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Impact of maternal iron deficiency on quality and quantity of milk ingested by neonatal rats

Published online by Cambridge University Press:  09 March 2007

Deborah L. O'Connor ,
Mary Frances Picciano  and
Adria R. Sherman
Deborah L. O'Connor
Affiliation:
School of Human Resources and Family Studies and Division of Nutritional Sciences, College of Agriculture, University of Illinois, Urbana, IL 61801, USA
Mary Frances Picciano
Affiliation:
School of Human Resources and Family Studies and Division of Nutritional Sciences, College of Agriculture, University of Illinois, Urbana, IL 61801, USA
Adria R. Sherman
Affiliation:
School of Human Resources and Family Studies and Division of Nutritional Sciences, College of Agriculture, University of Illinois, Urbana, IL 61801, USA
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Abstract

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1. The effect of maternal iron deficiency on milk composition and consumption by sucking rats was investigated.

2. Dams (n 42) were fed on semi-purified diets with either 8 (Fe-) or 250 (Fe+) mg Fe as ferrous sulphate/kg throughout gestation and lactation. Total milk intake was determined at days 7, 12 and 17 of lactation from the rate of disappearance of 3H2O from the total body water pool of pups. Measurements of milk constituents and Fe status of animals also were made.

3. Feeding the Fe- diet led to the development of anaemia in dams and pups and to growth retardation of sucking pups.

4. Concentrations of total lipid and Fe in milk from Fe- dams were significantly lower than those from Fe + dams. Mean milk intakes (ml/d) of Fe-deficient pups were 21 and 28% less than intakes of Fe-sufficient pups on days 12 and 17 respectively. However, when expressed per kg body-weight, mean milk intakes were similar between groups on days 17 and 12 and increased by 47% in the Fe-deficient group on day 17 of lactation.

5. It is concluded that maternal Fe deficiency affects the quality of milk ingested by neonatal rats. However, Fe-deficient pups are at least partially able to compensate for reduced milk energy and nutrient contents by increasing intake in late lactation.

Type
Other Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 60 , Issue 3 , November 1988 , pp. 477 - 485
Copyright
Copyright © The Nutrition Society 1988

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