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The immune system: a target for functional foods?

Published online by Cambridge University Press:  09 March 2007

Philip C. Calder  and
Samantha Kew
Philip C. Calder*
Affiliation:
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Samantha Kew
Affiliation:
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
*
*Corresponding author: Dr P. C. Calder, fax +44 23 8059 4383, email [email protected]
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Abstract

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The immune system acts to protect the host from infectious agents that exist in the environment (bacteria, viruses, fungi, parasites) and from other noxious insults. The immune system is constantly active, acting to discriminate ‘non-self’ from ‘self’. The immune system has two functional divisions: the innate and the acquired. Both components involve various blood-borne factors (complement, antibodies, cytokines) and cells. A number of methodologies exist to assess aspects of immune function; many of these rely upon studying cells in culture ex vivo. There are large inter-individual variations in many immune functions even among the healthy. Genetics, age, gender, smoking habits, habitual levels of exercise, alcohol consumption, diet, stage in the female menstrual cycle, stress, history of infections and vaccinations, and early life experiences are likely to be important contributors to the observed variation. While it is clear that individuals with immune responses significantly below ‘normal’ are more susceptible to infectious agents and exhibit increased infectious morbidity and mortality, it is not clear how the variation in immune function among healthy individuals relates to variation in susceptibility to infection. Nutrient status is an important factor contributing to immune competence: undernutrition impairs the immune system, suppressing immune functions that are fundamental to host protection. Undernutrition leading to impairment of immune function can be due to insufficient intake of energy and macronutrients and/or due to deficiencies in specific micronutrients. Often these occur in combination. Nutrients that have been demonstrated (in either animal or human studies) to be required for the immune system to function efficiently include essential amino acids, the essential fatty acid linoleic acid, vitamin A, folic acid, vitamin B6, vitamin B12, vitamin C, vitamin E, Zn, Cu, Fe and Se. Practically all forms of immunity may be affected by deficiencies in one or more of these nutrients. Animal and human studies have demonstrated that adding the deficient nutrient back to the diet can restore immune function and resistance to infection. Among the nutrients studied most in this regard are vitamin E and Zn. Increasing intakes of some nutrients above habitual and recommended levels can enhance some aspects of immune function. However, excess amounts of some nutrients also impair immune function. There is increasing evidence that probiotic bacteria improve host immune function. The effect of enhancing immune function on host resistance to infection in healthy individuals is not clear.

Keywords

NutritionImmune functionLymphocyteMacrophageMonocyteCytokineInfection
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue S2 , November 2002 , pp. S165 - S176
Copyright
Copyright © The Nutrition Society 2002

References

Arvola, T, Laiho, K, Torkkeli, S, Mykkanen, H, Salminen, S, Maunula, L & Isolauri, E (1999) Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomised study. Pediatrics 104, L1–L4.CrossRefGoogle Scholar
Baehner, RL, Boxer, LA, Allen, JM & Davis, J (1977) Auto-oxidation as a basis for altered function by polymorphonuclear leukocytes. Blood 50, 327–335.Google Scholar
Bahl, R, Bhandari, N, Hambridge, KM & Bhan, MK (1988) Plasma zinc as a predictor of diarrhoeal and respiratory morbidity in children in an urban slum setting. American Journal of Clinical Nutrition 68, 414S–417S.CrossRefGoogle Scholar
Beach, RS, Gershwin, ME & Hurley, LS (1982) Gestational zinc deprivation in mice: persistence of immunodeficiency for three generations. Science 218, 469–471.CrossRefGoogle ScholarPubMed
Beck, FWJ, Prasad, AS, Kaplan, J, Fitzgeral, JT & Brewer, GJ (1997) Changes in cytokine production and T cell sub-populations in experimentally induced zinc deficient humans. American Journal of Physiology 272, E1002–E1007.Google Scholar
Bendich, A (1993) Vitamin E and human immune functions. In Nutrition and Immunology, pp. 217–228 [Klurfeld, DM, editor]. New York/London: Plenum Press.Google Scholar
Boxer, LA (1986) Regulation of phagocyte function by α-toco-pherol. Proceedings of the Nutrition Society 45, 333–344.CrossRefGoogle Scholar
Calder, PC & Jackson, AA (2000) Undernutrition, infection and immune function. Nutrition Research Reviews 13, 3–29.CrossRefGoogle ScholarPubMed
Calder, PC & Yaqoob, P (2000) The level of protein and type of fat in the diet of pregnant rats both affect lymphocyte function in the offspring. Nutrition Research 20, 995–1005.Google Scholar
Castillo-duran, C, Heresi, G, Fisberg, M & Uauy, R (1987) Controlled trial of zinc supplementation during recovery from malnutrition: effects on growth and immune function. American Journal of Clinical Nutrition 45, 602–608.Google Scholar
Chandra, RK (1984) Excessive intake of zinc impairs immune responses. Journal of the American Medical Association 252, 1443–1446.Google Scholar
Chandra, RK (1991) 1990 McCollum Award Lecture. Nutrition and immunity: lessons from the past and new insights into the future. American Journal of Clinical Nutrition 53, 1087–1101.CrossRefGoogle ScholarPubMed
Chandra, RK & Dayton, DH (1982) Trace element regulation of immunity and infection. Nutrition Research 2, 721–733.CrossRefGoogle Scholar
Chavance, M, Herbeth, B, Fournier, C, Janot, C & Vernhes, G (1989) Vitamin status, immunity and infections in an elderly population. European Journal of Clinical Nutrition 43, 827–835.Google Scholar
Chirico, G, Marconi, M, Colombo, A, Chiara, A, Rondini, G & Ugazio, A (1983) Deficiency of neutrophil phagocytosis in premature infants: effect of vitamin E supplementation. Acta Pediatrica Scandanavica 72, 521–524.CrossRefGoogle ScholarPubMed
Corwin, LM & Schloss, J (1980) Role of antioxidants on the stimulation of the mitogen response. Journal of Nutrition 110, 2497–2505.CrossRefGoogle Scholar
Cunningham-rundles, S (1998) Analytical methods for evaluation of immune response in nutrient intervention. Nutrition Reviews 56, S27–S37.CrossRefGoogle ScholarPubMed
Devaraj, S, Li, D & Jialal, I (1996) The effects of α-tocopherol supplementation on monocyte function. Journal of Clinical Investigation 98, 756–763.CrossRefGoogle ScholarPubMed
Failla, ML & Hopkins, RG (1998) Is low copper status immunosuppressive? Nutrition Reviews 56, S59–S64.CrossRefGoogle ScholarPubMed
Fraker, PJ, Gershwin, ME, Good, RA & Prasad, A (1986) Interrelationships between zinc and immune function. Federation Proceedings 45, 1474–1479.Google Scholar
Fraker, P & King, L (1998) Changes in regulation of lymphpoiesis and myelopoiesis in the zinc-deficient mouse. Nutrition Reviews 56, S65–S69.Google Scholar
Fraker, PJ, King, LE, Garvy, BA & Medina, CA (1993) The immunopathology of zinc deficiency in humans and rodents: a possible role for programmed cell death. In Nutrition and Immunology, pp. 267–283 [ Klurfeld, DM. editor]. New York/London: Plenum Press.CrossRefGoogle Scholar
Fukushima, Y, Kawata, Y, Hara, H, Terada, A &Mitsuoka, T (1998) Effect of probiotic formula on intestinal immunoglobulin A production in healthy children. International Journal of Food Microbiology 42, 39–44.CrossRefGoogle ScholarPubMed
Golden, MHN, Golden, BE, Harland, PSEG & Jackson, AA (1978) Zinc and immunocompetence in protein–energy malnutrition. Lancet i, 1226–1228.CrossRefGoogle Scholar
Golden, MHN, Jackson, AA & Golden, BE (1977) Effect of zinc on thymus of recently malnourished children. Lancet ii, 1057–1059.CrossRefGoogle Scholar
Goldin, BR (1998) Health benefits of probiotics British Journal of Nutrition 80, S203–S207.CrossRefGoogle ScholarPubMed
Gross, RL & Newberne, PM (1980) Role of nutrition in immunologic function. Physiological Reviews 60, 188–302.CrossRefGoogle ScholarPubMed
Han, SN & Meydani, SN (1999) Vitamin E and infectious disease in the aged. Proceedings of the Nutrition Society 58, 697–705.CrossRefGoogle Scholar
Han, SN, Wu, D, Smith, DE, Beharka, A,Wang, H, Bender, BS & Meydani, SN (1998) Vitamin E supplementation increases splenocyte IL-2 and IFN-γ production in old mice infected with influenza virus. FASEB Journal 12, A819.Google Scholar
Hayek, MG, Taylor, SF, Bender, BS, Han, SN, Meydani, M,Smith, DE, Eghtesada, S & Meydani, SN (1997) Vitamin E supplementation decreases lung virus titers in mice infected with influenza. Journal of Infectious Diseases 176, 273–276.CrossRefGoogle ScholarPubMed
Herias, MV, Hessle, C, Telemo, E, Midtvedt, T, Hanson, LA & Wold, AE (1999) Immunomodulatory effects of Lactobacillus plantarum colonizing the intestine of gnotobiotic rats. Clinical and Experimental Immunology 116, 283–290.CrossRefGoogle ScholarPubMed
Kuvibidila, S, Yu, L, Ode, D & Warrier, RP (1993) The immune response in protein–energy malnutrition and single nutrient deficiencies. In Nutrition and Immunology, pp. 121–155 [ Klurfeld, DM editor]. New York/London: Plenum Press.Google Scholar
Link-amster, H, Rochat, F, Saudan, KY, Mignot, O & Aeschlimann, JM (1994)Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunology and Medical Microbiology 10, 55–64.CrossRefGoogle ScholarPubMed
Lira, PI, Ashworth, A & Morris, SS (1998) Effect of zinc supplementation on the morbidity, immune function and growth of low birth weight full-term infants in northeast Brazil. American Journal of Clinical Nutrition 69, 418S–424S.CrossRefGoogle Scholar
Mcdade, TW, Beck, MA, Kuzawa, C & Adair, SS (2001) Prenatal undernutrition, postnatal environments, and antibody response to vaccination in adolescence. American Journal of Clinical Nutrition 74, 543–548.Google Scholar
Meydani, SN, Barklund, MP, Liu, S, Meydani, M, Miller, RA, Cannon, JG, Morrow, FD, Rocklin, R & Blumberg, JB (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. American Journal of Clinical Nutrition 52, 557–563.Google Scholar
Meydani, SN & Beharka, AA (1998) Recent developments in vitamin E and immune response. Nutrition Reviews 56, S49–S58.Google Scholar
Meydani, SN, Endres, S, Woods, MM, Goldin, BR, Soo, C, Morrill-labrode, A, Dinarello, C & Gorbach, SL (1991) Oral (n — 3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. Journal of Nutrition 121, 547–555.Google Scholar
Meydani, SN, Meydani, M, Blumberg, JB, Leka, LS, Siber, G, Loszewski, R, Thompson, C, Pedrosa, MC, Diamond, RD & Stollar, BD (1997) Vitamin E supplementation and in vivo immune response in healthy subjects. Journal of the American Medical Association 277, 1380–1386.Google Scholar
Meydani, SN, Meydani, M, Verdon, CP, Shapiro, AC, Blumberg, JB & Hayes, KC (1986) Vitamin E supplementation suppresses prostaglandin E2 synthesis and enhances the immune response in aged mice. Mechanisms of Ageing and Development 34, 191–201.Google Scholar
Meydani, SN, Yogeeswaran, G, Liu, S, Baskar, S & Meydani, M (1988) Fish oil and tocopherol-induced changes in natural killer cell-mediated cytotoxicity and PGE2 synthesis in old and young mice. Journal of Nutrition 118, 1245–1252.Google Scholar
Moore, SE, Cole, TJ, Poskitt, EME, Sonko, BJ, Whitehead, RG, Mcgregor, IA& Prentice, AM (1997) Season of birth predicts mortality in rural Gambia. Nature 338, 434.Google Scholar
Naidu, AS, Bidlack, WR & Clemens, RA (1999) Probiotic spectra of lactic acid bacteria (LAB). Critical Reviews in Food Science and Nutrition 38, 13–126.CrossRefGoogle Scholar
Prasad, JS (1980) Effect of vitamin E supplementation on leukocyte function. American Journal of Clinical Nutrition 33, 606–608.Google Scholar
Prohaska, JR & Failla, ML (1993) Copper and immunity. In Nutrition and Immunology, pp. 309–332 [ Klurfeld, DM. editor]. New York/London: Plenum Press.Google Scholar
Rayon, JI, Carver, JD, Wyble, LE, Wiener, D, Dickey, SS, Benford, VJ, Chen, LT & Lim, DV (1997) The fatty acid composition of maternal diet affects lung prostaglandin E2 levels and survival from Group B Streptococcal sepsis in neonatal rat pups. Journal of Nutrition 127, 1989–1992.CrossRefGoogle Scholar
Rosado, JL, Lopez, P, Munoz, E, Martinez, H & Allen, LH (1997) Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican pre-schoolers. American Journal of Clinical Nutrition 65, 13–19.CrossRefGoogle ScholarPubMed
Roy, SK, Tomkins, AM, Haider, R, Behra, RH, Akramuzzaman, SM, Mahalanabis, D & Fuchs, GJ (1999) Impact of zinc supplementation on subsequent growth and morbidity in Bangladeshi children with acute diarrhoea. European Journal of Clinical Nutrition 53, 529–534.Google Scholar
Schiffrin, EJ, Brassart, D, Servin, AL, Rochat, F & Donnet-hughes, A (1997) Immune modulation of blood leukocytes in humans by lactic acid bacteria: criteria for strain selection. American Journal of Clinical Nutrition 66, S515–S520.CrossRefGoogle ScholarPubMed
Scrimshaw, NS & Sangiovanni, JP (1997)Synergism of nutrition, infection and immunity: an overview. American Journal of Clinical Nutrition 66, 464S–477S.CrossRefGoogle ScholarPubMed
Shankar, AH & Prasad, AS (1998) Zinc and immune function: the biological basis of altered resistance to infection. American Journal of Clinical Nutrition 68, 447S–463S.CrossRefGoogle ScholarPubMed
Tapazoglou, E, Prasad, AS, Hill, G, Brewer, GJ & Kaplan, J (1985) Decreased natural killer cell activity in patients with zinc deficiency and sickle cell disease. Journal of Laboratory and Clinical Medicine 15, 19–22.Google Scholar
Thies, F, Miles, EA, Nebe-von-caron, G, Powell, JR, Hurst, TL, Newsholme, EA & Calder, PC (2001 a) Influence of dietary supplementation with long chain n — 3 or n — 6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids 36, 1183–1193.CrossRefGoogle ScholarPubMed
Thies, F, Nebe-von-caron, G, Powell, JR, Yaqoob, P, Newsholme, EA & Calder, PC (2001 b) Dietary supplementation with γ-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. Journal of Nutrition 131, 1918–1927.CrossRefGoogle ScholarPubMed
Vanderhoof, JA, Whitney, DB, Antonson, DL, Hanner, TL, Lupo, JV & Young, RJ (1999) Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. Journal of Pediatrics 135, 564–568.CrossRefGoogle ScholarPubMed
Vobecky, JS, Vobecky, J, Shapcott, D & Rola-pleszczynski, M (1984) Nutritional influences on humoral and cell-mediated immunity in healthy infants. Journal of the American College of Nutrition 3, 265.Google Scholar
Wang, Y, Huang, DS, Eskelson, CD & Watson, RR (1994) Long-term dietary vitamin E retards development of retro-virus-induced dysregulation in cytokine production. Clinical Immunology and Immunopathology 72, 70–75.CrossRefGoogle Scholar
Wellinghausen, N, Kirchner, H & Rink, L (1997) The immuno-biology of zinc. Immunology Today 18, 519–521.CrossRefGoogle Scholar
Yaqoob, P, Newsholme, EA & Calder, PC (1999) Comparison of cytokine production in cultures of whole human blood and purified mononuclear cells. Cytokine 11, 600–605.CrossRefGoogle ScholarPubMed
Yaqoob, P, Pala, HS, Cortina-borja, M, Newsholme, EA & Calder, PC (2000) Encapsulated fish oil enriched in α-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. European Journal of Clinical Investigation 30, 260–274.CrossRefGoogle Scholar
Yoon, H, Dubarry, M, Bouley, C, Meredith, C, Portier, A, Tome, D, Renevot, O, Blachon, JL, Dugas, B, Drewitt, P & Postaire, E (1999) New insights in the validation of systemic biomarkers for the evaluation of the immunoregulatory properties of milk fermented with yoghurt culture and Lactobacillus casei (Actimel (R)): a prospective trial. International Journal of Immunotherapy 15, 79–89.Google Scholar