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Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children

Published online by Cambridge University Press:  08 March 2007

Pablo Sanjurjo ,
Luis AldámizEchevarría ,
Carmen Prado ,
Isabel Azcona ,
Javier Elorz ,
José A. Prieto ,
José I. Ruiz  and
Juan Rodríguez-Soriano
Pablo Sanjurjo*
Affiliation:
Hospital de Cru ces and Basque University School of Medicine, Division of Metabolism, Bilbao, Spain
Luis AldámizEchevarría
Affiliation:
Hospital de Cru ces and Basque University School of Medicine, Division of Metabolism, Bilbao, Spain
Carmen Prado
Affiliation:
Hospital de Cru ces and Basque University School of Medicine, Division of Metabolism, Bilbao, Spain
Isabel Azcona
Affiliation:
Hospital de Cruces and Basque University School of Medicine, Division of Pediatric Surgery, Department of Pediatrics, Bilbao, Spain
Javier Elorz
Affiliation:
Hospital de Cru ces and Basque University School of Medicine, Division of Metabolism, Bilbao, Spain
José A. Prieto
Affiliation:
Hospital de Cru ces and Basque University School of Medicine, Division of Metabolism, Bilbao, Spain
José I. Ruiz
Affiliation:
Basque University School of Medicine, Department of Physiology, Bilbao, Spain
Juan Rodríguez-Soriano
Affiliation:
Hospital de Cru ces and Basque University School of Medicine, Division of Metabolism, Bilbao, Spain
*
*Corresponding author: Dr Pablo Sanjurjo, fax +34 946006044, email [email protected]
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Abstract

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There is a relationship between the fatty acid profile in skeletal muscle phospholipids and peripheral resistance to insulin in adults, but similar data have not been reported in infancy and childhood. The objective of this study was to investigate the fatty acid composition of skeletal muscle and adipose tissue across the paediatric age range. The fatty acid profile of skeletal muscle phospholipids and adipose tissue triacylglycerols was analysed in ninety-three healthy Spanish infants and children distributed into four groups: group 1 (0 to <2 years, n 10); group 2 (2 to <5 years, n 41); group 3 (5 to <10 years, n 24); group 4 (10 to 15 years, n 18). In skeletal muscle phospholipids, oleic acid (18: 1n-9cis) content decreased significantly whereas that of linoleic (18: 2n-6) acid increased significantly with age (P for trend <0·01). In adipose tissue, the contents of triacylglycerol and linoleic acid increased significantly across the paediatric age range (P for trend <0·01), whereas dihomo-γ-linolenic (20: 3n-6) and arachidonic (20: 4n-6) showed significant differences between groups. The variations in fatty acid composition observed with age indicated an imbalance in dietary n-3/n-6 long-chain PUFA.

Keywords

Adipose tissueFatty acid compositionInsulin resistanceSkeletal muscleChildren
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 1 , January 2006 , pp. 168 - 173
Copyright
Copyright © The Nutrition Society 2006

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