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Hepatic lipogenesis in young rats given proteins of different quality

Published online by Cambridge University Press:  09 March 2007

G. R. Herzberg  and
Minda Rogerson
G. R. Herzberg
Affiliation:
Department of Biochemistry, Memorial University of Newfoundland, St John's, Newfoundland A1B 3X9, Canada
Minda Rogerson
Affiliation:
Department of Biochemistry, Memorial University of Newfoundland, St John's, Newfoundland A1B 3X9, Canada
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Abstract

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1. The effect of feeding casein, lactalbumin, soya-bean protein, gluten or gelatin on hepatic lipogenesis and the levels of hepatic fatty acid synthetase (FAS), glucose-6-phosphate dehydrogenase (EC 1. 1. 1.49; G6PD), malic enzyme (EC 1. 1. 1.40; ME) ATP-citrate lyase (EC 4. 1. 3. 8; CL), acetyl CoA carboxylase (EC 6.4.1.2; ACCx) and glucokinase (EC 2. 7. 1. 2; GK) was examined in young growing rats.

2. The total activities of ACCx, FAS, CL, GK, G6PD, GK, ME and fatty acid synthesis in vivo were positively correlated with protein quality.

3. The specific activities of ACCx, FAS, CL, G6PD and fatty acid synthesis in vivo were positively correlated with protein quality.

4. The specific activities of GK and ME were unrelated to protein quality.

5. The results demonstrate a dissociation between ME and hepatic lipogenesis and suggest a role for the NADPH generated by ME which is not related to the needs of fatty acid synthesis.

Type
Research Article
Information
British Journal of Nutrition , Volume 52 , Issue 1 , July 1984 , pp. 131 - 137
Copyright
Copyright © The Nutrition Society 1984

References

REFERENCES

Frenkel, R. (1975).Current Topics in Cell Regulation 9, 157–181.CrossRefGoogle Scholar
Frenkel, R., Stark, M. J. & Stafford, J. (1972). Biochemical and Biophysical Research Communications 49, 1684–1689.CrossRefGoogle Scholar
Gibson, D. M. & Hubbard, D. D. (1960). Biochemical and Biophysical Research Communications 3, 531–535.CrossRefGoogle Scholar
Gibson, D. M., Lyons, R. T., Scott, D. F. & Muto, Y. (1972). Advances in Enzyme Regulation 10, 187–204.CrossRefGoogle Scholar
Goa, J. (1953). Scandinavian Journal of Clinical Laboratory Investigation 5, 218–222.CrossRefGoogle Scholar
Gove, C. D. & Hems, D. A. (1978). Biochemical Journal 170, 1–8.CrossRefGoogle Scholar
Herzberg, G. R. (1983). Advances in Nutrition Research 5, 221–253.CrossRefGoogle Scholar
Herzberg, G. R. & Rogerson, M. (1981). British Journal of Nutrition 45, 529–538.CrossRefGoogle Scholar
Herzberg, G. R. & Rogerson, M. (1982). Canadian Journal of Physiology and Pharmacology 60, 912–919.CrossRefGoogle Scholar
Hill, R., Webster, W. W., Linazasoro, J. M. & Chaikoff, I. L. (1960). Journal of Lipid Research 1, 150–153.CrossRefGoogle Scholar
Lohr, G. W. & Waller, H. O. (1971). In methods of Enzymatic Analysis, vol.2, pp. 636–643 [Bergmeyer, H. V., editor]. New york: Academic press.Google Scholar
Lowenstein, J. M. (1971).Journal of Biological chemistry 246, 629–632.CrossRefGoogle Scholar
Peret, U., Chanes, M., Cota, J. & Macaire, I. (1975). Journal of Nutrition 105, 1525–1534.CrossRefGoogle Scholar
Pilkis, S. J. (1975). In Methods in Enzymology, vol. 42, pp. 31–39 [ Wood, W. A., editor]. New york: Academic press.Google Scholar
Romsos, D. R. & Leveille, G. A. (1974). Advances in Lipid Research 12, 97–146.CrossRefGoogle Scholar
Srere, P. A. (1959). Journal of Biological Chemistry 234, 2544–2547.CrossRefGoogle Scholar
Stark, M. J. & Frenkel, R. (1974). Life Sciences 14, 1563–1575.CrossRefGoogle Scholar
Stark, M. J., Thompson, B. & Frenkel, R. (1975). Archives of Biochemistry and Biophysics 166, 174–182.CrossRefGoogle Scholar
Vaughan, D. A. & Winders, R. L. (1964). American Journal of Physiology 206, 1081–1084.CrossRefGoogle Scholar
Yeh, Y. Y. & Leveille, G. A. (1969). Journal of Nutrition 98, 356–366.CrossRefGoogle Scholar
Yeh, Y. Y., Leveille, G. A. & Wiley, J. H. (1970). Journal of Nutrition 100, 917–924.CrossRefGoogle Scholar