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The hypotensive response to oral fat is comparable but slower compared with carbohydrate in healthy elderly subjects

Published online by Cambridge University Press:  08 March 2007

Renuka Visvanathan ,
Michael Horowitz  and
Ian Chapman
Renuka Visvanathan*
Affiliation:
Department of Medicine, University of Adelaide, Adelaide, South Australia Aged and Extended Care Service, The Queen Elizabeth Hospital, Woodville South, Adelaide, South Australia
Michael Horowitz
Affiliation:
Department of Medicine, University of Adelaide, Adelaide, South Australia
Ian Chapman
Affiliation:
Department of Medicine, University of Adelaide, Adelaide, South Australia
*
*corresponding author: Dr Renuka Visvanathan, fax 08 82228593, email [email protected]
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Abstract

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The objective of the present study was to determine the comparative hypotensive responses to drinks containing predominantly fat and carbohydrate (CHO) in healthy elderly subjects. Using a randomised, cross-over study, the participants, twelve elderly subjects, six of them female (72·2 (sd 5·7) years), were investigated. On three separate days, blood pressure (BP) and heart rate were measured following ingestion of 300ml drinks containing: (1) CHO (75g glucose and 93g Polyjoule (CHO polymer) providing 2732kJ (653kcal)); (2) 88% fat (cream blended with milk providing 2732kJ (653kcal)); (3) water. Systolic BP decreased following the CHO drink (P<0·001) and the high-fat drink (P<0·001) but not water; there was no difference in the magnitude of the decrease between the CHO drink and the drink containing fat (13·4v. 15·6mmHg). However, the onset of the fall was slower after the fat-containing drink (13·0v. 26·5min (P=0·01); area under the curve for 0–30min for CHO drink −6·5v. fat-containing drink 125·4 mmHg×min (P=0·043)). We conclude that ingestion of a high-fat drink results in a comparable fall in BP to a CHO drink although the onset is relatively slower. These observations may have implications for the management of postprandial hypotension.

Keywords

Postprandial hypotensionBlood pressureElderly
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 2 , February 2006 , pp. 340 - 345
Copyright
Copyright © The Nutrition Society 2006

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