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Fatty acid composition of nuts – implications for cardiovascular health

Published online by Cambridge University Press:  19 April 2007

Emilio Ros  and
José Mataix
Emilio Ros*
Affiliation:
Unitat de Lípids, Sevei d'Endocrinologia i Nutrició, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain
José Mataix
Affiliation:
Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Granada, Granada, Spain
*
*Corresponding author: Emilio Ros, MD, fax +4 93 4537829, email [email protected]
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Abstract

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It is well established that, due to their high content of saturated fatty acids (SFA), the intake of meat and meat products is strongly associated with elevated blood cholesterol concentrations and an increased risk of hypertension, diabetes and cardiovascular diseases. Conversely, the intake of foods rich in unsaturated fatty acids, such as those contained in most vegetable fats and oils and oily fish, is associated with improved lipid profiles, a lower potency of intermediate biomarkers of atherosclerosis and lesser incidence of cardiovascular diseases. There are persuasive evidences that dietary substitution of monounsaturated fatty acids (MUFA) or n-6 polyunsaturated fatty acids (PUFA) for SFA lowers blood cholesterol and may have beneficial effects on inflammation, thrombosis, and vascular reactivity. MUFA may have an advantage over PUFA because enrichment of lipoprotein lipids with MUFA increases their resistance to oxidation. Marine n-3 PUFA have a number of anti-atherosclerotic effects, including anti-arrhythmic properties and, at relatively high doses, reduce serum triglycerides. These effects appear to be shared in part by vegetable n-3 PUFA. Nuts are natural foods rich in unsaturated fatty acids; most nuts contain substantial amounts of MUFA, while walnuts are especially rich in both n-6 and n-3 PUFA. Healthy fats in nuts contribute to the beneficial effects of frequent nut intake observed in epidemiological studies (prevention of coronary heart disease, diabetes, and sudden death) and in short-term feeding trials (cholesterol lowering, LDL resistance to oxidation, and improved endothelial function).

Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Supplement S2 , November 2006 , pp. S29 - S35
Copyright
Copyright © The Nutrition Society 2006

References

Albert, CM, Oh, K, Whang, W, Manson, JAE, Chae, CU, Stampfer, MJ, Willett, WC& Hu, FB (2005) Dietary α-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. Circulation 112, 3232–3238.CrossRefGoogle ScholarPubMed
lonso, A, Ruiz-Gutierrez, V & Martínez-González, MA (2006) Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidence. Publ Health Nutr 9, 251–257.Google Scholar
scherio, A, Katan, MB, Zock, PL, Stampfer, MJ & Willett, WC (1999) Trans fatty acids and coronary heart disease. N Engl J Med 340, 1994–1998.CrossRefGoogle Scholar
lomhoff, R, Carlsen, MH, Frost, Anderson L & Jacobs, DR (2006) Health benefits of nuts: potential role of antioxidants. Br J Nutr 96, suppl. 2, S52–S60.CrossRefGoogle Scholar
onetti, PO, Lerman, LO & Lerman, A (2003) Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23, 168–175.CrossRefGoogle Scholar
Brown, AA & Hu, FB (2001) Dietary modulation of endothelial function: implications for cardiovascular disease. Am J Clin Nutr 73, 673–686.CrossRefGoogle ScholarPubMed
Calder, PC (2002) Dietary modification of inflammation with lipids. Proc Nutr Soc 61, 345–358.CrossRefGoogle Scholar
Calder, PC (2004) n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci 107, 1–11.CrossRefGoogle ScholarPubMed
Clarke, SD (2004) The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr Opin Lipidol 15, 13–18.CrossRefGoogle ScholarPubMed
Clarke, R, Frost, C, Collins, R, Appleby, P & Peto, R (1997) Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. Br Med J 314, 112–117.CrossRefGoogle ScholarPubMed
Connors, WE, Connors, SL, Katan, MB, Grundy, SM, & Willett, WC (1997) Clinical debate. Should a low-fat, high-carbohydrate diet be recommended for everyone?. N Engl J Med 337, 562–567.Google Scholar
Davis, P, Valacchi, G, Pagnin, E, Shao, Q, Gross, HB, Calo, L & Yokoyamaz, W (2006) Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high-fat, atherogenic diet. J Nutr 136, 428–432.CrossRefGoogle ScholarPubMed
De Caterina, R, Liao, JK & Libby, P (2000) Fatty acid modulation of endothelial activation. Am J Clin Nutr 71, 213S–223S.CrossRefGoogle ScholarPubMed
De Koning, EJP & Rabelink, TJ (2002) Endothelial function in the postprandial state. Atherosclerosis Suppl 3, 11–16.CrossRefGoogle Scholar
De Lorgeril, M, Salen, P, Martin, JL, Monjaud, I, Delaye, J & Mamelle, N (1999) Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction. Circulation 99, 779–785.CrossRefGoogle ScholarPubMed
Djoussé, L, Hunt, SC, Arnett, DK, Province, MA, Eckfeldt, JH & Ellison, RC (2003) Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr 78, 1098–1102.CrossRefGoogle ScholarPubMed
Exler, J & Weihrauch, JL (1986) Provisional table on the content of omega-3 fatty acids and other fat components in selected foods. Washington, DC: US Department of Agriculture (Publication HNIS/PT-103).Google Scholar
Franz, MJ, Bantle, JP, Beebe, CA, Brunzell, JD, Chiasson, JL, Garg, A, Holzmeister, LA, Hoogwerf, B, Mayer-Davis, E, Mooradian, AD, Purnell, JQ & Wheeler, M; American Diabetes Association (2004) Nutrition principles and recommendations in diabetes. Diabetes Care 27, S36–S46.Google ScholarPubMed
Fuentes, F, López-Miranda, J, Sánchez, E, et al. (2001) Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann Intern Med 134, 1115–1119.CrossRefGoogle ScholarPubMed
Gardner, CD & Kraemer, HC (1995) Monounsaturated versus polyunsaturated dietary fat and serum lipids. Arterioscler Thromb Vasc Biol 15, 1917–1927.CrossRefGoogle ScholarPubMed
Geleijnse, JM, Giltay, EJ, Grobbee, DE, Donders, ART & Kok, FJ (2002) Blood pressure response to fish oil supplementation: meta-regression analysis of randomized trials. J Hypertens 20, 1493–1499.CrossRefGoogle Scholar
Griel, AE & Kris-Etherton, PM (2006) Tree Nuts and the Lipid Profile: A Review of Clinical Studies. Br J Nutr 96, S68–S78.CrossRefGoogle ScholarPubMed
Griffin, BA (2001) The effect of n-3 fatty acids on low density lipoprotein subfractions. Lipids 36, Suppl, S91–S97.CrossRefGoogle ScholarPubMed
Harris, WS (1997) n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 66, 1645S–1654S.CrossRefGoogle Scholar
Harris, WS (2005) Alpha-linolenic acid. A gift from the land?. Circulation 111, 2872–2874.CrossRefGoogle ScholarPubMed
Heller, A, Koch, T, Schmeck, J & van Ackern, K (1998) Lipid mediators in inflammatory disorders. Drugs 55, 487–496.CrossRefGoogle ScholarPubMed
Hermansen, K (2000) Diet, blood pressure and hypertension. Br J Nutr 83, S113–S119.CrossRefGoogle ScholarPubMed
Hooper, L, Summerbell, CD, Higgins, JP, Thompson, RL, Capps, NE, Smith, GD, Riemersma, RA & Ebrhim, S (2001) Dietary fat intake and prevention of cardiovascular disease: a systematic review. Br Med J 322, 757–763.CrossRefGoogle Scholar
Hu, FB & Willett, WC (2002) Optimal diets for prevention of coronary heart disease. JAMA 288, 2569–2578.CrossRefGoogle ScholarPubMed
Hu, FB, Manson, JE & Willett, WC (2001) Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr 20, 5–19.CrossRefGoogle ScholarPubMed
Hyson, DA, Schneeman, BO & Davis, PA (2002) Almonds and almond oil have similar effects on plasma lipids and LDL oxidation in healthy men and women. J Nutr 132, 703–707.CrossRefGoogle ScholarPubMed
Iwamoto, M, Imaizumi, K, Sato, M, Hirooka, Y, Sakai, K, Takeshita, A & Kono, M (2002) Serum lipid profiles in Japanese women and men during consumption of walnuts. Eur J Clin Nutr 56, 629–637.CrossRefGoogle ScholarPubMed
Jaceldo-Siegl, K, Sabaté, J, Rajaram, S & Fraser, GE (2004) Long-term almond supplementation without advice on food replacement induces favourable nutrient modifications to the habitual diets of free-living individuals. Br J Nutr 92, 533–540.CrossRefGoogle Scholar
Jiang, R, Manson, JE, Stampfer, MJ, Liu, S, Willett, WC & Hu, FB (2002) Nut and peanut butter consumption and risk of type 2 diabetes in women. JAMA 288, 2554–2560.CrossRefGoogle ScholarPubMed
Katan, MB & Zock, PL (1995) Trans fatty acids and their effects on lipoproteins in humans. Annu Rev Nutr 15, 473–493.CrossRefGoogle ScholarPubMed
Kelly, JH & Sabaté, J (2006) Nuts and Coronary Heart Disease: an epidemiological perspective. Br J Nutr 96, suppl. 2, S61–S67.CrossRefGoogle ScholarPubMed
Key, TJ, Allen, NE, Spencer, EA & Travis, RC (2002) The effect of diet on risk of cancer. Lancet 360, 861–868.CrossRefGoogle ScholarPubMed
Keys, A (1980) Seven Countries: a Multivariate Analysis of Death and Coronary Heart Disease. Cambridge, MA: Harvard University Press.CrossRefGoogle Scholar
Kirkmeyer, SV & Mattes, RD (2000) Effects of food attributes on hunger and food intake. Int J Obes Relat Metab Disord 24, 1167–1175.CrossRefGoogle ScholarPubMed
Kris-Etherton, P, Daniels, SR, Eckel, RH, et al. (2001) Summary of the Scientific Conference on Dietary Fatty Acids and Cardiovascular Health. Conference Summary from the Nutrition Committee of the American Heart Association. Circulation 103, 1034–1039.CrossRefGoogle ScholarPubMed
Kris-Etherton, PM. AHA Science Advisory (1999) Monounsaturated fatty acids and risk of cardiovascular disease. Circulation 100, 1253–1258.CrossRefGoogle ScholarPubMed
Leaf, A, Kang, JX, Xiao, YF & Billman, GE (2003) Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation 107, 2646–2652.CrossRefGoogle ScholarPubMed
Manco, M, Calvani, M & Mingrone, G (2004) Effects of dietary fatty acids on insulin sensitivity and secretion. Diabetes Obes Metab 6, 402–413.CrossRefGoogle ScholarPubMed
Mann, JI (2002) Diet and risk of coronary heart disease and type 2 diabetes. Lancet 360, 783–789.CrossRefGoogle ScholarPubMed
Mensink, RP & Katan, MB (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 12, 911–919.CrossRefGoogle ScholarPubMed
Mensink, RP, Zock, PL, Kester, AD & Katan, MB (2003) Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 77, 1146–1155.CrossRefGoogle ScholarPubMed
Moncada, S & Higgs, A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329, 2002–2012.Google ScholarPubMed
Mukkudem-Petersen, J, Oosthuizen, W & Jerling, JC (2005) A systematic review of the effects of nuts on blood lipid profiles in humans. J Nutr 135, 2082–2089.CrossRefGoogle Scholar
Muñoz, S, Merlos, M, Zambón, D, Rodríguez, C, Sabaté, J, Ros, E & Laguna, JC (2001) A walnut-enriched diet increases the association of LDL from hypercholesterolemic men to human hepatoma HEPG2 cells. J Lipid Res 42, 2069–2076.CrossRefGoogle Scholar
Parks, EJ & Hellerstein, MK (2000) Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am J Clin Nutr 71, 412–433.CrossRefGoogle ScholarPubMed
Parthasarathy, S, Khoo, JC, Miller, E, Barnett, J, Witztum, JL & Steinberg, D (1990) Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis. Proc Natl Acad Sci USA 87, 3894–3898.CrossRefGoogle Scholar
Pérez-Jiménez, F, López-Miranda, J & Mata, P (2002) Protective effect of dietary monounsaturated fat on arteriosclerosis: beyond cholesterol. Atherosclerosis 163, 385–398.CrossRefGoogle ScholarPubMed
Rallidis, LS, Paschos, P, Papaioannou, ML, Liakos, GK, Panagiotakos, DB, Anastasiadis, G & Zampelas, A (2004) The effect of diet enriched with alpha-linolenic acid on soluble cellular adhesion molecules in dyslipidaemic patients. Atherosclerosis 174, 127–132.CrossRefGoogle ScholarPubMed
Ramirez-Tortosa, MC, Urbano, G, López-Jurado, M, Nestares, T, Gomez, MC, Mir, A, Ros, E, Mataix, J & Gil, A (1999) Extra-virgin olive oil increases the resistance of LDL to oxidation more than refined olive oil in free-living men with peripheral vascular disease. J Nutr 129, 2177–2183.CrossRefGoogle ScholarPubMed
Reaven, PD & Witzum, JL (1996) Oxidized low density lipoproteins in atherogenesis: role of dietary modification. Annu Rev Nutr 16, 51–71.CrossRefGoogle ScholarPubMed
Ros, E (2003) Dietary cis -monounsaturated fatty acids and metabolic control in type 2 diabetes. Am J Clin Nutr 78, 617S–625S.CrossRefGoogle ScholarPubMed
Ros, E, Núñez, I, Pérez-Heras, A, Serra, M, Gilabert, R, Casals, E & Deulofeu, R (2004) A walnut diet improves endothelial function in hypercholesterolemic subjects. Circulation 109, 609–1614.CrossRefGoogle ScholarPubMed
Sanderson, P, Finnegan, YE, Williams, CM, Calder, PC, Birdge, GC, Wootton, SA, Griffin, BA, Millward, DJ, Pegge, NC & Bemelmans, WJE (2002) UK Food Standards Agency α-linolenic acid workshop. Br J Nutr 88, 573–579.CrossRefGoogle ScholarPubMed
Sanderson, P, Olthof, M, Grimble, RF, Calder, PC, Griffin, BA, de Roos, NM, Belch, JJF, Muller, DPR & Vita, JA (2004) Dietary lipids and vascular function: UK Food Standards Agency workshop report. Br J Nutr 91, 491–500.CrossRefGoogle ScholarPubMed
Schmidt, EB, Arnesen, H, De Caterina, R, Rasmussen, LH & Kristensen, SD (2005 a) Marine n-3 polyunsaturated fatty acids and coronary heart disease. Part I. Background, epidemiology, animal data, effects on risk factors and safety. Thromb Res 115, 163–170.CrossRefGoogle ScholarPubMed
Schmidt, EB, Arnesen, H, Christensen, JH, Rasmussen, LH, Kristensen, SD & De Caterina, R (2005 b) Marine n-3 polyunsaturated fatty acids and coronary heart disease. Part II: Clinical trials and recommendations. Thromb Res 115, 257–262.CrossRefGoogle ScholarPubMed
Segura, R, Javierre, C, Lizarraga, A & Ros, E (2006) Other relevant components of nuts: phytosterols, folate, and minerals. Br J Nutr 96, S36–S44.CrossRefGoogle ScholarPubMed
Spiller, GA, Miller, A, Olivera, K, Reynolds, J, Miller, B, Morse, SJ, Dewell, A & Farquhar, JW (2003) Effects of plant-based diets high in raw or roasted almonds, or roasted almond butter on serum lipoproteins in humans. J Am Coll Nutr 22, 195–200.CrossRefGoogle ScholarPubMed
Storlien, LH, Pan, DA, Kriketos, AD, O'Connor, J, Caterson, ID, Cooney, GJ, Jenkins, AB & Baur, LA (1996) Skeletal muscle membrane lipids and insulin resistance. Lipids 31, S261–S265.CrossRefGoogle ScholarPubMed
Theobald, HE, Chowienczyk, PJ, Whittall, R, Humphries, SE & Sanders, TAB (2004) LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women. Am J Clin Nutr 79, 558–563.CrossRefGoogle ScholarPubMed
West, SG (2001) Effect of diet on vascular reactivity: an emerging marker for vascular risk. Curr Atheroscler Rep 3, 446–455.CrossRefGoogle ScholarPubMed
Wijendran, V & Hayes, KC (2004) Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annu Rev Nutr 24, 597–615.CrossRefGoogle ScholarPubMed
Woollett, LA, Spady, DK & Dietschy, JM (1992) Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate. J Lipid Res 33, 77–88.CrossRefGoogle ScholarPubMed
World Health Organization (2002) Globalization Diet and Non Communicable Diseases. (NLM Classification QT 235). Geneva: World Health Organization.Google Scholar
Yu, S, Derr, J, Etherton, TD & Kris-Etherton, PM (1995) Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and monounsaturated fatty acids are hypocholesterolemic. Am J Clin Nutr 61, 1129–1139.CrossRefGoogle ScholarPubMed
Yu-Poth, S, Zhao, G, Etherton, T, Naglak, M, Jonnalagadda, S & Kris-Etherton, PM (1999) Effects of the National Cholesterol Education Program's Step I and Step II dietary intervention programs on cardiovascular disease risk factors: a meta-analysis. Am J Clin Nutr 69, 632–646.CrossRefGoogle ScholarPubMed
Zambón, D, Sabaté, J, Muñoz, S, Campero, B, Casals, E, Merlos, M, Laguna, JC & Ros, E (2000) Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women: a randomized crossover trial. Ann Intern Med 132, 538–546.CrossRefGoogle ScholarPubMed
Zhao, G, Etherton, TD, Martin, KR, West, SG, Gillies, PJ & Kris-Etherton, PM (2004) Dietary α-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J Nutr 134, 2991–2997.CrossRefGoogle ScholarPubMed