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Haematological response to iron supplementation is reduced in children with asymptomatic Helicobacter pylori infection

Published online by Cambridge University Press:  08 March 2007

Dilip Mahalanabis ,
M. Aminul Islam ,
Saijuddin Shaikh ,
Monilal Chakrabarty ,
Anura V. Kurpad ,
Swagata Mukherjee ,
Bandana Sen ,
M. Abu Khaled  and
Sten H. Vermund
Dilip Mahalanabis*
Affiliation:
Society for Applied Studies, 108 Maniktala Main Road, Flat-3/21, Kolkata – 700 054, India
M. Aminul Islam
Affiliation:
University of Alabama at Birmingham, Birmingham, Alabama, USA
Saijuddin Shaikh
Affiliation:
Society for Applied Studies, 108 Maniktala Main Road, Flat-3/21, Kolkata – 700 054, India
Monilal Chakrabarty
Affiliation:
Kothari Medical Research Centre, Kolkata, India
Anura V. Kurpad
Affiliation:
St. Johns Medical College, Bangalore, India
Swagata Mukherjee
Affiliation:
Infectious Diseases Hospital, Kolkata, India
Bandana Sen
Affiliation:
Society for Applied Studies, 108 Maniktala Main Road, Flat-3/21, Kolkata – 700 054, India
M. Abu Khaled
Affiliation:
University of Alabama at Birmingham, Birmingham, Alabama, USA
Sten H. Vermund
Affiliation:
University of Alabama at Birmingham, Birmingham, Alabama, USA
*
*Corresponding author: Dr Dilip Mahalanabis, fax +91 33 2337 6290, email [email protected]
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Abstract

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We evaluated the adverse effect of asymptomatic Helicobacter pylori infection in children on the response to Fe supplementation. One hundred and sixty-nine children aged 1–10 years from the urban poor community underwent a [13C]urea breath test for H. pylori and haematological tests at admission and after 8 weeks. Both H. pylori-positive and -negative children were randomly assigned to receive ferrous fumarate syrup (20 mg elemental Fe twice daily) or placebo for 8 weeks and a single dose of vitamin A (33,000μg). Admission findings were compared between H. pylori-positive and -negative children. Response to Fe was compared between Fe-supplemented H. pylori-positive and -negative children. Seventy-nine per cent of the children were aged 1–5 years and half of them were boys. In eighty-five H. pylori-positive and eighty-four H. pylori-negative children, the differences in mean Hb (112 (sd 12·6) v. 113 (sd 12·0) g/l), haematocrit (34 (sd 3·5) v. 35 (sd 3·2) %) and ferritin (23·8 v. 21·0 μg/l) were similar. After 8 weeks of Fe supplementation, mean Hb was 5·3 g/l more (95 % CI 1·59, 9·0) and haematocrit was 1·4 % more (95 % CI 0·2, 2·6) in H. pylori-negative (n 44) compared with H. pylori-positive (n 42) children. Mean ferritin was similar at admission and improved in both H. pylori-positive and -negative children. Asymptomatic H. pylori infection was not associated with higher rates of anaemia or Fe deficiency in children, but had a significant adverse effect on response to Fe therapy. However, this result is based on exploratory analysis and needs confirmation.

Keywords

Helicobacter pyloriAnaemiaChildrenIron supplementationIron status
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 6 , December 2005 , pp. 969 - 975
Copyright
Copyright © The Nutrition Society 2005

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