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Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal

Published online by Cambridge University Press:  09 March 2007

Jennifer L. Potts ,
Sandy M. Humphreys ,
Simon W. Coppack ,
Rachel M. Fisher ,
Geoffrey F. Gibbons  and
Keith N. Fray
Jennifer L. Potts
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
Sandy M. Humphreys
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
Simon W. Coppack
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
Rachel M. Fisher
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
Geoffrey F. Gibbons
Affiliation:
Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radclifle Infirmary, Oxford OX2 6HE
Keith N. Fray
Affiliation:
Oxford Lipid Metabolism Group, Sheikh Rashid Laboratory, Radclifle Infirmary, Oxford OX2 6HE
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Abstract

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The changes in lipoprotein metabolism which follow the ingestion of a large fat load have been well described. The hypothesis was tested that similar changes in lipoprotein metabolism would occur after a relatively normal meal. Plasma and lipoprotein triacylglycerol, cholesterol and apolipoprotein concentrations were determined in twenty subjects (ten female) given a mixed meal containing approximately one-third of the daily intake of major nutrients in the typical Western diet. Fasting plasma triacylglycerol concentrations (range 0.38–2.70 mm/l) and the postprandial rise in plasma triacylglycerol varied considerably between subjects and were significantly associated (P < 0.01). The rise in plasma triacylglycerol corresponded to marked increases in the triacylglycerol concentration of the triacylglycerol-rich lipoproteins (TRL; chylomicrons and very-low-density lipoproteins). TRL cholesterol also increased after the meal. An increase in high-density-lipoprotein (HDL)-triacylglycerol following the meal was accompanied by a decrease in HDL-cholesterol concentration, presumably due to the action of the cholesteryl-ester transfer protein. The increases in HDL-triacylglycerol and in TRL- cholesterol were correlated with the postprandial rise in triacylglycerol in the TRL (P < 0.01). We conclude that potentially adverse changes occur in both triacylglycerol-rich and high-density lipoproteins following a typical mixed meal, as they do after large fat loads. The changes are exaggerated in those subjects with greater fasting plasma triacylglycerol concentrations.

Keywords

Postprandial metabolismTriacylglycerolChylomicronsVery-lowdensity lipoprotein
Type
Effects of meals on plasma lipids
Information
British Journal of Nutrition , Volume 72 , Issue 1 , July 1994 , pp. 101 - 109
Copyright
Copyright © The Nutrition Society 1994

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