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Increased glycine absorption rate associated with acute bacterial infections in man

Published online by Cambridge University Press:  09 March 2007

G. C. Cook
G. C. Cook
Affiliation:
Department of Medicine, The University of Zambia, P.O. Box 2379, Lusaka, Zambia
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Abstract

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1. Glycine absorption rate from a 300 mm jejunal segment was determined in vivo in four Zambian African subjects with acute, and four with chronic, respiratory infections. Glycine solutions (100, 150 and 250 mmol/l) were perfused, by means of a double-lumen tube technique. The results were compared with those for four relatively normal Zambian African subjects (‘reference’ group) previously studied. The group with acute-infections had a significantly higher mean absorption rate than the reference or chronic-infection group.

2. Glycine absorption results from a 100 mmol/l glycine solution in an additional twenty-four Zambian African subjects have also been analysed. When results for the thirty-six subjects were combined, those with acute bacterial infections had a significantly higher mean absorption rate than the normal subjects or those with chronic infections. For the twenty-one normal subjects there was a significant positive correlation between the individual absorption rates and serum total globulin and γ-globulin concentrations.

3. It seems likely that the rapid catabolism of protein associated with infection is counteracted by an increase in amino acid absorption rate. In subjects on a low-protein diet that mechanism would be limited. The deterioration in nutritional status during infections in developing countries could therefore be partly explained by the present observation.

Type
Research Article
Information
British Journal of Nutrition , Volume 29 , Issue 3 , May 1973 , pp. 377 - 386
Copyright
Copyright © The Nutrition Society 1973

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