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Experimental zinc deficiency in guinea-pigs: clinical signs and some haematological studies

Published online by Cambridge University Press:  09 March 2007

R. P. Gupta ,
P. C. Verma  and
R. K. Paul Gupta
R. P. Gupta
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
P. C. Verma
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
R. K. Paul Gupta
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
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Abstract

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1. Thirty-three male, weanling guinea-pigs were divided into two groups. One group was fed on a zinc-deficient (ZnD) diet (1.25 mg Zn/kg diet) for 45 d and then divided into two subgroups: subgroup 1 continued on diet ZnD while subgroup 2 was fed on a Zn-repleted diet (100 mg Zn/kg diet) for 15 d. The second group was fed on a Zn-adequate diet (50 mg Zn/kg diet) for 60 d.

2. Zn deficiency could be produced within 21 d as evidenced by clinical signs and reduction in serum Zn concentration.

3. Clinical signs exhibited were listlessness, scabby lesions on skin near the foot pads, mild alopecia and a reduction in body-weight gain. No effect was observed on food intake.

4. Significant decreases in packed cell volume and total leucocyte count from 48 d onwards accompanied by absolute lymphocytopenia and relative neutrophilia were observed.

5. Supplementation of Zn in the Zn-repleted group resulted in marked, though incomplete, improvement with regard to serum Zn concentration, clinical signs and haematological changes.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 2 , September 1985 , pp. 421 - 428
Copyright
Copyright © The Nutrition Society 1985

References

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