journal of Nutrition , Volume 38 , Issue 1 , July 1977 , pp. 137 - 140
Copyright
Copyright © The Nutrition Society 1977

References

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