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The effects of gum arabic, wheat offal and various of its fractions on the metabolism of 14C-labelled aflatoxin B1 in the male weanling rat

Published online by Cambridge University Press:  09 March 2007

D. L. Frape ,
B. J. Wayman ,
Mary G. Tuck  and
E. Jones
D. L. Frape
Affiliation:
The Priory, Church Yard, Mildenhall, Suffolk IP28 7EE
B. J. Wayman
Affiliation:
Dalgety Spillers Ltd., Research and Technology Center, Station Road, Cambridge CB1 2JN
Mary G. Tuck
Affiliation:
Dalgety Spillers Ltd., Research and Technology Center, Station Road, Cambridge CB1 2JN
E. Jones
Affiliation:
Huntingdon Research Center, Huntingdon, Cambridgeshire PE18 6ES
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Abstract

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1. Male weanling rats were given for extended periods diets containing gum arabic or wheat offal or various offal fractions. The fractions included two lipid fractions, a water-soluble extract and a modified-acid-detergent (MAD)-fibre extract. The diets contained either low concentrations of aflatoxin B1 (induced rats) or were free from this source of aflatoxin (non-induced rats). The distribution of 14C was then studied after the rats received 14C-labelled aflatoxin B1 in their feed. Blood plasma concentrations of triglycerides, and total cholesterol were also measured.

2. Gum arabic and wheat offal accelerated the rate of passage of 14C through the small intestine and wheat offal very considerably decreased retention time in the large intestine. Both fibre sources increased faecal bulk. However, only wheat offal decreased liver and urinary accumulation of 14C and the effect could be explained entirely by the MAD-fibre fraction of wheat offal.

3. The possible induction of either microsomal enzymes unrelated to the production of mutagenic aflatoxin metabolites, or of extramicrosomal enzymes is discussed; but it is concluded that the main effect brought about by wheat offal on the toxicity and carcinogenicity of aflatoxin can be attributed to a direct influence of the MAD fibre fraction of wheat offal on the intestinal absorption of aflatoxin B1.

4. The relevance of these conclusions to drug safety studies is discussed, because comparable studies may yield differing results, despite a use of diets having the same nutrient composition but differing ingredient composition.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 48 , Issue 1 , July 1982 , pp. 97 - 110
Copyright
Copyright © The Nutrition Society 1982

References

REFERENCES

Ames, B. N., McCann, J. & Yamasake, E. (1975). Mutat. Res. 31, 347.CrossRefGoogle Scholar
Brown, R. C., Kelleher, J., Walker, B. E. & Losowsky, M. S. (1979). Br. J. Nutr. 41, 455.CrossRefGoogle Scholar
Brydon, W. G., Tadesse, K., Eastwood, M. A. & Lawson, M. E. (1980). Br. J. Nutr. 43, 101.CrossRefGoogle Scholar
Burkitt, D. P. & Trowell, H. C. (1975). Refined Carbohydrate Foods and Disease. London: Academic Press.Google Scholar
Chang, M. L. W. & Johnson, M. A. (1978). Fedn Proc. Fedn Am. Socs exp. Biol. 37, 542.Google Scholar
Chen, W.-J. L. & Anderson, J. W. (1979). Proc. Soc. exp. Biol. Med. 162, 310.CrossRefGoogle Scholar
Eastwood, M. & Mowbray, L. (1976). Am. J. clin. Nutr. 29, 1461.CrossRefGoogle Scholar
Fioramonti, J. & Bueno, L. (1980). Br. J. Nutr. 43, 155.CrossRefGoogle Scholar
Frape, D. L., Wayman, B. J. & Tuck, M. G. (1981). Br. J. Nutr. 46, 315.CrossRefGoogle Scholar
Frape, D. L., Wilkinson, J. & Chubb, L. G. (1970). Lab. Anim. 4, 67.CrossRefGoogle Scholar
Hayes, J. R., Mgbodile, M. U. K., Merrill, A. H. Jr., Nerurkar, L. S. & Campbell, T. C. (1978). J. Nutr. 108, 1788.CrossRefGoogle Scholar
Johnson, M. A. & Chang, M. L. W. (1978). Fedn Proc. Fedn Am. Socs Exp. Biol. 37, 542, Abstr. 1735.Google Scholar
Kay, R. M. & Truswell, A. S. (1975). Proc. Nutr. Soc. 34, 17A.Google Scholar
Kay, R. M. & Truswell, A. S. (1977). Br. J. Nutr. 37, 227.CrossRefGoogle Scholar
Keys, J. W. & De Barthe, J. V. (1974). J. Anim. Sci. 39, 57.CrossRefGoogle Scholar
Kritchevsky, D. & Story, J. A. (1974). J. Nutr. 104, 458.CrossRefGoogle Scholar
Kritchevsky, D., Tepper, S. A. & Story, J. A. (1975). J. Fd Sci. 40, 8.CrossRefGoogle Scholar
Lin, W. J. & Anderson, J. W. (1978). Fedn Proc. Fedn Am. Socs exp. Biol. 37, 542, Abstr. 1733.Google Scholar
Newberne, P. M. & Rogers, A. E. (1976). In Fundamentals in Cancer Prevention. p. 15 [Magee, P. N., Takayama, S., Sugimura, T. and Matashushima, T., editors]. Tokyo and Baltimore: University of Tokyo Press/University Park Press.Google Scholar
Oakenfull, D. G. & Fenwick, D. E. (1978). Br. J. Nutr. 40, 299.CrossRefGoogle Scholar
Oakenfull, D. G., Fenwick, D. E., Hood, R. L., Topping, L. R., Illmann, R. L. & Storer, G. B. (1979). Br. J. Nutr. 42, 209.CrossRefGoogle Scholar
Owen, D. E., Munday, K. A., Taylor, T. G. & Turner, M. R. (1975). Proc. Nutr. Soc. 35, 39A.Google Scholar
Patterson, D. S. P. (1973). Fd Cosmet. Toxicol. 11, 287.CrossRefGoogle Scholar
Ranhotra, G. S. (1973). Cereal Chem. 50, 358.Google Scholar
Ranhotra, G. S., Loewe, R. J. & Puyat, L. V. (1977). J. Fd Sci. 42, 1587.CrossRefGoogle Scholar
Ranhotra, G. S., Loewe, R. J. & Puyat, L. V. (1978). J. Fd Sci. 43, 1829.CrossRefGoogle Scholar
Riottot, M., Sacquet, E., Méjean, C. & Leprince, C. (1975). Nutr. Rep. int. 12, 1.Google Scholar
Southgate, D. A. T. (1976). In Fibre in Human Nutrition [Spiller, G. A. and Amen, R. J., editors]. London: Plenum.Google Scholar
Stasse-Wolthius, M. (1979). Qual. Plant. Plant Fd Hum. Nutr. 29, 1.Google Scholar
Story, J. A. & Kritchevsky, D. (1976). J. Nutr. 106, 1292.CrossRefGoogle Scholar
Suit, J. L., Rogers, A. E., Jetten, M. F. R. & Turiq, S. E. (1977). Mutat. Res. 46, 313.CrossRefGoogle Scholar
Truswell, A. S. (1975). Proc. Nutr. Soc. 34, 17A.Google Scholar
Truswell, A. S. & Kay, R. M. (1976). Lancet i, 367.CrossRefGoogle Scholar
Van Soest, P. J. (1963). J. Ass. off. agric. Chem. 46, 829.Google Scholar
Wattenberg, L. W. (1975). Cancer Res. 35, 3326.Google Scholar
Wicks, A. C. B., Yeates, J. & Heaton, K. W. (1978). Scand. J. Gastroent. 13, 289.CrossRefGoogle Scholar
Yacowitz, H., Fleischman, A. I. & Kritchevsky, D. (1976). 2nd Jt Mtg Am. Inst. Nutr., Am. Soc. Clin. Nutr., Nutr. Soc. Can. XXVI Abstr. 39.Google Scholar