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High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females

Published online by Cambridge University Press:  17 April 2007

Virpi E. Kemi ,
Merja U. M. Kärkkäinen  and
Christel J. E. Lamberg-Allardt
Virpi E. Kemi
Affiliation:
Calcium Research Unit, Department of Applied Chemistry and Microbiology, P.O. Box 66, University of Helsinki, FIN-00014 Helsinki, Finland
Merja U. M. Kärkkäinen
Affiliation:
Calcium Research Unit, Department of Applied Chemistry and Microbiology, P.O. Box 66, University of Helsinki, FIN-00014 Helsinki, Finland
Christel J. E. Lamberg-Allardt*
Affiliation:
Calcium Research Unit, Department of Applied Chemistry and Microbiology, P.O. Box 66, University of Helsinki, FIN-00014 Helsinki, Finland
*
*Corresponding author: Dr Christel Lamberg-Allardt, fax +358 9 19158269, email [email protected]
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Abstract

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Ca and P are both essential nutrients for bone and are known to affect one of the most important regulators of bone metabolism, parathyroid hormone (PTH). Too ample a P intake, typical of Western diets, could be deleterious to bone through the increased PTH secretion. Few controlled dose–response studies are available on the effects of high P intake in man. We studied the short-term effects of four P doses on Ca and bone metabolism in fourteen healthy women, 20–28 years of age, who were randomized to four controlled study days; thus each study subject served as her own control. P supplement doses of 0 (placebo), 250, 750 or 1500mg were taken, divided into three doses during the study day. The meals served were exactly the same during each study day and provided 495mg P and 250mg Ca. The P doses affected the serum PTH (S-PTH) in a dose-dependent manner (P=0·0005). There was a decrease in serum ionized Ca concentration only in the highest P dose (P=0·004). The marker of bone formation, bone-specific alkaline phosphatase, decreased (P=0·05) and the bone resorption marker, N-terminal telopeptide of collagen type I, increased in response to the P doses (P=0·05). This controlled dose–response study showed that P has a dose-dependent effect on S-PTH and increases PTH secretion significantly when Ca intake is low. Acutely high P intake adversely affects bone metabolism by decreasing bone formation and increasing bone resorption, as indicated by the bone metabolism markers.

Keywords

Parathyroid hormoneBone metabolismPhosphorus intakeDose–response study
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 3 , September 2006 , pp. 545 - 552
Copyright
Copyright © The Nutrition Society 2006

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