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Immunobiology of gestational zinc deficiency

Published online by Cambridge University Press:  09 March 2007

Nele Wellinghausen
Nele Wellinghausen*
Affiliation:
Department of Medical Microbiology and Hygiene, University of Ulm, Robert-Koch-Str. 8, D-89081 Ulm, Germany
*
Corresponding author: Dr Nele Wellinghausen, fax +49 731 502 3473, email [email protected]
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Abstract

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The trace element zinc is an essential micronutrient for the proper functioning of the immune system. Zinc deficiency leads to impaired function of the unspecific and specific immune response and consequently to an increased susceptibility to bacterial, viral and fungal infections. Immunological defects are not only seen in pronounced but even in marginal and moderate zinc deficiency. Lack of zinc is especially harmful for the development of the immune system, which stresses the importance of a balanced zinc level during pregnancy. However, gestational zinc deficiency due to an imbalance between intake and increased requirements is a common problem world-wide. In animals, gestational zinc deficiency results in reduced thymic and spleen size and depressed active and passive immunity in the infant. For example, depressed immunoglobulin levels, altered antibody repertoire, reduced proliferative response of lymphocytes and diminished neutrophil functions have been reported. Interestingly, immune defects caused by prenatal zinc deficiency, such as depressed antibody levels and lymphocyte proliferation, may even persist in subsequent generations and are not reversible by postnatal zinc administration. Since gestational zinc deficiency is a common problem throughout all cultures and socioeconomic levels, it might have immense consequences for the health status of the population. Based on a summary of the immunobiology of zinc, this article reviews the significance of zinc deficiency during pregnancy and the effect of gestational zinc deficiency on passive and active immunity in the infant. It provides a rational basis for both immunological laboratory investigations and field studies, such as large community-based zinc supplementation trials in pregnant women.

Keywords

Zinc deficiencyPregnancyZinc supplementationImmunology
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue S2 , May 2001 , pp. S81 - S86
Copyright
Copyright © The Nutrition Society 2001

References

Bach, JF (1981) The multi-faceted zinc dependency of the immune system. Immunology Today 4, 225–227.CrossRefGoogle Scholar
Bedwal, RS & Bahuguna, A (1994) Zinc, copper and selenium in reproduction. Experientia 50, 626–640.CrossRefGoogle ScholarPubMed
Beach, RS, Gershwin, ME & Hurley, LS (1982 a) Reversibility of development retardation following murine fetal zinc deprivation. Journal of Nutrition 112, 1169–1181.CrossRefGoogle ScholarPubMed
Beach, RS, Gershwin, ME & Hurley, LS (1982 b) Gestational zinc deprivation in mice: persistence of immunodeficiency for three generations. Science 218, 469–471.CrossRefGoogle ScholarPubMed
Beach, RS, Gershwin, ME & Hurley, LS (1983) Persistent immunological consequences of gestational zinc deprivation. American Journal of Clinical Nutrition 38, 579–590.CrossRefGoogle ScholarPubMed
Black, RE (1998) Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. American Journal of Clinical Nutrition 68, 476S-479S.CrossRefGoogle ScholarPubMed
Briefel, RR, Bialostosky, K, Kennedy-Stephenson, J, McDowell, MA, Ervin, RB & Wright, JD (2000) Zinc intake of the US population: findings from the third National Health and Nutrition Survey, 1988–1994. Journal of Nutrition 130, 1367S-1373S.CrossRefGoogle ScholarPubMed
Caulfield, LE, Zavaleta, N, Shankar, AH & Merialdi, M (1998) Potential contribution of maternal zinc supplementation during pregnancy to maternal and child survival. American Journal of Clinical Nutrition 68, 499S-508S.CrossRefGoogle ScholarPubMed
Caulfield, LE, Zavaleta, N & Figueroa, A (1999 a) Adding zinc to prenatal iron and folate supplements improves maternal and neonatal zinc status in a Peruvian population. American Journal of Clinical Nutrition 69, 1257–1263.CrossRefGoogle Scholar
Caulfield, LE, Zavaleta, N, Figueroa, A & Leon, Z (1999 b) Maternal zinc supplementation does not affect size at birth or pregnancy duration in Peru. Journal of Nutrition 129, 1563–1568.CrossRefGoogle ScholarPubMed
Chandra, K (1984) Excessive intake of zinc impairs immune response. Journal of the American Medical Association 252, 1443–1446.CrossRefGoogle Scholar
Christian, P & West, KP (1998) Interactions bewteen zinc and vitamin A: an update. American Journal of Clinical Nutrition 68, 435S-441S.CrossRefGoogle Scholar
Crea, A, Guérin, V, Ortega, F & Hartemann, P (1990) Zinc et systeme immunitaire. Annales Medicine Interne 141, 447–451.Google Scholar
Dowd, PS, Kelleher, J & Guillou, PJ (1986) T-lymphocyte subsets and interleukin-2 production in zinc-deficient rats. British Journal of Nutrition 55, 59–69.CrossRefGoogle ScholarPubMed
Driessen, C, Hirv, K, Rink, L & Kirchner, H (1994) Induction of cytokines by zinc in human peripheral blood mononuclear cells and separated monocytes. Lymphokine and Cytokine Research 13, 15–20.Google ScholarPubMed
Favier, A & Favier, M (1990) Conséquences des déficits en zinc durant la grossesse pour la mère et le nouveau-né. Revue francaise de Gynécologie et Obstétricie 85, 13–27.Google Scholar
Favier, AE (1992) The role of zinc in reproduction. Biological Trace Element Research 32, 363–382.CrossRefGoogle ScholarPubMed
Fischer, P, Giroux, A & L'Abbe, M (1984) Effect of zinc supplements on copper status in adult men. American Journal of Clinical Nutrition 40, 743–746.CrossRefGoogle Scholar
Goldenberg, RL, Tamura, T, Neggers, Y, Copper, RL, Johnston, KE, DuBard, MB & Hauth, JC (1995) The effect of zinc supplementation on pregnancy outcome. Journal of the American Medical Association 274, 463–468.CrossRefGoogle ScholarPubMed
Good, RA (1981) Nutrition and immunity. Journal of Clinical Immunology 1, 3–11.CrossRefGoogle ScholarPubMed
Hadden, JW (1992) Thymic endocrinology. International Journal of Immunopharmacology 14, 345–352.CrossRefGoogle ScholarPubMed
Jameson, S (1993) Zinc status in pregnancy: the effect of zinc therapy on perinatal mortality, prematurity, and placental ablation. Annals of the New York Academy of Science 678, 178–192.CrossRefGoogle Scholar
Keen, CL & Gershwin, ME (1990) Zinc deficiency and immune function. Annual Reviews of Nutrition 10, 415–431.CrossRefGoogle ScholarPubMed
Kirchner, H & Rühl, H (1970) Stimulation of human peripheral lymphocytes by Zn2+in vitro. Experimental Cell Research 61, 229–230.CrossRefGoogle Scholar
Kruse-Jarres, JD (1989) The significance of zinc for humoral and cellular immunity. Journal of Trace Elements and Electrolytes in Health and Disease 3, 1–8.Google ScholarPubMed
Merialdi, M, Caulfield, LE, Zavaleta, N, Figueroa, A & DiPietro, JA (1999) Adding zinc to prenatal iron and folate tablets improves fetal neurobehavioral development. American Journal of Obstetrics and Gynecology 180, 483–490.CrossRefGoogle ScholarPubMed
Mertz, W (1995) Risk assessment of essential trace elements: new approaches to assessing recommended dietary allowances and safety limits. Nutrition Review 53, 179–185.CrossRefGoogle ScholarPubMed
Mocchegiani, E, Santarelli, L, Muzziolo, M & Fabris, N (1995) Reversibility of the thymic involution and of age-related peripheral immune dysfunction by zinc supplementation in old mice. International Journal of Immunopharmacology 17, 703–718.CrossRefGoogle Scholar
National Research Council 1989 US Recommended Daily Allowances 10th edition. Washington, National Academy Press.Google Scholar
Neldner, KH & Hambidge, KM (1975) Zinc therapy in acrodermatitis enteropathica. New England Journal of Medicine 292, 879–882.CrossRefGoogle ScholarPubMed
Prasad, AS & Oberleas, BE (1970) Binding of zinc to amino acids and serum proteins in vitro. Journal of Laboratory and Clinical Medicine 76, 416–425.Google ScholarPubMed
Prasad, AS (1991) Discovery of human zinc deficiency and studies in an experimental human model. American Journal of Clinical Nutrition 53, 403–412.CrossRefGoogle Scholar
Prasad, AS (1995) Zinc: an overview. Nutrition 11, 93–99.Google ScholarPubMed
Salas, M & Kirchner, H (1987) Induction of interferon-γ in human leukocyte cultures stimulated by Zn2+. Clinical Immunology and Immunopathology 45, 139–142.CrossRefGoogle ScholarPubMed
Sandstead, HH (1995) Requirements and toxicity of essential trace elements illustrated by zinc and copper. American Journal of Clinical Nutrition 61, 621S-624S.CrossRefGoogle ScholarPubMed
Sazawal, S, Black, RE, Bhan, MK, Bhandari, N, Sinha, A & Jalla, S (1995) Zinc supplementation in young children with acute diarrhea in India. New England Journal of Medicine 333, 839–844.CrossRefGoogle ScholarPubMed
Shankar, AH & Prasad, AS (1998) Zinc and immune function: the biological basis of altered resistance to infection. American Journal of Clinical Nutrition 68, 447S-463S.CrossRefGoogle ScholarPubMed
Valdes-Ramos, R (1992) Zinc: a perinatal point of view. Progress in Food and Nutrition Science 16, 279–306.Google ScholarPubMed
Vallee, BL & Falchuk, KH (1993) The biochemical basis of zinc physiology. Physiological Reviews 73, 79–118.CrossRefGoogle ScholarPubMed
Vruwink, KG, Hurley, LS, Gershwin, ME & Keen, CL (1988) Gestational zinc deficiency amplifies the regulation of metallothionein induction in adult mice. Proceedings of the Society for Experimental Biology and Medicine 188, 30–34.CrossRefGoogle ScholarPubMed
Walsh, CT, Sandstead, HH, Prasad, AS, Newberne, PM & Fraker, PJ (1994) Zinc: health effects and research priorities for the 1990s. Environmental and health perspectives 102, 5–46.Google ScholarPubMed
Wellinghausen, N, Kirchner, H & Rink, L (1997 a) The immunobiology of zinc. Immunology Today 18, 519–521.CrossRefGoogle ScholarPubMed
Wellinghausen, N, Martin, M & Rink, L (1997 b) Zinc inhibits interleukin 1-dependent T-cell stimulation. European Journal of Immunology 27, 2529–2535.CrossRefGoogle ScholarPubMed