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Essential fatty acids in the liver and adipose tissue of genetically obese mice: effect of supplemental linoleic and γ-linolenic acids

Published online by Cambridge University Press:  24 July 2007

S. C Cunnane ,
M. S. Manku  and
D. F. Horrobin
S. C Cunnane
Affiliation:
Efamol Research Institute, PO Box 818, Kentville, Nova Scotia, CanadaB4N 4H8
M. S. Manku
Affiliation:
Efamol Research Institute, PO Box 818, Kentville, Nova Scotia, CanadaB4N 4H8
D. F. Horrobin
Affiliation:
Efamol Research Institute, PO Box 818, Kentville, Nova Scotia, CanadaB4N 4H8
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Abstract

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1. Genetically obese mice (ob/ob) and their lean litter-mates were given diets iso-energetically supplemented with sucrose, hydrogenated coconut oil, safflower oil or evening primrose (Oenothera biennis) oil.

2. Weight gain over 15 weeks was significantly greater in the evening primrose oil-supplemented obese mice than in the other groups.

3. In all the groups of obese mice, liver total phospholipids contained proportionally less linoleic acid and more dihomo-γ-linolenic acid and arachidonic acid than did the lean controls.

4. As a percentage of total fatty acids, n-3 essential fatty acids (EFA) in liver and adipose tissue lipids were significantly lower in the obese mice than in the lean controls.

5. Supplementation with EFA-rich oils (safflower and evening primrose oil) increased the proportional composition of n-6 EFA and decreased the n-3 EFA more in the liver total phospholipids of the lean than the obese mice.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 53 , Issue 3 , May 1985 , pp. 441 - 448
Copyright
Copyright © The Nutrition Society 1985

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