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Effects of preweaning nutritional deprivation on basal metabolism and thermoregulatory thermogenesis in the rat

Published online by Cambridge University Press:  09 March 2007

D. V. Muralidhara  and
P. S. Shetty
D. V. Muralidhara
Affiliation:
Nutrition Research Centre (ICMR), Department of Physiology, St. John's Medical College, Bangalore 560 034, India
P. S. Shetty
Affiliation:
Nutrition Research Centre (ICMR), Department of Physiology, St. John's Medical College, Bangalore 560 034, India
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Abstract

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1. Nutritional deprivation was induced preweaning in Wistar rats by increasing the litter size to sixteen, while paired litters with only five pups served as controls. The nutritionally deprived pups were rehabilitated after weaning by ad lib. access to an adequate diet.

2. The body-weights and body lengths were significantly lower in the nutritionally deprived group and significant differences persisted even after 9 weeks of rehabilitation.

3. The body temperature of the nutritionally deprived animals was significantly lower than that of their paired controls, both before and following nutritional rehabilitation, except for a short period after weaning when the nutritionally deprived animals were initially given the diet ad lib.

4. The resting oxygen consumption of the nutritionally deprived animals was comparable to that of the controls when corrected for metabolic body size, both before and after weaning. Noradrenaline-stimulated increase in 02 consumption (non-shivering thermogenesis; NST) was reduced by 50% at weaning in the nutritionally deprived animals and returned to levels comparable to those of controls within a short period of rehabilitation.

5. The decrease in NST capacity seen in the nutritionally deprived animals was associated with an inability to thermoregulate when exposed to cold (5°), resulting in death. Cold-induced thermogenesis (CIT) also reappeared soon after nutritional rehabilitation.

6. Reduction in metabolic rate, NST and CIT seen in the animals nutritionally deprived preweaning was short-lived and disappeared soon after nutritional rehabilitation. Rapid reversal of these physiological changes indicates that they do not confer any long-term benefit or change in metabolic efficiency and are unlike the changes in body size and growth which do not completely recover following nutritional rehabilitation.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 3 , November 1986 , pp. 615 - 623
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Apfelbaum, M. (1978). Progress in Food and Nutrition Science 2, 543–559.Google Scholar
Ashworth, A. (1969). Nature 223, 407–409.Google Scholar
Brenton, D. P., Brown, R. E. & Wharton, B. A. (1967). Lancet i, 410–413.Google Scholar
Davis, T. R. A. & Mayer, J. (1954). American Journal of Physiology 177, 222–226.CrossRefGoogle Scholar
Dorner, G. (1974). Acta Biologica et Medica Germanica 33, 129–148.Google Scholar
Forsum, E., Hillman, P. E. & Nesheim, M. C. (1981). Journal of Nutrition 111, 1691–1697.Google Scholar
Grande, F. (1964). In Handbook of Physiology. Sect. 4, pp. 911–937 [Dill, D. B., editor]. Washington, D. C.: American Physiological Society.Google Scholar
Hoyenga, K. B. & Hoyenga, K. T. (1982). Physiology and Behaviour 28, 545–563.Google Scholar
Jansky, L. (1973). Biological Reviews of the Cambridge Philosophical Society 48, 85–132.CrossRefGoogle Scholar
Khan, M. A. & Bender, A. E. (1979). Nutrition and Metabolism 23, 449–457.CrossRefGoogle Scholar
Kibler, H. H. & Brody, S. (1942). Journal of Nutrition 24, 461–468.Google Scholar
Kleiber, M. (1947). Physiological Reviews 27, 511–541.Google Scholar
Mccance, R. A. (1976). In Early Nutrition and Later Development, pp. 149–155 [Wilkinson, A. W., editor]. London: Pitman Medical Publishing Co.Google Scholar
McCance, R. A. & Mount, L. E. (1960). British Journal of Nutrition 14, 509–518.CrossRefGoogle Scholar
Mitchell, H. H. (1962). In Comparative Nutrition of Man and Domestic Animals, vol. 1, pp. 3–90. New York: Academic Press.CrossRefGoogle Scholar
Mohan, P. F. & Narasinga Rao, B. S. (1983). Journal of Nutrition 113, 79–85.CrossRefGoogle Scholar
Muralidhara, D. V. & Shetty, P. S. (1983). Indian Journal of Physiology and Pharmacology 27, 345–349.Google Scholar
Rothwell, N. J. & Stock, M. J. (1980). Canadian Journal of Physiology and Pharmacology 58, 842–848.Google Scholar
Shetty, P. S., Jung, R. J. & James, W. P. T. (1979). Lancet i, 77–79.Google Scholar
Trayhurn, P. (1979). Pflügers Archiv 380, 227–232.Google Scholar
Trayhurn, P. (1983). Pflügers Archiv 398, 264–265.CrossRefGoogle Scholar
Trayhurn, P., Douglas, J. B. & McGuckin, M. M. (1982). Nature 298, 59–60.CrossRefGoogle Scholar
Trayhurn, P. & James, W. P. T. (1978). Pflügers Archiv 373, 189–193.CrossRefGoogle Scholar
Trayhurn, P. & James, W. P. T. (1981). In The Body Weight Regulatory System: Normal and Disturbed Mechanisms, pp. 97–105 [Cioffi, A. L., James, W. P. T. and Van Itallie, T. B., editors]. New York: Raven Press.Google Scholar
Viteri, F. E. & Torun, B. (1980). IN Modern Nutrition in Health and Disease, pp. 697–720 [Goodhard, R. S. and Shills, M. F., editors]. Philadelphia: L and F.Google Scholar
Widdowson, E. M. & McCance, R. A. (1960). Proceedings of the Royal Society, Series B 152, 188–206.Google Scholar
Wurtman, J. J. & Miller, S. A. (1976). Journal of Nutrition 106, 697–701.Google Scholar