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Effects of moderate increases in dietary polyunsaturated: saturated fat on plasma triglyceride and cholesterol levels in man

Published online by Cambridge University Press:  24 July 2007

Fredric B. Kraemer ,
Michael Greenfield ,
Ted A. Tobey  and
Gerald M. Reaven
Fredric B. Kraemer
Affiliation:
Department of Medicine, Stanford University School of Medicine and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center (182 B), Palo Alto, California 94304
Michael Greenfield
Affiliation:
Department of Medicine, Stanford University School of Medicine and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center (182 B), Palo Alto, California 94304
Ted A. Tobey
Affiliation:
Department of Medicine, Stanford University School of Medicine and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center (182 B), Palo Alto, California 94304
Gerald M. Reaven
Affiliation:
Department of Medicine, Stanford University School of Medicine and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center (182 B), Palo Alto, California 94304
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Abstract

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1. The effects of two isoenergetic diets differing only in the values for polyunsaturated: saturated fat (P : S values of 0·2 v. 2·0) were studied in twenty adult human volunteers.

2. A period of 14 d on the high P:S diet failed to produce significant changes in fasting triglyceride levels, though there were individual variations. On the other hand, fasting cholesterol levels dropped by 10% (P < 0.005). High-density-lipoprotein-cholesterol concentrations were not influenced by changes in the P:S value.

3. Investigations into the mechanism by which changes in the P:S value might affect plasma triglyceride values revealed no consistent effects on very-low-density-lipoprotein kinetics, insulin secretion, insulin sensitivity or free fatty acid concentrations.

4. The results of this study suggest that the largest increase in dietary P:S values that is likely to be obtained on a long-term basis may have only a small effect on plasma triglyceride and cholesterol concentration.

Type
Papers of direct reference to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 47 , Issue 2 , March 1982 , pp. 259 - 266
Copyright
Copyright © The Nutrition Society 1982

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