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Exercise prevents the augmentation of postprandial lipaemia attributable to a low-fat high-carbohydrate diet

Published online by Cambridge University Press:  09 March 2007

Christina Koustsair  and
Adrianne E. Hardman
Christina Koustsair
Affiliation:
Human Muscle Metabolism Research Group, Department of Physical Education, Sports Science and Recreation Management, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
Adrianne E. Hardman*
Affiliation:
Human Muscle Metabolism Research Group, Department of Physical Education, Sports Science and Recreation Management, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
*
*Corresponding author: Professor Adrianne Hardman, fax +44 1509 223971, email [email protected]
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Abstract

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There is concern that replacement of dietary fat with carbohydrate may not reduce the overall risk of CHD because this replacement strategy elevates postprandial plasma triacylglycerol (TAG) concentrations. The present study was designed to test the hypothesis that daily exercise can offset the augmented postprandial lipaemia associated with a short-term high-carbohydrate diet. Nine healthy, normolipidaemic men aged 33 (SD 4) YEARS CONSUMED A TEST MEAL (G/KG BODY MASS; 1·2 FAT, 1·1 CARBOHYDRATE, 0·2 PROTEIN) ON THREE OCCASIONS: AFTER 3 D ON A TYPICAL WESTERN DIET (46, 38 AND 16 % ENERGY FROM CARBOHYDRATE, FAT AND PROTEIN RESPECTIVELY); AFTER 3 D ON AN ISOENERGETIC HIGH-CARBOHYDRATE DIET (CORRESPONDING VALUES: 70, 15 AND 15 % ENERGY); AFTER 3 D ON THE SAME HIGH-CARBOHYDRATE DIET WITH 30 MIN MODERATE EXERCISE DAILY. FASTING PLASMA TAG CONCENTRATION WAS HIGHER AFTER THE HIGH-CARBOHYDRATE DIET (1·15 (se 0·16) mmol/l) than after the Western diet (0·83 (se 0·10) mmol/l; P=0·03). Similarly, postprandial lipaemia (6 h total area under plasma TAG concentration v. time curve) was higher after the high-carbohydrate diet (12·54 (se 2·07) mmol/l·h) than after the Western diet (9·30 (se 1·30) mmol/l·h; P=0·004). The addition of exercise to the high-carbohydrate diet significantly reduced postprandial lipaemia (9·95 (se 1·94) mmol/l·h; P=0·01 when compared with the high-carbohydrate diet) but not fasting TAG concentration (1·02 (se 0·24) mmol/l). In conclusion, daily exercise prevented the augmentation of postprandial lipaemia attributable to the short-term high-carbohydrate diet and, thus, exercise may be a powerful adjunct to dietary change.

Keywords

High-carbohydrate dietModerate exercisePlasma triacylglycerolPostprandial lipaemia
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 2 , August 2001 , pp. 197 - 205
Copyright
Copyright © The Nutrition Society 2001

References

Annuzzi, G, Jansson, E, Kaijer, L, Holmquist, L & Carlson, LA (1987) Increased removal rate of exogenous triglycerides after prolonged exercise in man: time course and effect of exercise duration. Metabolism 36, 438–443.Google Scholar
Björkegren, J, Packard, CJ, Hamsten, A, Bedford, D, Caslake, M, Foster, L, Shepherd, J, Stewart, P & Karpe, F (1996) Accumulation of large VLDL in plasma during intravenous infusion of a chylomicron-like TAG emulsion reflects competition for a common lipolytic pathway. Journal of Lipid Research 37, 76–86.Google Scholar
Borg, GAV (1982) Psychophysical bases of perceived exertion. Medicine and Science in Sports and Exercise 14, 377–387.Google Scholar
Campos, H, Dreon, DM & Krauss, RM (1995) Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses. Journal of Lipid Research 36, 462–472.Google Scholar
Clevidence, BA, Judd, JT, Schatzkin, A, Muesing, RA, Campbell, WS, Brown, CC & Taylor, PR (1992) Plasma lipid and lipoprotein concentrations of men consuming a low-fat, high-fiber diet. American Journal of Clinical Nutrition 55, 689–694.Google Scholar
Connor, WE & Connor, SL (1997) Should a low-fat, high-carbohydrate diet be recommended for everyone? The case for a low-fat, high-carbohydrate diet. New England Journal of Medicine 337, 562–563.Google Scholar
Dreon, DM, Fernstrom, HA, Williams, PT & Krauss, RM (1999) A very-low-fat diet is not associated with improved lipoprotein profiles in men with predominance of large, low-density lipoproteins. American Journal of Clinical Nutrition 69, 411–418.Google Scholar
Durstine, JL & Haskell, WL (1994) Effects of exercise training on plasma lipids and lipoproteins. Exercise and Sports Science Reviews 22, 477–521.Google Scholar
Farese, RV, Yost, TJ & Eckel, RH (1991) Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans. Metabolism 40, 214–216.Google Scholar
Frayn, KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. Journal of Applied Physiology 55, 628–634.Google Scholar
Friedewald, WT, Levy, RI & Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18, 499–502.Google Scholar
Fukuda, N, Tojno, M, Hidaka, T, Sho, H & Sugano, M (1991) Reciprocal responses to exercise in hepatic ketogenesis and lipid secretion in the rat. Annals of Nutrition and Metabolism 35, 233–241.Google Scholar
Gill, JMR & Hardman, AE (1998) Reproducibility of lipaemic, insulinaemic and glycaemic responses to a high-fat mixed meal. Proceedings of the Nutrition Society 57, 122A.Google Scholar
Griffin, BA (1999) Lipoprotein atherogenicity: an overview of current mechanisms. Proceedings of the Nutrition Society 58, 163–169.Google Scholar
Hokanson, JE & Austin, MA (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. Journal of Cardiovascular Risk 3, 213–219.Google Scholar
Holland, B, Welch, AA, Unwin, ID, Buss, DH, Paul, A & Southgate, DAT (1991) The Composition of Foods, Cambridge: Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food.Google Scholar
Humphreys, SM, Fisher, RM & Frayn, KN (1990) Micro-method for measurement of sub-nanomole amounts of triacylglycerol. Annals of Clinical Biochemistry 27, 597–598.Google Scholar
Jeppesen, J, Schaaf, P, Jones, C, Zhou, M-Y, Chen, YI & Reaven, GM (1997) Effect of low-fat, high-carbohydrate diets on risk factors for ischemic heart disease in postmenopausal women. American Journal of Clinical Nutrition 65, 1027–1033.Google Scholar
Kantor, MA, Cullinane, EM, Sady, SP, Herbert, PN & Thompson, PD (1987) Exercise acutely increases high density lipoprotein-cholesterol and lipoprotein lipase activity in trained and untrained men. Metabolism 36, 188–192.Google Scholar
Karpe, F, Tornvall, P, Olivecrona, T, Steiner, G, Carlson, LA & Hamsten, A (1993) Composition of human low density lipoprotein: effects of postprandial triglyceride-rich lipoproteins, lipoprotein lipase, hepatic lipase and cholesteryl ester transfer protein. Atherosclerosis 98, 33–49.Google Scholar
Kasim-Karakas, SE, Almario, RU, Mueller, WM & Peerson, J (2000) Changes in plasma lipoproteins during low-fat, high-carbohydrate diets: effects of energy intake. American Journal of Clinical Nutrition 71, 1439–1447.Google Scholar
Katan, MB (1998) Effect of low-fat diets on plasma high-density lipoprotein concentrations. American Journal of Clinical Nutrition 67 Suppl., 573S–576S.Google Scholar
Koutsari, C, Malkova, D & Hardman, AE (2000) Postprandial lipemia after short-term variation in dietary fat and carbohydrate. Metabolism 49, 1150–1155.Google Scholar
Krauss, RM, Eckel, RH, Howard, BV, Appel, LJ, Daniels, SR, Deckelbaum, RJ, Erdman, JW, Kris-Etherton, P, Goldberg, IJ, Kotchen, T, Lichtenstein, AH, Mitch, WE, Mullis, R, Robinson, K, Wylie-Rosett, J, Jeor, SS, Suttie, J, Tribble, DL & Bazzarre, TL (2000) AHA dietary guidelines. Revision 2000: A statement for healthcare professionals from the nutrition committee of the American Heart Association. Circulation 102, 2284–2299.Google Scholar
Kris-Etherton, P (1999) Monounsaturated fatty acids and risk of cardiovascular disease. Circulation 100, 1253–1258.Google Scholar
Lewis, GF, Uffelman, KD, Szeto, LW, Weller, B & Steiner, G (1995) Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. Journal of Clinical Investigation 95, 158–166.Google Scholar
Matthews, JNS, Altman, DG, Campbell, MJ & Royston, P (1990) Analysis of serial measurements in medical research. British Medical Journal 300, 230–235.Google Scholar
Mensink, RP & Katan, MB (1992) Effect of dietary fatty acids on serum lipids and lipoproteins: a meta-analysis of 27 trials. Arteriosclerosis and Thrombosis 12, 911–919.Google Scholar
Miesenböck, G & Patsch, JR (1992) Postprandial hyperlipidemia: the search for the atherogenic lipoprotein. Current Opinion in Lipidology 3, 196–201.Google Scholar
Ministry of Agriculture, Fisheries and Food (1997) National Food Survey 1996. London: HM Stationery Office.Google Scholar
Parks, EJ, Krauss, RM, Christiansen, MP, Neese, RA & Hellerstein, MK (1999) Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance. Journal of Clinical Investigation 104, 1087–1096.Google Scholar
Pate, RR, Pratt, M, Blair, SN, Haskell, WL, Macera, CA, Bouchard, C, Buchner, D, Ettinger, W, Heath, GW, King, AC, Kriska, A, Leon, AS, Marcus, BH, Morris, J, Paffenbarger, RS, Patrick, K, Pollock, ML, Rippe, JM, Sallis, J & Wilmore, JH (1995) Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. Journal of the American Medical Association 273, 402–407.Google Scholar
Patsch, JR, Karlin, JB, Scott, LW, Smith, LC & Gotto, AM (1983) Inverse relationship between blood levels of high density lipoprotein subfraction 2 and the magnitude of postprandial lipemia. Proceedings of the National Academy of Science USA 80, 1449–1453.Google Scholar
Patsch, JR, Miesenböck, G, Hopferwieser, T, Muhlberger, V, Knapp, E, Dunn, JK, Gotto, AM Jr & Patsch, W (1992) Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arteriosclerosis and Thrombosis 12, 1336–1345.CrossRefGoogle ScholarPubMed
Rivellese, AA, Auletta, P, Marotta, G, Saldalamacchia, G, Giacoo, A, Mastrilli, V, Vaccaro, O & Riccardi, G (1994) Long term metabolic effects of two dietary methods of treating hyperlipidaemia. British Medical Journal 308, 227–231.Google Scholar
Sidossis, LS & Mittendorfer, B (1999) Effect of diet composition on triacylglycerol metabolism in humans. Clinical Nutrition 18, 107–109.Google Scholar
Taylor, HL, Burskirk, E & Henschel, A (1955) Maximal oxygen uptake as an objective measure of cardio-respiratory fitness. Journal of Applied Physiology 8, 73–80.Google Scholar
Thompson, PD, Cullinane, EM, Sady, SP, Flynn, MM, Bernier, DN, Kantor, MA, Saritelli, AL & Herbert, PN (1988) Modest changes in high-density lipoprotein concentration and metabolism with prolonged exercise training. Circulation 78, 25–34.Google Scholar
Tsetsonis, NV & Hardman, AE (1996) Effects of low and moderate intensity treadmill walking on postprandial lipaemia in healthy young adults. European Journal of Applied Physiology 73, 419–426.Google Scholar
Tsetsonis, NV, Hardman, AE & Mastana, SS (1997) Acute effects of exercise on postprandial lipemia: a comparative study in trained and untrained middle-aged women. American Journal of Clinical Nutrition 65, 525–533.Google Scholar
Ullrich, IH & Albrink, MJ (1986) Physical fitness modifies carbohydrate-induced lipemia. Nutrition Reports International 33, 701–709.Google Scholar
Weintraub, MS, Rosen, Y, Otto, R, Eisenberg, S & Breslow, JL (1989) Physical exercise conditioning in the absence of weight loss reduces fasting and postprandial triglyceride-rich lipoprotein levels. Circulation 79, 1007–1014.Google Scholar
Zavaroni, I, Chen, YI, Mondon, CE & Reaven, GM (1981) Ability of exercise to inhibit carbohydrate-induced hypertriglyceridemia in rats. Metabolism 30, 476–480.Google Scholar