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The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women

Published online by Cambridge University Press:  09 March 2007

John H. Beattie  and
Heather S. Peace
John H. Beattie
Affiliation:
Division of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Heather S. Peace
Affiliation:
Division of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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An increase in dietary intake of B from 0.25 to 3.25 mg/d has been reported to increase plasma oestradiol and testosterone and decrease urinary Ca excretion in postmenopausal women. Consequently, it is suggested that the higher level of B intake could reduce bone loss associated with the menopause and cessation of ovarian function. The present study was designed to investigate the effect of a B supplement on bone mineral absorption and excretion, plasma sex steroid levels and urinary excretion of pyridinium crosslink markers of bone turnover in healthy postmenopausal volunteers. The women were accommodated in a metabolic unit, given a low-B diet (LBD; 0.33 mg/d) for 3 weeks and were asked to take a B supplement of 3 mg/d in addition to the LBD for a further 3 weeks. Changing B intake from 0.33 to 3.33 mg/d had no effect on minerals, steroids or crosslinks. However, the LBD appeared to induce hyperabsorption of Ca since positive Ca balances were found in combination with elevated urinary Ca excretion. This phenomenon may have inhibited or obscured any effect of B.

Keywords

BoronCalciumBone turnover
Type
Mineral Metabolism
Information
British Journal of Nutrition , Volume 69 , Issue 3 , May 1993 , pp. 871 - 884
Copyright
Copyright © The Nutrition Society 1993

References

Barbosa, J. C., Shultz, T. D., Filley, S. J. & Nieman, D. C. (1990). The relationship among adiposity, diet, and hormone concentrations in vegetarian and non-vegetarian postmenopausal women. American Journal of Clinical Nutrition 51, 798–803.CrossRefGoogle Scholar
Beattie, J. H. & Macdonald, A. (1991). Effect of boron on bone metabolism in rats. In Trace Elements in Man and Animals no. 7, pp, 2629–2630 [Momcilovic, B., editor]. Zagreb: IMI Press.Google Scholar
Beattie, J. H. & Weersink, E. (1992). Borate and molybdate inhibition of catechol oestrogen and pyrocatechol methylation by catechol-O-methyltransferase. Journal of Inorganic Biochemistry 46, 153–160.CrossRefGoogle ScholarPubMed
Black, D., Farquharson, C. & Robins, S. P. (1989). Excretion of pyridinium cross-links of collagen in ovariectomized rats urinary markers for increased bone resorption. Calcified Tissue International 44, 343–347.CrossRefGoogle ScholarPubMed
Bosnes, R. W. & Taussky, H. H. (1945). On the colorimetric determination of creatinine by the Jaffe reaction. Journal of Biological Chemistry 158, 581–591.CrossRefGoogle Scholar
Bremner, I. (1991). A molecular approach to the study of copper and zinc metabolism. In Trace Elements in Man and Animals no. 7, pp. 1.1–1.3 [Momcilovic, B., editor]. Zagreb: IMI Press.Google Scholar
Dreosti, I. E. (1986). Magnesium (review). Journal of Food and Nutrition 42, 59–67.Google Scholar
Fiske, C. H. & Subbarow, Y. (1925). The colorimetric determination of phosphorous. Journal of Biological Chemistry 66(2), 375–399.CrossRefGoogle Scholar
Gitelman, H. J. (1967). An improved automated procedure for the determination of calcium in biological specimens. Analytical Biochemistry 18, 521–531.CrossRefGoogle Scholar
Gitelman, H. J., Hurt, C. & Lutwak, L. (1966). An automatic spectrophotometric method for magnesium analysis. Analytical Biochemistry 14, 106–120.CrossRefGoogle Scholar
Goldin, B. R., Adlercreutz, H., Gorbach, S. L., Warram, J. H., Dwyer, J. T., Swenson, L. & Woods, M. N. (1982). Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women. New England Journal of Medicine 307, 1542–1547.CrossRefGoogle ScholarPubMed
Hamilton, E. I. & Minski, M. J. (1972). Abundance of the chemical elements in man's diet and possible relations with environmental factors. Science of the Total Emironment 1, 375–394.CrossRefGoogle Scholar
Hegsted, M., Keenan, M. J., Siver, F. & Wozniak, P. (1991). Effect of boron on vitamin D deficient rats. Biological Trace Element Research 28, 243–255.CrossRefGoogle ScholarPubMed
Hunt, C. D. (1989). Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick. Biological Trace Element Research 22, 201–220.CrossRefGoogle ScholarPubMed
Hunt, C. D. & Nielsen, F. H. (1981). Interaction between boron and cholecalciferol in the chick. In Trace Elements in Man and Animals no. 4, pp. 597–600 [Howell, J. McC. and Gawthorne, J. M., editors]. Canberra: Australian Academy of Science.CrossRefGoogle Scholar
Hunt, C. D. & Nielsen, F. H. (1988). Dietary boron affects calcification in magnesium and cholecalciferol deficient chicks. In Trace Elements in Man and Animals no. 6, pp. 275–276 [Hurley, L. S., Keen, C. L., Lonnerdal, B. and Rucker, R. B., editors]. New York: Plenum Press.CrossRefGoogle Scholar
Hutton, J. D., Jacobs, H. S. & James, V. H. T. (1979). Steroid endocrinology after the menopause: a review. Journal of the Royal Society of Medicine 72, 835–841.CrossRefGoogle ScholarPubMed
Jackson, J. F. & Chapman, K. S. R. (1975). The role of boron in plants. In Trace Elenients in Soil-plunt-cmirnrrl Systems, pp. 213–225 [Nicolas, D. J. D. and Egan, A. R., editors]. New York: Academic Press.Google Scholar
Jansen, J. A., Andersen, J. & Schou, J. S. (1984). Boric acid single dose pharmacokinetics after intravenous administration to man. Archives of Toxicology 55, 6467.CrossRefGoogle ScholarPubMed
Kent, N. L. & McCance, R. A. (1941). The absorption and excretion of ‘minor’ elements by man. I. Silver, gold, lithium, boron and vanadium. Biochemical Journal 35, 837–844.CrossRefGoogle Scholar
Koivistoinen, P. (editor) (1980). Mineral element composition of Finnish foods: N, K, Ca, Mg, P, S, Fe, Cu, Mn, Zn, Mo, Co, Ni, Cr, F, Se, Si, Rb, Al, B, Br, Hg, As, Cd, Pb and Ash. Acta Agriculturae Scundanavica 22, Suppl.Google Scholar
Lakshmanan, F. L., Rao, R. B., Kim, W. W. & Kelsay, J. L. (1984). Magnesium intakes, balances, and blood levels of adults consuming self-selected diets. American Journal of Clinical Nutrition 40, 1380–1389.CrossRefGoogle ScholarPubMed
Nielsen, F. H. (1988). Boron an overlooked element of potential nutritional importance. Nutrition Today pp. 4–7.CrossRefGoogle Scholar
Nielsen, F. H., Hunt, C. D., Mullen, L. M. & Hunt, J. R. (1987). Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB Journal 1, 394–397.CrossRefGoogle ScholarPubMed
Nielsen, F. H., Mullen, L. M. & Gallagher, S. K. (1990). Effect of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium-low diet. Journal of Trace Elements in Experimental Medicine 3, 45–54.Google Scholar
Nielsen, F. H., Shuler, T. R., Zimmerman, T. J. & Uthus, E. O. (1988). Magnesium and methionine deprivation affect the response of rats to boron deprivation. Biological Trace Element Research 17, 91–107.CrossRefGoogle ScholarPubMed
Paul, A. A. & Southgate, D. A. T. (1978). McCance and Widdowson's, The Composition of Foods, 4th ed. London: H.M. Stationery Office.Google Scholar
Peace, H. & Beattie, J. H. (1991). No effect of boron on bone mineral excretion and plasma sex steroid levels in healthy postmenopausal women. In Trace Elements in Man and Animals no. 7, pp. 8.1–8.2 [Momcilovic, B., editor] Zagreb: IMI Press.Google Scholar
Rae, M. H., Mole, P. A. & Paterson, C. R. (1988). Evaluation of urinary oestrogen assays after the menopause and their potential for screening. Clinica Chimica Acta 176, 71–82.CrossRefGoogle ScholarPubMed
Reed, M. J. & Murray, M. A. F. (1979). The Oestrogens. In Hormones in Blood, pp. 263–353 [Gray, C. H. and James, V. H. T., editors] London: Academic Press.Google Scholar
Robins, S. P., Duncan, A. & Riggs, B. L. (1990). Direct measurement of free hydroxypyridinium crosslinks of collagen in urine as new markers of bone resorption in osteoporosis. In Osteoporosis pp.465–468 [Christiansen, C. and Overgaard, K., editors]. Copenhagen: Osteopress ApS.Google Scholar
Robins, S. P., Black, D., Paterson, C. R., Reid, D. M., Duncan, A. & Seibel, M. J. (1991). Evaluation of urinary hydroxypyridinium crosslink measurements as resorption markers in metabolic bone diseases. European Journal of Clinical Investigation 21, 310–315.CrossRefGoogle ScholarPubMed
Seibel, M. J., Duncan, A. & Robins, S. P. (1989). Urinary hydroxypyridinium crosslinks provide indices of cartilage and bone involvement in arthritic diseases. Journal of Rheumatology 16, 964–970.Google ScholarPubMed
Ubelhardt, D., Schlemmer, A., Johansen, J. S., Gineyets, E. C., Christiansen, C. & Delmas, P. D. (1991). Effect of menopause and estrogen treatment on the urinary excretion of pyridinium crosslinks. Journal of Clinical Endocrinology and Metabolism 72, 367–373.CrossRefGoogle Scholar