Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-25T18:40:29.308Z Has data issue: false hasContentIssue false
  • English
  • Français

Influence of chronic ethanol intake on obesity, liver steatosis and hyperlipidaemia in the Zucker fa/fa rat

Published online by Cambridge University Press:  09 March 2007

C. Karsenty ,
F. Chanussot ,
M. Ulmer  and
G. Debry
C. Karsenty
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I' Université de Nancy I et Unité de Recherches de Nutrition et Diététique de P' INSERM U. 59, 40 rue Lionnois, F-54000 Nancy, France
F. Chanussot
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I' Université de Nancy I et Unité de Recherches de Nutrition et Diététique de P' INSERM U. 59, 40 rue Lionnois, F-54000 Nancy, France
M. Ulmer
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I' Université de Nancy I et Unité de Recherches de Nutrition et Diététique de P' INSERM U. 59, 40 rue Lionnois, F-54000 Nancy, France
G. Debry
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I' Université de Nancy I et Unité de Recherches de Nutrition et Diététique de P' INSERM U. 59, 40 rue Lionnois, F-54000 Nancy, France
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The effect of chronic alcohol intoxication on metabolic disturbances and fatty infiltration and degeneration was studied in genetically obese, hyperlipoproteinaemic, fa/fa Zucker rats.

2. Sixteen obese Zucker (fa/fa) rats, sixteen lean Zucker rats (Fa/-)and sixteen Wistar rats, all male rats aged 7–8 weeks, were given either a control (C)diet (13% of energy from protein, 37% from fat, 50% from carbohydrate) or an ethanol (E) diet (13% of energy from protein, 37% from fat, 14% from carbohydrate, 36% from ethanol) for 4 weeks.

3. The fa/fa rats given diet E consumed more energy than those given diet C, but after 4 weeks the weight gains and degrees of obesity were similar for both groups. With both diets, the developed hyperlipidaemia could be explained by the hyperinsulinaemia. Both hypertriglyceridaemia and hypercholesterolaemia were lower in fa/fa rats eating diet E than in those given diet C. Fatty infiltration of the liver, as assessed by hepatic triacylglycerol and cholesterol contents, was observed with both diets, but for fa/fa rats it was less extreme in those given diet E.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 1 , July 1985 , pp. 5 - 13
Copyright
Copyright © The Nutrition Society 1985

References

Bach, A., Schirardin, H., Chanussot, F., Bauer, M. & Weryha, A. (1980). Journal of Nutrition 110, 686–696.CrossRefGoogle Scholar
Baraona, E. & Lieber, C. S. (1979). Journal of Lipid Research 20, 289–315.CrossRefGoogle Scholar
Beaufay, H., Amar-Costesec, A., Feytmans, E., Thines-Sempoux, D., Wibo, M., Robi, M. & Berthet, J. (1974). Journal of Cell Biology 61, 188–212.CrossRefGoogle Scholar
Bray, G.A. & York, D. A. (1979). Physiological Reviews 59, 719–809.CrossRefGoogle Scholar
De Carli, L. M. & Lieber, C. S. (1967). Journal of Nutrition 91, 331–336.CrossRefGoogle Scholar
De Waard, H. (1978). Nederlands Instituut Voor Zuivelonderzoek. Ede. 112 pp.Google Scholar
Herbert, Y., Lau, K., Gottlieb, C. W. & Bleicher, S. J. (1965). Journal of Clinical Endocrinology 25, 1375–1384.CrossRefGoogle Scholar
Hirayama, C., Nosaka, Y., Yamada, S. & Yamanishi, Y. (1979). Research Communications in Chemical Pathology and Pharmacology 26, 563–569.Google Scholar
Joly, J. G., Feinman, L., Ishii, H. & Lieber, C. S. (1973). Journal of Lipid Research 14, 337–343.CrossRefGoogle Scholar
Karsenty, C., Ulmer, M., Chanussot, F., Ratanasavanb, R. & Debry, G. (1985). British Journal of Nutrition 54, 15–20.CrossRefGoogle Scholar
Klose, S., Hagen, A. & Greif, H. (1975). Organisation des Laboratoires. Biologie Prospective. Troisième colloque de Pont-à-Mousson, pp. 505–507 [Siest, G., editor]. Paris: L'Expansion Scientifique Française.Google Scholar
Laksmanan, M. R. & Veech, R. L. (1977). Journal of Lipid Research 18, 325–330.CrossRefGoogle Scholar
Laube, H., Klöz, H. U., Fussgänger, R. & Pfeiffer, E. F. (1973). Nutrition and Metabolism 15, 273–280.CrossRefGoogle Scholar
Lederer, J., Niethals, E., Pottier-Arnould, A. M. & Delhaye-Pottier, C. (1978). Revue de l' Alcoholisme 24, 165–171.Google Scholar
Lefevre, A. F., De Carli, L. M. & Lieber, C. S. (1972). Journal of Lipid Research 13, 48–55.CrossRefGoogle Scholar
Lieber, C. S., Jones, D. P. & De Carli, L. M. (1965). Journal of Clinical Investigation 44, 1009–1021.CrossRefGoogle Scholar
Michaelis, D. E., Scholfield, D. J., Gardner, L. B. & Cataland, S. (1980). Journal of Nutrition 110, 1409–1420.CrossRefGoogle Scholar
Ozelci, A., Romsos, D. R. & Leveille, G. A. (1978). Journal of Nutrition 108, 1128–1136.CrossRefGoogle Scholar
Pirola, R. C. & Lieber, C. S. (1972). Pharmacology 7, 185–196.CrossRefGoogle Scholar
Redgrave, T. G. & Martin, G. (1977). Atherosclerosis 28, 69–80.CrossRefGoogle Scholar
Reiser, S. & Hallfrisch, J. (1977). Journal of Nutrition 107, 147–155.CrossRefGoogle Scholar
Reitz, R. C. (1979). Progress in Lipid Research 18, 87–115.CrossRefGoogle Scholar
Trinder, P. (1969). Annals of Clinical Biochemistry 6, 24–27.CrossRefGoogle Scholar
Wahlefeld, A. W. (1974). Methods of Enzymatic Analysis, vol. IV, 2nd ed., pp. 1831–1835. [Bergmeyer, H. U., editor]. London and New York: Academic Press.CrossRefGoogle Scholar
Zlatkis, A., Zak, B. & Boyle, A. S. (1953). Journal of Laboratory and Clinical Medicine 41, 486–492.Google Scholar