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Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins

Published online by Cambridge University Press:  09 March 2007

I. Stuart Wood  and
Paul Trayhurn
I. Stuart Wood*
Affiliation:
Liverpool Centre for Nutritional Genomics, Neuroendocrine & Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Liverpool L69 3GA, UK
Paul Trayhurn
Affiliation:
Liverpool Centre for Nutritional Genomics, Neuroendocrine & Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Liverpool L69 3GA, UK
*
*Corresponding author: Dr I. S. Wood, fax +44 151 706 5802, email [email protected]
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Abstract

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The number of known glucose transporters has expanded considerably over the past 2 years. At least three, and up to six, Na+-dependent glucose transporters (SGLT1–SGLT6; gene name SLC5A) have been identified. Similarly, thirteen members of the family of facilitative sugar transporters (GLUT1–GLUT12 and HMIT; gene name SLC2A) are now recognised. These various transporters exhibit different substrate specificities, kinetic properties and tissue expression profiles. The number of distinct gene products, together with the presence of several different transporters in certain tissues and cells (for example, GLUT1, GLUT4, GLUT5, GLUT8, GLUT12 and HMIT in white adipose tissue), indicates that glucose delivery into cells is a process of considerable complexity.

Keywords

Glucose transporter proteinsDiabetes mellitusAdipose tissueMuscleSugar transport
Type
Horizons in Nutritional Science
Information
British Journal of Nutrition , Volume 89 , Issue 1 , January 2003 , pp. 3 - 9
Copyright
Copyright © The Nutrition Society 2003

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