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Experimental nutritional folate deficiency in the baboon (Papio cynocephulus)

Published online by Cambridge University Press:  24 July 2007

R. C. Siddons
R. C. Siddons
Affiliation:
Wellcome Trust Research Laboratories, PO Box 43640, Nairobi, Kenya
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Abstract

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1. Folate deficiency was produced in baboons by feeding them on a diet which was deficient in folic acid.

2. Loss of body-weight, anorexia, asthenia, gingivitis and diarrhoea were common features of the deficiency.

3. Haematologically, the deficiency was characterized by leucopenia with a greater proportional decrease in the polymorphonuclear neutrophils, thrombocytopenia and in some baboons macrocytic anaemia.

4. Deficient baboons had low serum, erythrocyte and liver folate levels and excreted increased amounts of formiminoglutamic acid. The fall in the serum folate level was more rapid than that of the erythrocytes, occurring mainly during the 1st month of deficiency, while erythrocyte levels decreased gradually over a 5-month period.

5. Serum and liver vitamin B12 levels and methylmalonic acid excretion were normal in deficient baboons.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 32 , Issue 3 , November 1974 , pp. 579 - 587
Copyright
Copyright © The Nutrition Society 1974

References

REFERENCES

Chanarin, I. (1964). Proc. R. Soc. Med. 57, 384.Google Scholar
Chanarin, I. (1969 a). The Megaloblastic Anaemias p. 339. Oxford and Edinburgh: Blackwell Scientific Publications.Google Scholar
Chanarin, I. (1969 b). The Megaloblastic Anaemias p. 207. Oxford and Edinburgh: Blackwell Scientific Publications.Google Scholar
Chanarin, I. & Bennett, M. C. (1962). Br. med. J. i, 27.CrossRefGoogle Scholar
Chanarin, I., Hutchinson, M., McClean, A. & Moule, M. (1966). Br. med. J. i, 396.CrossRefGoogle Scholar
Chanarin, I., Smith, G. N. & Wincour, V. (1969). Br. J. Haemat. 16, 193.CrossRefGoogle Scholar
Dacie, J. V. & Lewis, S. M. (1969). Practical Haematology 4th ed.Edinburgh: Churchill.Google Scholar
Gutteridge, J. M. C. & Wright, E. B. (1970). Clinica chim. Acta 27, 289.CrossRefGoogle Scholar
Herbert, V. (1962). Trans. Ass. Am. Physns 75, 307.Google Scholar
Herbert, V. & Zalusky, R. (1962). J. clin. Invest. 41, 1263.CrossRefGoogle Scholar
Hoffbrand, A. V. & Newcombe, B. F. A. (1967). Br. J. Haemat. 13, 954.CrossRefGoogle Scholar
Hoffbrand, A. V., Newcombe, B. F. A. & Mollin, D. L. (1966). J. clin. Path. 19, 17.CrossRefGoogle Scholar
Huser, H. J. & Beard, M. E. J. (1969). Folia primatol. 10, 172.CrossRefGoogle Scholar
Johnson, S., Swaminathan, S. P. & Baker, S. J. (1962). J. din. Path. 15, 274.CrossRefGoogle Scholar
Leevy, C. M., TenHove, W., Frank, O. & Baker, H. (1964). Proc. Soc. exp. Biol. Med. 117, 746.CrossRefGoogle Scholar
Menzies, R. C., Crossen, P. E., Fitzgerald, P. H. & Gunz, F. W. (1966). Blood 28, 581.CrossRefGoogle Scholar
Spray, G. H. (1955). Clin. Sci. 14, 661.Google Scholar
Stokstad, E. L. R (1968). Vitams Horm. 26, 443.CrossRefGoogle Scholar
Waters, A. H. & Mollin, D. L. (1961). J. clin. Path. 14, 335.CrossRefGoogle Scholar
Waters, A. H. & Mollin, D. L. (1963). Br. J. Haemat. 9, 319.CrossRefGoogle Scholar
Weiss, H. J., Kelly, A. & Herbert, V. (1968). Blood 31, 258.CrossRefGoogle Scholar