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Effects of milk-derived bioactives: an overview

Published online by Cambridge University Press:  09 March 2007

Nagendra P. Shah*
Affiliation:
School of Life Science and Technology, Victoria University of Technology, PO Box 14428, Melbourne City Mail Centre, Victoria 8001, Australia
*
*Corresponding author: Nagendra P. Shah, Professor N. P. Shah, fax +61 3 9216 8284, email [email protected]
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Abstract

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Milk contains various components with physiological functionality. Peptides derived from caseins and whey proteins including opioid peptides, antihypertensive peptides, casein phosphopeptides, α- and β-lactorphins and albutensin have been shown to possess various bioactive properties. This review considers an overview of the bioactive components in milk proteins and whey and their physiological function.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2000

References

Antila, P, Paakkari, I, Jarvinen, A, Mattila, MJ, Laukkanen, M, Pihlanto-Leppala, A, Mantsala, P & Hellman, J (1991) Opioid peptides derived from in vitro proteolysis of bovine whey proteins. International Dairy Journal 1, 215229.CrossRefGoogle Scholar
Batish, VK, Chander, H, Zumdegeni, KC, Bhatia, KL & Singh, RS (1988) Antibacterial activity of lactoferrin against some common food-borne pathogenic organisms. Australian Journal of Dairy Technology 5, 1618.Google Scholar
Bicknell, RS (1985) Endogenous opioid peptides and hypothalamic neuroendocrine neurons. Scandanavian Endocrinology 107, 43.Google Scholar
Brommage, R, Juillerat, MA & Jost, R (1991) Influence of casein phosphopeptide and lactulose on intestinal calcium absorption in adult female rats. Lait 71, 173180.Google Scholar
Daniel, H, Vohwinkel, M & Rehner, G (1990) Effect of casein and β-casomorphin on gastrointestinal motility in rats. Journal of Nutrition 120, 252257.CrossRefGoogle ScholarPubMed
Dave, RI & Shah, NP (1997) Viability of yoghurt and probiotic bacteria in yoghurt made from commercial starter cultures. Interernational Dairy Journal 7, 3141.CrossRefGoogle Scholar
Davidson, GP (1996) Passive protection against diarrheal disease. Journal of Paediatric Gastroenterology and Nutrition 23, 207212.Google Scholar
Djouzi, Z & Andrieux, C (1997) Compared effects of three oligosaccharides on metabolism of intestinal microflora in rats inoculated with human faecal flora. British Journal of Nutrition 78, 313324.Google Scholar
Fiat, AM, Migliore-Samour, D, Jolles, P, Drouet, I, Bal, Dit, Soitier, C & Caen, J (1993) Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities. Journal of Dairy Science 76, 301310.CrossRefGoogle ScholarPubMed
Gibson, GR & Roberfroid, MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Journal of Nutrition 125, 14011412.CrossRefGoogle ScholarPubMed
Goldman, AS (1989) Immunologic supplementation of cow's milk formulations. Bulletin of the International Dairy Federation 244, 3842.Google Scholar
Goldman, AS & Goldblum, RM (1995) Defense agents in milk: A. defense agents in human milk. In Handbook of Milk Composition, pp. 727748 [Jensen, R, editor]. New York: Academic Press.CrossRefGoogle Scholar
Hutchens, TW, Rumball, SV & Lonnerdal, B (1994) Lactoferrin: structure and function. Advances in Experimental Medical and Biological 357, 1298.Google Scholar
Jelen, P & Lutz, S (1998) Functional milk and dairy products. In Functional Foods: Biochemical and Processing Aspects, pp. 357380 [Mazza, FG, editor]. Lancaster: Technomic Publ. Co., Inc.Google Scholar
Jones, EM, Smart, A, Bloomberg, G, Burgess, L & Millar, MR (1994) Lactoferricin, a new antimicrobial peptide. Journal of Applied Bacteriology 77, 208214.CrossRefGoogle ScholarPubMed
Kitts, DD & Yuan, YV (1992) Caseinophosphopeptides and calcium bioavailability. Trends in Food Science and Technology 3, 31.CrossRefGoogle Scholar
Korhonen, H (1977) Antimicrobial factors in bovine colostrum. Journal of the Scientific Agricultural Society of Finland 49, 434447.Google Scholar
Korhonen, H, Pihlanto-Leppala, A, Rantamaki, P & Tupasela, T (1998) The functional and biological properties of whey proteins: prospects for the development of functional foods. Agriculture and Food Science in Finland 7, 283296.CrossRefGoogle Scholar
Kussendrager, K (1993) Lactoferrin and lactoperoxidase: bioactive milk proteins. International Food Ingredients 6, 1721.Google Scholar
Lahov, E & Regelson, W (1996) Antibacterial and immunostimulating casein-derived substances from milk: caseicidin, isracidin peptides. Food and Chemical Toxicology 34, 131145.CrossRefGoogle ScholarPubMed
Lankaputhra WEV (1997) Viability and therapeutic properties of probiotic bacteriaPhD Thesis.Google Scholar
Lankaputhra, WEV & Shah, NP (1998) Antimutagenic properties of probiotic bacteria and of organic acids. Mutation Research 397, 169182.Google Scholar
Loukas, L, Varoucha, D, Ziodrou, C, Straty, RA & Kice, WA (1983) Opioid activities and structure of α-casein-derived exorphins. Biochemie 22, 4567.CrossRefGoogle ScholarPubMed
McIntosh, GH, Jorgensen, L & Royle, PJ (1993) The potential of an insoluble dietary fibre-rich source from barley to protect from DMH-induced intestinal tumors in rats. Nutrition and Cancer 19, 213.Google Scholar
McIntosh, GH, Regester, GO, Le Leu, RK, Royle, PJ & Smithers, GW (1995) Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats. Journal of Nutrition 125, 809816.Google Scholar
McLeod, A, Fedio, W, Chu, L & Ozimek, L (1996) Binding of retionoic acid to β-lactoglobulin variants A and B: effect of hepatic and tryptic digestion on the protein-ligand complex. Milchwissenschaft 51, 37.Google Scholar
Maruyama, S & Suzuki, H (1982) A peptide inhibitor of angiotensin I-converting enzyme inhibitor in the tryptic hydrolysates of casein. Agriculture Biological Chemistry 46, 1393.Google Scholar
Maruyama, S, Nakagomi, K, Tomizuka, N & Suzuki, H (1985) Angiotensin-converting enzyme inhibitor derived and enzymatic hydrolysate of casein II. Isolation and bradykinin-potentiating activity on uterus and ileum the ileum of rat. Agriculture and Biological Chemistry 51, 1581.Google Scholar
Maubois, JL & Leonil, J (1989) Peptides du lait a activite biologique. Lait 69, 245.CrossRefGoogle Scholar
Meisel, H & Schlimme, E (1990) Milk proteins: precursors of bioactive peptides. Trends in Food Science and Technology 1, 4243.Google Scholar
Meisel, H & Schlimme, E (1994) Inhibitors of angiotensin I-converting enzyme derived from bovine casein (casokinins). In β-Casomorphins and Related Peptides: Recent Development [Branil, V and Teschemacher, H, editors]. Weinheim: VCH, Germany.Google Scholar
Migliore-Samour, D, Floch, F & Jolles, P (1989) Biologically active casein peptides implicated in immunomodulation. Journal of Dairy Research 56, 357.Google Scholar
Mullally, MM, Meisel, H & FitzGerald, RJ (1996) Synthetic peptides corresponding to α-lactalbumin and β-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biological Chemistry Hoppe-Seyler 377, 259260.Google Scholar
Naito, H, Kawakami, A & Imamura, T (1972) In vivo formation of phosphopeptide with calcium-binding property in the small intestinal tract of the rat fed on casein. Agriculture and Biological Chemistry 36, 409415.CrossRefGoogle Scholar
Nakamura, Y, Yamamoto, N, Kumi, S & Takano, T (1995) Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin-I converting enzyme. Journal of Dairy Science 78, 12531257.Google Scholar
Newburg, DS, Newbauer, SH & and, RGJensen (1995) Carbohydrates in milk. In Handbook of Milk Composition, pp. 273349 [Jensen, RG, editors]. San Diego: Academic Press.CrossRefGoogle Scholar
Newburg, DS, Pickering, LK, McCluer, RH & Cleary, TG (1990) Fucosylated oligosaccharides of human milk protect sucling mice from heat stable enterotoxin of Escherichia coli. Journal of Infectious Diseases 162, 10751080.Google Scholar
Newburg, DS & Street, JM (1997) Bioactive materials in human milk. Nutrition Today 32, 191201.Google Scholar
Pakkanen, R & Aalto, J (1997) Growth factors and antimicrobial factors of bovine colostrum. International Dairy Journal 7, 285297.Google Scholar
Pariza, MW (1997) Conjugated linoleic acid: a newly recognized nutrient. IFT Annual Meeting Orlando, FL, Abstract 15–3.Google Scholar
Parker, F, Migliore-Samour, D, Floch, F, Zerial, A, Werner, GH, Jolles, J, Casaretto, M, Zahn, H & Jolles, P (1984) Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis, and biological properties. European Journal of Biochemistry 145, 677.Google Scholar
Paroli, E (1988) Opioid peptides from food (the exorphins). World Review of Nutrition and Dietetics 55, 5897.Google Scholar
Payne, KD, Davidson, PM & Oliver, SP (1990) Influence of bovine lactoferrin on the growth of Listeria monocytogenes. Journal of Food Protection 53, 468472.Google Scholar
Petschow, BW & Talbott, BW (1991) Response of Bifidobacterium species to growth promoters in human and cow. Pediatric Research 29, 208213.Google Scholar
Regester, GO, McIntosh, GH, Lee, VWK & Smithers, GW (1996) Whey proteins as nutritional and functional food ingredients. Food Australia 48, 123126.Google Scholar
Reynolds, EC (1994) Anticariogenic casein-phosphopeptide. 24th International Dairy Congress, Melbourne, Australia, 1822 September.Google Scholar
Roberts, AK, Chierici, R, Sawatzki, G, Hill, MJ, Volpato, S & Vigi, V (1992) Supplementation of an adapted formula with bovine lactoferrin. I. Effect on the infant fecal flora. Acta Paediatrica 81, 119124.CrossRefGoogle Scholar
Saito, H, Miyakawa, H, Tamura, Y, Shimamura, S & Tomita, M (1991) Potent bacteriocidal activity of bovine lactoferrin hydrolysate repoduced by heat treatment at acidic pH. Journal of Dairy Science 74, 37243730.CrossRefGoogle Scholar
Sato, R, Noguchi, T & Naito, H (1986) Casein phosphopeptide enhances calcium absorption from the ligated segment of rat small intestine. Journal of Nutritional Sciences and Vitaminology 32, 6776.CrossRefGoogle ScholarPubMed
Schlimme, E & Meisel, H (1993) Bioactive peptides: structural physiological and analytical aspects. Newsletter of the IDF 139, (Suppl.), 5771.Google Scholar
Schmelz, EM & & Merrill, AH (1997) Milk sphingolipids: A new category of functional food. IFT Annual Meeting, Orlando, FL, Abstr 15–4.Google Scholar
Sekiya, S, Kobayashi, Y, Kita, E, Imamura, Y & Toyama, S (1992) Antihypertensive effects of tryptic hydrolysates of casein on normotensive and hypertensive volunteers. Journal of Japanese Society of Nutrition and Food Science 45, 513.CrossRefGoogle Scholar
Suzuki, T, Yamauchi, K, Kawase, K, Tomita, M, Kiyasawa, I & Okongi, S (1989) Collaborative bacteriostatic activity of bovine lactoferrin with lysozyme against E. coli 0111. Agriculture and Biological Chemistry 53, 17051706.Google Scholar
Svedberg, J, De Haas, J, Leimenstoll, G, Paul, F & Teschemacher, H (1985) Demonstration of β-casomorphin immunoreactive materials in in vivo digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans. Peptides 6, 625.CrossRefGoogle Scholar
Tani, F, Shiota, A, Chiba, H & Yoshikawa, M (1994) Saerorphin, an opioid peptide derived from bovine serum albumine. In β-Casomorphins and Related Peptides: Recent Developments, [Brandtl, V and Teschemacher, H, editors]. Weinheim: VCH, Germany.Google Scholar
Teschemacher, H (1987) Casein derived opioid peptides: physiological significance? Advances in Bioscience 65, 41.Google Scholar
Tirelli, A, De Noni, I & Resmini, P (1997) Bioactive peptides in milk products. Italian Journal of Food Science 9, 9198.Google Scholar
Tsuji, S, Hirata, Y, Mukai, F & Ohtagaki, S (1990) Comparison of lactoferrin content in colostrum between different cattle breeds. Journal of Dairy Science 73, 125128.Google Scholar
Van der Meer, R & Lapre, JA (1991) Calcium and colon cancer. Bulletin of the International Dairy Federation 255, 5559.Google Scholar
Viljoen, M (1995) Lactoferrin: a general review. Haematologica 80, 252267.Google Scholar
Walstra, P & Jenness, R (1984) Dairy Chemistry and Physics New York: John Wiley.Google Scholar
Wong, CW & Watson, DL (1995) Immunomodulatory effects of dietary whey proteins in mice. Journal of Dairy Research 62, 359368.Google Scholar
Yamamoto, N (1997) Antihypertensive peptides derived from food proteins. Biopolymers 43, 129134.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Yamauchi, K (1992) Biologically functional proteins of milk and peptides derived from milk proteins. Bulletin of the International Dairy Federation 272, 51.Google Scholar
Yen, SSC, Quingley, ME, Reid, RL, Ropert, JF & Cetei, NS (1985) Neuroendocrinology of opioid peptides and their role in the control of gonadotrophin and prolactin secretion. American Journal of Obstetrics and Gynaecololgy 152, 485.Google Scholar
Yolken, RH, Peterson, JA, Vonderfech, SL, Fouts, ET, Midthun, K & Newburg, DS (1992) Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis. Journal of Clinical Investigation 90, 19841991.Google Scholar
Yuan, YV & Kitts, DD (1991) Confirmation of calcium absorption and femoral utilisation in spontaneously hypertensive rats fed casein phosphopeptide diets. Nutrition Research 11, 12571272.Google Scholar