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The influence of creatinine, lecithin and choline feeding on aliphatic amine production and excretion in the rat

Published online by Cambridge University Press:  09 March 2007

Susan Lowis ,
M. A. Eastwood  and
W. G. Brydon
Susan Lowis
Affiliation:
Wolfson Gastrointestinal Laboratory, Gastrointestinal Unit, Department of Medicine, Western General Hospital, Edinburgh EH4 2XU
M. A. Eastwood
Affiliation:
Wolfson Gastrointestinal Laboratory, Gastrointestinal Unit, Department of Medicine, Western General Hospital, Edinburgh EH4 2XU
W. G. Brydon
Affiliation:
Wolfson Gastrointestinal Laboratory, Gastrointestinal Unit, Department of Medicine, Western General Hospital, Edinburgh EH4 2XU
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Abstract

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1. The excretion of aliphatic amines, methylamine, dimethylamine and trimethylamine in the urine and faeces of rats fed on a control diet and diets supplemented with creatinine, lecithin or choline were measured over a 14 d feeding period.

2. The rats were then killed and concentrations of amines in small and large intestinal contents measured.

3. Adding creatinine to the diet resulted in a significant increase of methylamine excretion in the faeces and urine. The amount of methylamine found in all parts of the intestine increased, especially in the caecum.

4. Adding lecithin to the diet resulted in an increase in the methylamine excretion only, and no change in the concentrations of amines found in the intestine, except for trimethylamine which was significantly increased in the caecum and colon.

5. Adding choline to the diet resulted in a significant increase in excretion of trimethylamine and, to a lesser extent, methylamine. The levels of amines found in the gut increased, dimethylamine being increased in the small bowel, and methylamine and trimethylamine in the caecum.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 1 , July 1985 , pp. 43 - 51
Copyright
Copyright © The Nutrition Society 1985

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