Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-30T02:33:58.132Z Has data issue: false hasContentIssue false
  • English
  • Français

Independent jejunal mechanisms for glycine and glycylglycine transfer in man in vivo

Published online by Cambridge University Press:  09 March 2007

G. C. Cook
G. C. Cook
Affiliation:
Department of Medicine, The University of Zambia, PO Box 2379, Lusaka, Zambia
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Rates of absorption of glycine and glycylglycine from a 300 mm jejunal segment were compared in vivo when those compounds were given alone or together to six Zambian African subjects who had no clinical evidence of malnutrition or of gastro-intestinal disease. Solutions containing (A) glycine (100 mmol/1), (B) glycine (100 mmol/l)+glycylglycine (50 mmol/l), and (C) glycylglycine (50 mmol/l) were infused into the upper jejunum by means of a double-lumen tube perfusion system.

2. Rate of absorption of glycine was significantly higher from the glycylglycine solution (C) than from the glycine solution (A). Glycine absorption rate from solution B (glycine+glycylglycine) was very similar to the sum of absorption rates of glycine from solutions A and C in each subject. Luminal disappearance rate of glycylglycine from solutions C and B were very similar; however, the rate was significantly greater than the total glycine absorption rate from solution C and indicates back-diffusion of glycine into the lumen after glycylglycine hydrolysis.

3. The results are interpreted as indicating that the transport mechanisms for glycine and glycylglycine in man are partly, and possibly wholly, separate.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 30 , Issue 1 , July 1973 , pp. 13 - 19
Copyright
Copyright © The Nutrition Society 1973

References

Asatoor, A. M., Cheng, B., Edwards, K. D. G., Lant, A. F., Matthews, D. M., Milne, M. D., Navab, F. & Richards, A. J. (1970). Gut 11, 380.CrossRefGoogle Scholar
Brelsford, W. V. (1965). The Tribes of Zambia. Lusaka, Zambia: Government Printer.Google Scholar
Cook, G. C. (1971). J. Physiol, Lond. 217, 61.CrossRefGoogle Scholar
Cook, G. C. (1972 a). Clin. Sci. 42, 525.CrossRefGoogle Scholar
Cook, G. C. (1972 b). Clin. Sci. 43, 443.CrossRefGoogle Scholar
Cook, G. C. (1973). Br. J. Nutr., 29, 377.CrossRefGoogle Scholar
Cook, G. C., Kajubi, S. K. & Lee, F. D. (1969). J. Path. 98, 157.CrossRefGoogle Scholar
Craft, I. L., Geddes, D., Hyde, C. W., Wise, I. J. & Matthews, D. M. (1968). Gut 9, 425.CrossRefGoogle Scholar
Crampton, R. F., Gangolli, S. D., Simson, P. & Matthews, D. M. (1971). Clin. Sci. 41, 409.CrossRefGoogle Scholar
Giroux, J. & Puech, A. (1963). Annls pharm. fr. 21, 469.Google Scholar
Hydén, S. (1955). K. Lantbr Högsk. Annlr. 22, 139.Google Scholar
Lineweaver, H. & Burk, D. (1934). J. Am. Chem. Soc. 56, 658.CrossRefGoogle Scholar
Lis, M. T., Crampton, R. F. & Matthews, D. M. (1972). Br. J. Nutr. 27, 159.CrossRefGoogle Scholar
Matthews, D. M. (1971). J. clin. Path. 24, Suppl. no. 5, p. 29.CrossRefGoogle Scholar
Matthews, D. M., Craft, I. L., Geddes, D. M., Wise, I. J. & Hyde, C. W. (1968). Clin. Sci. 35, 415.Google Scholar
Matthews, D. M., Lis, M. T., Cheng, B. & Crampton, R. F. (1969). Clin. Sci. 37, 751.Google Scholar
Newey, H. & Smyth, D. H. (1962). J. Physiol., Lond. 164, 527.CrossRefGoogle Scholar
Nixon, S. E. & Mawer, G. E. (1970). Br. J. Nutr. 24, 241.CrossRefGoogle Scholar
Peters, T. J. (1970). Gut 11, 720.CrossRefGoogle Scholar
Rubino, A., Field, M. & Shwachman, H. (1970). Pediat. Res. 4, 477.CrossRefGoogle Scholar