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The excretion of selenium in bile and urine of steers: the influence of form and amount of Se salt

Published online by Cambridge University Press:  09 March 2007

H. W. Symonds ,
Denise L. Mather  and
M. J. Vagg
H. W. Symonds
Affiliation:
Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 0NN
Denise L. Mather
Affiliation:
Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 0NN
M. J. Vagg
Affiliation:
Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 0NN
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Abstract

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1. The excretion of 75Se and stable Se in bile and urine was measured in four steers during 6 h after intravenous injections of 75Se as either selenite or selenate containing either 5 or 5000 μg carrier Se.

2. When 5000 μg Se were given, the rate of urinary excretion and plasma clearance of 75Se was similar for both salts. Approximately 23% was excreted in urine and plasma clearance was triexponential, the mean half-life (t½) of the successive components, α, β and γ, being 2·3, 15·2 and 465 min respectively. The amount of 75Se excreted in bile was small; 1·94% of the 75SeO32− and 0·86% of the 75SeO42− dose.

3. When 5 μg Se were given the plasma clearance of 75Se was initially biexponential but the entry of 75Se-labelled protein from the liver caused an increase in plasma radioactivity after 30–40 min. The effect was most marked after 5 μg 75SeO32− when plasma 75Se radioactivity returned to 60% of the activity present at 2 min. Values for t½ of the two components of clearance for 75SeO32− and 75SeO42− were respectively α 2·6 and 2·5 min, and β 15·9 and 36·6 min. Similar amounts of 75Se appeared in bile (0·2% of the dose) after injections of either salt but much less 75Se was excreted in urine after 75SeO32− (6%) than after 75SeO42− (37%).

4. At low dosage rates (5 μg) Se is more readily incorporated into tissues from SeO32− than from SeO42−.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 46 , Issue 3 , November 1981 , pp. 487 - 493
Copyright
Copyright © The Nutrition Society 1981

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