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Energy metabolism of young rats after early postnatal overnutrition

Published online by Cambridge University Press:  09 March 2007

Petra Wiedmer ,
Sylvia Ortmann  and
Susanne Klaus
Petra Wiedmer
Affiliation:
Department of Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition (DlfE) 14558 Potsdam-Rehbrücke, Germany
Sylvia Ortmann
Affiliation:
Department of Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition (DlfE) 14558 Potsdam-Rehbrücke, Germany
Susanne Klaus*
Affiliation:
Department of Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition (DlfE) 14558 Potsdam-Rehbrücke, Germany
*
*Corresponding author: Dr Susanne Klaus, fax +49 33 200/88 500, email [email protected]
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Abstract

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Early postnatal overnutrition (PNO) induced by restricting litter size in rats leads to increased body-weight (BW) and body-fat gain in later life. PNO rats are used as an animal model of moderate obesity and early hyperinsulinism. We investigated whether the increased adiposity could be due to a decreased energy expenditure. Male newborn Wistar rats were raised in litters of either two (SL) or twelve pups (NL), weaned at 4 weeks of age and subsequently fed ad libitum. BW was recorded continuously until 12 weeks of age. Daily energy intake, total daily energy expenditure (EE, measured by indirect calorimetry) and body composition were measured in weaned pups at 5, 8 and 12 weeks of age. SL rats displayed increased BW compared with NL rats from week 2 to 5 and again from week 10 to 12. Lean body mass, body fat and protein content and total EE were increased in SL rats at week 5. The same linear correlation described the relationship between BW and total EE in NL and SL rats. At week 8 to 12 no differences in energy metabolism could be found, but the total fat content was increased in SL rats at week 12. Energy balance, i.e. assimilated energy minus EE, was no different between SL and NL at any time that it was measured. We conclude that although PNO rats display increased adiposity in early life, there seem to be no long-lasting effects on energy metabolism in later life, even if a tendency to increased adiposity can still be detected.

Keywords

ObesityEnergy expenditureSmall littersBody composition
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue 3 , September 2002 , pp. 301 - 306
Copyright
Copyright © The Nutrition Society 2002

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