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Influence of Korean pine (Pinus koraiensis)-seed oil containing cis-5,cis-9, cis-12-octadecatrienoic acid on polyunsaturated fatty acid metabolism, eicosanoid production and blood pressure of rats

Published online by Cambridge University Press:  06 August 2007

Michihiro Sugano ,
Ikuo Ikeda ,
Kosaburo Wakamatsu  and
Takayuki Oka
Michihiro Sugano
Affiliation:
Laboratory of Food Science Kyushu University School of Agriculture, Fukuoka 812, Japan
Ikuo Ikeda
Affiliation:
Laboratory of Nutrition Chemistry. Kyushu University School of Agriculture, Fukuoka 812, Japan
Kosaburo Wakamatsu
Affiliation:
Laboratory of Nutrition Chemistry. Kyushu University School of Agriculture, Fukuoka 812, Japan
Takayuki Oka
Affiliation:
Laboratory of Nutrition Chemistry. Kyushu University School of Agriculture, Fukuoka 812, Japan
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Abstract

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The effects of dietary Korean pine (Pinus koraiensis)-seed oil containing a peculiar trienoic acid (cis-5, cis-9,cis-12-18:3, pinolenic acid, approximately 18%) on various lipid variables were compared in rats with those of flaxseed (Linum usitatissimum L.) oil, safflower (Carthamus tinctorius L.) oil and evening primrose (Oenothera biennis L.) oil under experimental conditions where the effects of different polyunsaturated fatty acids could be estimated. In Sprague-Dawley rats fed on diets containing 100 g fat and 5 g cholesterol/kg, the hypocholesterolaemic activity of pinolenic acid was intermediate between α-linolenic and linoleic acids. Analysis of the fatty acid composition of liver phosphatidylcholine indicated that, in contrast to α-linolenic acid, pinolenic acid does not interfere with the desaturation of linoleic acid to arachidonic acid. However, the effects on ADP-induced platelet aggregation and aortic prostacyclin production were comparable. When spontaneously hypertensive rats were fed on diets containing 100 g fat/kg but free of cholesterol, γ-linolenic and pinolenic acids, as compared with linoleic acid, increased prostacyclin production and tended to reduce platelet aggregation. In addition, pinolenic acid attenuated the elevation of blood pressure after 5 weeks of feeding. Thus, the results of the present studies indicate the beneficial effects of pinolenic acid on various lipid variables.

Keywords

Pine-seed oilLipid metabolismPlatelet aggregationHypertension
Type
Korean pine oil and lipid metabolism
Information
British Journal of Nutrition , Volume 72 , Issue 5 , November 1994 , pp. 775 - 783
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

American Institute of Nutrition (1977). Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. Journal of Nutrition 107, 1340–1348.Google Scholar
Berger, A. & German, J. B. (1991). Extensive incorporation of dietary ▵-5,11,14 eicosatrienoate into the phosphatidylinositol pool. Biochimica et Biophysica Acta 1085, 371–376.CrossRefGoogle ScholarPubMed
Brenner, R. R. (1989). Factors influencing fatty acid chain elongation and desaturation. In The Role of Fats in Human Nutrition, 2nd ed., pp. 45–79 [Vergroesen, A.J. and Crawford, M., editors]. London: Academic Press.CrossRefGoogle Scholar
Brox, J. H., Killie, J. E., Gunnes, S. & Nordoy, A. (1981). The effect of cod liver oil and corn oil on platelets and vessel wall in man. Thrombosis and Haemostasis 46, 604–611.Google ScholarPubMed
Duncan, D. B. (1955). Multiple range and multiple F tests. Biometrics 11, 1–42.CrossRefGoogle Scholar
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957). A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226, 497–506.Google Scholar
Hoffman, P. & Foster, W. (1983). Effect of sunflowerseed oil, linseed oil, evening primrose oil and hydrogenated palm kernel oil on hypertension development in spontaneously hypertensive rats. Prostaglandins Leukotrienes and Medicine 11, 43–44.Google Scholar
Houtsmuller, U. M. T. (1981). Columbinic acid, a new type of essential fatty acid. Progress in Lipid Research 20, 889–896.CrossRefGoogle ScholarPubMed
Ibrahim, J. B. T. & McNamara, D. J. (1988). Cholesterol homeostasis in guinea pigs fed saturated and polyunsaturated fat diets. Biochimica et Biophysica Acta 963, 109–118.CrossRefGoogle ScholarPubMed
Ikeda, I., Oka, T., Koba, K., Sugano, M. & Lie, Ken, Jie, M. S. F. (1992). 5c-, 11c-, 14c-eicosatrienoic acid and 5c-, 11c-, 14c-, 17c-eicosatetraenoic acid of Biota orientalis seed oil affect lipid metabolism in the rat. Lipids 27, 500–504.Google Scholar
Ikeda, I., Tomari, Y. & Sugano, M. (1989). Interrelated effects of dietary fiber and fat on lymphatic cholesterol and triglyceride absorption in rats. Journal of Nutrition 119, 1383–1387.Google Scholar
Kinsella, J. E., Broughton, K. S. & Whelan, J. W. (1990). Dietary unsaturated fatty acids: interactions and possible needs in relation to eicosanoid synthesis. Journal of Nutritional Biochemistry 1, 123–141.Google Scholar
Knapp, H. R. (1989). Omega-3 fatty acids, endogenous prostaglandins, and blood pressure regulation in humans. Nutrition Reviews 47, 301–313.Google Scholar
Koba, K., Abe, K., Ikeda, I. & Sugano, M. (1992). Effects of α-tocopherol and tocotrienols on blood pressure and linoleic acid metabolism in the spontaneously hypertensive rat (SHR). Bioscience Biotechnology and Biochemistry 56, 1420–1423.Google Scholar
Lands, W. E. M. (1991). Biosynthesis of prostaglandins. Annual Review of Nutrition 11, 41–60.Google Scholar
Lee, J. H., Fukumoto, M., Nishida, H., Ikeda, I. & Sugano, M. (1989). The interrelated effects of n-6/n-3 and polyunsaturated/saturated ratios of dietary fats on the regulation of lipid metabolism in rats. Journal of Nutrition 119, 1893–1899.Google Scholar
Lee, J. H., Ikeda., I. & Sugano, M. (1991). Dietary cholesterol influences on various lipid indices and eicosanoid production in rats fed dietary fat desirable for the protection of ischemic heart disease. Journal of Nutritional Science and Vitaminology 37, 389–399.Google Scholar
Subbiah, M. T. R. (1978). Prostaglandin E2 biosynthesis and effect in pigeon aorta. Atherosclerosis 29, 487–495.Google Scholar
Sugano, M., Kamo, F., Ikeda, I. & Morioka, H. (1976). Lipid-lowering activity of phytosterols in rats. Atherosclerosis 24, 301–309.Google Scholar
Sugano, M. & Lee, J. H. (1989). Nutritional and physiological significance of lipids. Journal of Dispersion Science and Technology 10, 643–665.Google Scholar
Sugano, M., Morioka, H. & Ikeda, I. (1977). A comparison of hypocholesterolemic activity of β-sitosterol and β-sitostanol in rats. Journal of Nutrition 107, 2011–2019.Google Scholar