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The effects of vitamin E supplementation on autoimmune-prone New Zealand black × New Zealand white F1 mice fed an oxidised oil diet

Published online by Cambridge University Press:  08 March 2007

Chia-Chien Hsieh  and
Bi-Fong Lin
Chia-Chien Hsieh
Affiliation:
Laboratory of Nutritional Chemistry, Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan, 10764, Republic of China
Bi-Fong Lin*
Affiliation:
Laboratory of Nutritional Chemistry, Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan, 10764, Republic of China
*
*Corresponding author: Dr Bi-Fong Lin, fax +886 2 23621301, email [email protected]
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Abstract

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The purpose of the present study was to investigate the effect of vitamin E supplementation on autoimmune disease in New Zealand black×New Zealand white F1 (NZB/W F1) female mice fed an oxidised oil diet. First, 5-month-old mice were fed an AIN-76 diet containing either 150 g fresh soyabean oil/kg (15S), 50 g fresh soyabean oil/kg + 100 g oxidised frying oil/kg (5S10F) or 5S10F supplemented with all-rac-α-tocopheryl acetate at 275 mg/kg diet level (5S10F5E) or 550 mg/kg (5S10F10E), respectively, in experiment 1. The results showed that mice fed the 5S10F10E diet had a lower anti-double-stranded DNA IgG antibody level and a longer lifespan than those fed the 15S and 5S10F diets. Therefore, the 5S10F and 5S10F10E treatments were repeated in experiment 2 for further analysis. The results showed that vitamin E supplementation in the oxidised oil significantly decreased thiobarbituric acid-reactive substance values in the kidney and spleen of NZB/W F1 mice. Interferon-γ and IL-6 production by mitogen-stimulated splenocytes decreased in mice fed the 5S10F10E diet, whereas the secretion of IL-2 and IL-10 was not affected. The percentage of T-cells was significantly higher and that of MHC class II-bearing cells was lower in the spleens of the 5S10F10E group. The 5S10F10E group had a significantly higher linoleic acid (18: 2n-6) composition than the 5S10F diet group. Therefore, vitamin E supplementation in oxidised oil might decrease oxidative stress, anti-double-stranded DNA IgG antibody, regulate cytokines and lymphocyte subsets, and subsequently alleviate the severity of autoimmune disease such as systemic lupus erythematosus under oxidative stress.

Keywords

Vitamin EOxidised oilNZB/W F1 miceSystemic lupus erythematosus
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 5 , May 2005 , pp. 655 - 662
Copyright
Copyright © The Nutrition Society 2005

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