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Glucose tolerance and insulin sensitivity in malnourished children

Published online by Cambridge University Press:  09 March 2007

G. A. O. Alleyne ,
P. M. Trust ,
H. Flores  and
H. Robinson
G. A. O. Alleyne
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, WI
P. M. Trust
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, WI
H. Flores
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, WI
H. Robinson
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, WI
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Abstract

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1. In malnourished, compared with recovered children, fasting blood glucose concentrations were low and there was impaired peripheral glycolysis as shown by a failure of blood lactate to rise after glucose was injected intravenously.

2. Homogenates of muscle biopsies from malnourished and recovered children produced equal amounts of lactate when incubated anaerobically with various substrates, but when compared with homogenates of biopsies from normal children the pattern suggested an impairment of glycolysis.

3. The rate of glucose disappearance after intravenous glucose was slow in the malnourished child and there was possibly diminished sensitivity to exogenous insulin.

4. Isocaloric diets relatively high or low in fat were fed to children who had recovered from malnutrition. Glucose tolerance, insulin sensitivity, fasting plasma insulin and insulin response to intravenous glucose were all the same in children on either diet.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 27 , Issue 3 , May 1972 , pp. 585 - 592
Copyright
Copyright © The Nutrition Society 1972

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