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Experimental zinc deficiency in guinea-pigs: biochemical changes

Published online by Cambridge University Press:  09 March 2007

R. P. Gupta ,
P. C. Verma  and
R. K. Paul Gupta
R. P. Gupta
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
P. C. Verma
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
R. K. Paul Gupta
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
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Abstract

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1. Zinc deficiency was produced experimentally in guinea-pigs fed on a diet containing 1.25 mg Zn/kg diet over a period of 60 d. In addition, the response of the Zn-deficient (ZnD) animals to Zn supplementation was studied for 15 d.

2. In the ZnD group a significant reduction was found in serum Zn and protein concentrations and in alkaline phosphatase (EC 3. 1. 3. 1; AP) activity from day 24 onwards.

3. Paper electrophoretic studies on serum revealed a significant decrease in relative values, as well as absolute values, of albumin and γ-globulin and an increase in β-globulin.

4. Albumin:globulin increased on day 24 but decreased significantly from day 48 onwards.

5. The kidney and testis of the ZnD group showed a reduction in Zn and protein contents, and AP activity.

6. Zn supplementation of the previously ZnD group resulted in marked although incomplete improvement in the biochemical indices studied.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 3 , May 1986 , pp. 613 - 620
Copyright
Copyright © The Nutrition Society 1986

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