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Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers

Published online by Cambridge University Press:  08 March 2007

A. Gostner ,
V. Schäffer ,
S. Theis ,
T. Menzel ,
H. Lührs ,
R. Melcher ,
J. Schauber ,
T. Kudlich ,
G. Dusel  and
D. Dorbath
...Show all authors
A. Gostner*
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
V. Schäffer
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
S. Theis
Affiliation:
SUEDZUCKER AG, Wormser Strasse 11, D-67283 Obrigheim/Pfalz, Germany
T. Menzel
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
H. Lührs
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
R. Melcher
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
J. Schauber
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
T. Kudlich
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
G. Dusel
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
D. Dorbath
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
G. Kozianowski
Affiliation:
SUEDZUCKER AG, Wormser Strasse 11, D-67283 Obrigheim/Pfalz, Germany
W. Scheppach
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
*
*Corresponding author: Dr Andrea Gostner, fax +49 931 201 36 101, email [email protected]
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Abstract

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The polyol isomalt (Palatinit®) is a well established sugar replacer. The impact of regular isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined in a randomised, double-blind, cross-over trial with two 4-week test periods. Volunteers received 30 g isomalt or 30 g sucrose daily as part of a controlled diet. In addition to clinical standard diagnostics, biomarkers and parameters currently discussed as risk factors for CHD, diabetes or obesity were analysed. Urine and stool Ca and phosphate excretions were measured. In addition, mean transit time, defecation frequency, stool consistency and weight were determined. Consumption of test products was affirmed by the urinary excretion of mannitol. Blood lipids were comparable in both phases, especially in volunteers with hyperlipidaemia, apart from lower apo A-1 (P=0·03) for all subjects. Remnant-like particles, oxidised LDL, NEFA, fructosamine and leptin were comparable and not influenced by isomalt. Ca and phosphate homeostasis was not affected. Stool frequency was moderately increased in the isomalt phase (P=0·006) without changes in stool consistency and stool water. This suggests that isomalt is well tolerated and that consumption of isomalt does not impair metabolic function or induce hypercalciuria. In addition, the study data indicate that isomalt could be useful in improving bowel function.

Keywords

IsomaltMetabolic parametersStool parametersHealthy volunteers
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 4 , October 2005 , pp. 575 - 581
Copyright
Copyright © The Nutrition Society 2005

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