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Effects of oat rye fractions on biliary and faecal bile acid profiles in Syrian golden hamsters (Mesocricetus auratus)

Published online by Cambridge University Press:  09 March 2007

Jie-Xian Zhang ,
Göran Hallmans ,
Herman Adlercreutz ,
Per Åman ,
Eric Westerland ,
Eva Lundin  and
Roger Stenling
Jie-Xian Zhang
Affiliation:
Departments of Pathology and University of Umeå, S-901 87 Umeå, Sweden Departments of Nutritional Research, University of Umeå, S-901 87 Umeå, Sweden
Göran Hallmans
Affiliation:
Departments of Pathology and University of Umeå, S-901 87 Umeå, Sweden Departments of Nutritional Research, University of Umeå, S-901 87 Umeå, Sweden
Herman Adlercreutz
Affiliation:
Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, SF-00290 Helsinki, Finland
Per Åman
Affiliation:
Department of Food Sciences, Swedish University of Agricultural Sciences, S-750 07 Uppsala, Sweden
Eric Westerland
Affiliation:
Department of Food Sciences, Swedish University of Agricultural Sciences, S-750 07 Uppsala, Sweden
Eva Lundin
Affiliation:
Departments of Pathology and University of Umeå, S-901 87 Umeå, Sweden Departments of Nutritional Research, University of Umeå, S-901 87 Umeå, Sweden
Roger Stenling
Affiliation:
Departments of Pathology and University of Umeå, S-901 87 Umeå, Sweden Departments of Nutritional Research, University of Umeå, S-901 87 Umeå, Sweden
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Abstract

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The effects of bran and starchy endosperm fractions of oat and rye on faecal weight and on biliary and faecal bile acids were studied in Syrian golden hamsters (Mesocricetus auratus). The animals fed on diets supplemented with steam-flaked oat bran, oat bran or rye bran had higher wet and dry weights of faeces compared with the animals fed on the fibre-free or low-fibre endosperm diets. A higher mean percentage of biliary cholic acid and a lower mean percentage of chenodeoxycholie and lithocholic (LCA) acids was observed in the bran-supplemented dietary groups. Animals fed on the bran-supplemented diets had increased daily faecal excretion of both total saponifiable and total free bile acids compared with the animals fed on fibre-free or endosperm-supplemented diets. The mean percentage of total saponifiable bile acids in the faeces was higher, and that of free bile acids lower in the animals fed on bran-supplemented diets. A significantly lower concentration of faecal free LCA was observed in the animals fed on the rye-bran diet. Both bran and endosperm diets reduced the faecal LCA: deoxycholic acid compared with the fibre-free diet, but the bran diets had a more pronounced effect than endosperm diets.

Keywords

OatsRyeBile acidsHamsters
Type
Effects of Complex Carbohydrates on Lipid Metabolism
Information
British Journal of Nutrition , Volume 70 , Issue 2 , September 1993 , pp. 525 - 536
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Åman, P. & Graham, H. (1987). Analysis of total and insoluble mixed-linked (1→3),(1→4)-β-D-glucans in barley and oats. Journal of Agricultural and Food Chemistry 35, 704–709.CrossRefGoogle Scholar
Anderson, J. W., Spencer, D. B., Hamilton, C., Smith, S. F., Tietyen, J., Bryant, C. A. & Oeltgen, P. (1990). Oat-bran cereal lowers serum total and LDL cholesterol in hypercholesterolemic men. American Journal of Clinical Nutrition 52, 495–499.CrossRefGoogle ScholarPubMed
Anon (1984). Determination of crude oils and fats. Official Journal of the European Communities L15, 29–30.Google Scholar
Association of Official Analytical Chemists (1990). Official Methods of Analysis. vol. I. Agricultural Chemicals; Contaminants; Drugs, 15th ed, pp. 70, 74. Washington DC: Association of Official Analytical Chemists.Google Scholar
Bosaeus, I., Carlsson, N. G. & Anderson, H. (1986). Low-fat versus medium fat enteral diets. Scandinavian Journal of Gastroenterology 21, 891–896.CrossRefGoogle ScholarPubMed
Brydon, W. G., Eastwood, M. A. & Elton, R. A. (1988). The relationship between stool weight and the lithocholate/deoxycholate ratio in faeces. British Journal of Cancer 57, 635–636.CrossRefGoogle ScholarPubMed
Chen, W.-J. L. & Anderson, J. W. (1981). Effects of oat bran, oat gum and pectin on lipid metabolism of cholesterol-fed rats. Nutrition Reports International 24, 1093–1098.Google Scholar
Gold, K. V. & Davidson, D. M. (1988). Oat bran as a cholesterol-reducing adjunct in a young, healthy population. Western Journal of Medicine 148, 299–302.Google Scholar
Greenwald, P., Lanza, E. & Eddy, G. A. (1987). Dietary fibre in the reduction of colon cancer risk. Journal of The American Dietetic Association 87, 1178–1188.CrossRefGoogle ScholarPubMed
Henry, R. J. (1987). Pentosan and (1–3),(1–4)-β-glucan concentrations in endosperm and whole grain of wheat, barley, oats, and rye. Journal of Cereal Science 6, 253–258.CrossRefGoogle Scholar
Hurt, H. D., Mathews, R. & Ink, S. (1988). Biological Considerations of Oat Dietary Fibre and Beta-glucans. Proceedings of 3rd International Oat Conference, Lund, Sweden, pp. 10–12.Google Scholar
Illman, R. J. & Topping, D. L. (1985). Effect of dietary oat bran on faecal steroid excretion, plasma volatile fatty acids and lipid synthesis in rats. Nutrition Research 5, 839–846.CrossRefGoogle Scholar
Jenkins, D. J. A., Jenkins, A. L., Rao, A. V. & Thompson, L. U. (1986). Cancer risk: Possible protective role of high carbohydrate high fiber diets. American Journal of Gastroenterology 81, 931–935.Google ScholarPubMed
Judd, P. A. & Truswell, A. S. (1981). The effect of rolled oats on blood lipids and fecal steroid excretion in man. American Journal of Clinical Nutrition 34, 2061–2067.CrossRefGoogle ScholarPubMed
Kelsey, M. I. & Sexton, S. A. (1976). The biosynthesis of ethyl esters of lithocholic acid and isolithocholic acid by rat intestinal microflora. Journal of Steroid Biochemistry 7, 641–647.CrossRefGoogle ScholarPubMed
Korpela, J. T., Adlercreutz, H. & Turunen, M. J. (1988). Fecal free and conjugated bile acids and neutral sterols in vegetarians, omnivores, and patients with colorectal cancer. Scandinavian Journal of Gastroenterology 23, 277–283.CrossRefGoogle ScholarPubMed
Korpela, J. T., Fotsis, T. & Adlercreutz, H. (1986). Multicomponent analysis of bile acids in faeces by anion exchange and capillary column gas-liquid chromatography: Application in oxytetracycline treated subjects. Journal of Steroid Biochemistry 25, 277–284.CrossRefGoogle ScholarPubMed
Korpela, J. T., Korpela, R. & Adlercreutz, H. (1992). Fecal bile acid metabolic pattern after administration of different types of bread. Gastroenterology 103, 1246–1253.CrossRefGoogle ScholarPubMed
Kritchevsky, D. (1986). Diet, nutrition and cancer. The role of fibre. Cancer 58, 1830–1836.3.0.CO;2-K>CrossRefGoogle Scholar
Mullan, F. J., Wilson, H. K., Majury, C. W., Mills, J. O. M., Cromie, A. J., Campbell, G. R. & McKelvey, S. T. D. (1990). Bile acids and the increased risk of colorectal tumours after truncal vagotomy. British Journal of Surgery 77, 1085–1090.CrossRefGoogle ScholarPubMed
Nair, P. P. (1988). Role of bile acids and neutral sterols in carcinogenesis. American Journal of Clinical Nutrition 48, 768–774.CrossRefGoogle ScholarPubMed
Norman, A. (1964). Faecal excretion products of cholic acid in man. British Journal of Nurrition 18, 173–186.CrossRefGoogle ScholarPubMed
Owen, R. W., Dodo, M., Thompson, M. H. & Hill, M. J. (1983). The faecal ratio of lithocholic acid to deoxycholic acid may be an important aetiological factor in colorectal cancer. European Journal of Cancer and Clinical Oncology 19, 1307.Google Scholar
Owen, R. W., Dodo, M., Thompson, M. H. & Hill, M. J. (1987). Fecal steroid and colorectal cancer. Nutrition and Cancer 9, 76–80.CrossRefGoogle ScholarPubMed
Qureshi, A. A., Chaudhary, V., Weber, F. E., Chicoye, E. & Qureshi, N. (1991). Effects of brewer's grain and other cereals on lipid metabolism in chickens. Nutrition Research 11, 159–168.CrossRefGoogle Scholar
Rafter, J., Geltner, U. & Bruce, R. (1987). Cellular toxicity of human faecal water 7ndah; possible role in aetiology of colon cancer. Scandinavian Journal of Gastroenterology 22 (Suppl. 129), 245–250.CrossRefGoogle Scholar
Shaw, R. & Elliott, W. H. (1978). Bile acids. LV. 2,2-dimethoxypropane: an esterifying agent preferred to diazomethane for chenodeoxycholic acid. Journal of Lipid Research 19, 783–787.CrossRefGoogle Scholar
Shinnick, F. L., Longacre, M. L., Ink, S. L. & Marlett, J. A. (1988). Oat fibre: Composition versus physiological function in rats. Journal of Nutrition 118, 144–151.CrossRefGoogle ScholarPubMed
Theander, O. & Westerlund, E. (1986). Studies on dietary fiber. 3. Improved procedures for analysis of dietary fiber. Journal of Agricultural and Food Chemistry 34, 330–336.CrossRefGoogle Scholar
Turjman, N., Goodman, G. T., Jaeger, B. & Nair, P. P. (1984). Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer. Metabolism of bile acids. American Journal of Clinical Nutrition 40, 937–941.CrossRefGoogle ScholarPubMed
Westerlund, E., Andersson, R. & Åman, P. (1993). Isolation and chemical characterisation of water-soluble mixed-linked β-glucans and arabinoxylans in oat milling iractions. Carbohydrate Polymers 20, 115–124.CrossRefGoogle Scholar
Zhang, J. X., Hallmans, G., Andersson, H., Bosaeus, I., Åman, P., Tidehag, P., Stenling, R., Lundin, E. & Dahlgren, S. (1992). Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects with ileostomies. American Journal of Clinical Nutrition 56, 99–105.CrossRefGoogle ScholarPubMed