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Fatty acid composition of platelet phospholipids in non-insulin-dependent diabetics randomized for dietary advice

Published online by Cambridge University Press:  09 March 2007

I. Lopez-Espinoza ,
J. Howard-Williams ,
J. I. Mann ,
R. D. Carter  and
T. D. R. Hockaday
I. Lopez-Espinoza
Affiliation:
Sheikh Rashid Diabetes Unit, Radclifle Infirmary, Oxford OX2 6HE
J. Howard-Williams
Affiliation:
The Eye Hospital, Walton Street, Oxford OX2 6HE
J. I. Mann
Affiliation:
Diabetes Research Laboratories, Radcliffe Infirmary, Oxford OX2 6HE
R. D. Carter
Affiliation:
Diabetes Research Laboratories, Radcliffe Infirmary, Oxford OX2 6HE
T. D. R. Hockaday
Affiliation:
Sheikh Rashid Diabetes Unit, Radclifle Infirmary, Oxford OX2 6HE
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Abstract

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1. Two groups of patients with non-insulin-dependent diabetes mellitus (NIDDM), with dietary advice randomized between a low-carbohydrate (LC) diet and a modified-fat (MF) diet, were followed to determine the effect of diet on phospholipid fatty acid composition of platelets and on development of retinopathy in the 7 years following diagnosis. There was a tendency for retinopathy to occur more frequently in those randomiEd to the LC diet. This difference was not statistically significant, and fatty acid composition of platelets did not differ significantly in those with and without retinopathy.

2. Linoleic acid values from platelet phospholipid fatty acids were significantly higher in NIDDM on an MF diet compared with an LC diet.

3. There was no difference between the two dietary subgroups with respect to platelet arachidonic acid, but this was lower in the whole diabetic population when compared with non-diabetics.

4. The arachidonic acid values correlated with neither glycosylated haemoglobin nor mean glycaemia.

5. Significant correlation between the fatty acid values for platelets and plasma cholesterol esters was found only for 16:0.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 52 , Issue 1 , July 1984 , pp. 41 - 47
Copyright
Copyright © The Nutrition Society 1984

References

Burstein, M., Scholnick, H. R. & Morfin, R. (1970). Journal of Lipid Research 11, 583–595.CrossRefGoogle Scholar
Dyerberg, J. & Bang, H. O. (1979). Lancet i, 433–435.CrossRefGoogle Scholar
Fleischman, A. I., Bierembaum, M. L., Justice, D., Stier, A., Sullivan, A. & Fleischman, M. (1975). American Journal of Clinical Nutrition 28, 601–605.CrossRefGoogle Scholar
Gryglewski, R. J. (1980). CRC Critical Reviews in Biochemistry 7, 291–338.CrossRefGoogle Scholar
Hockaday, T. D. R., Hockaday, J. M., Mann, J. I. & Turner, R. C. (1978). British Journal of Nutrition 39, 357–362.CrossRefGoogle Scholar
Houtsmuller, A. J., Zahn, K. J. & Henker, H. E. (1979). Documenta Ophthalmologica 48, 363–371.CrossRefGoogle Scholar
Howard-Williams, J., Patel, P., Jelfs, R., Carter, R. D., Awdry, P., Bron, A., Mann, J. I. & Hockaday, T. D. R. (1984). British Journal of Ophthalmology (In the Press).Google Scholar
Huang, T. C., Chen, C. P., Wefler, V. & Raftery, A. (1961). Analytical Chemistry 33, 1405–1407.Google Scholar
Jeppson, J. O. & Berglund, S. (1972). Clinica Chimica Acta 40, 153–158.Google Scholar
Jones, D. B., Carter, R. D., Haitas, B. & Mann, J. I. (1983). British Medical Journal 286, 173–175.CrossRefGoogle Scholar
Kloeze, J. (1967). In Prostaglandins: proceedings of 2nd nobel symposium, pp. 241–250. [Bergstrom, S. and Samuelsson, B., editors]. New york: Interscience.Google Scholar
Mathias, M. M., Fine, K., Lipinski, B. & Dupont, J. (1978). Prostaglandins 15, 706.Google Scholar
Moore, R. A., Oppert, S., Eaton, P. & Mann, J. I. (1977). Clinical Endocrinology 7, 143–149.CrossRefGoogle Scholar
Nordoy, A. & Rodset, M. (1971). Acta Medica Scandinavica 190, 27–34.Google Scholar
Ononongba, I. C. & Lewis, B. (1976). Clinica Chimica Acta 71, 397–402.Google Scholar
Paul, A. A. & Southgate, D. A. T. (1978). McCance and widdowson's The Composition of Foods, pp. 293–300. London: H.M. Stationery Office.Google Scholar
Sagel, J., Colwell, J. A., Crook, L. & Laimins, M. (1975). Annals of Internal Medicine 82, 733–738.CrossRefGoogle Scholar
Sanders, T. A., Vickers, M. & Haines, A. P. (1981). Clinical Science 61, 317–324.CrossRefGoogle Scholar
Seyberth, H. W., Oelz, O., & Kennedy, T. (1975). Clinical Pharmacology and Therapeutics 18, 521–529.CrossRefGoogle Scholar
Siess, W., Scherer, B., Bohlig, B., Roth, P., Kurzmann, I. & Weker, P. C. (1980). Lancet i, 441–444.CrossRefGoogle Scholar
Simpson, R. W., Carter, R. D., Moore, R. A. & Penfold, W. A. F. (1980). Diabetologia 18, 35–40.Google Scholar
Stone, D. B. & Connor, W. E. (1963). Diabetes 12, 127–131.CrossRefGoogle Scholar
Ylikorkala, O., Kaila, J. & Viinika, L. (1981). British Medical Journal 283, 1148–1150.Google Scholar